atagablin will it be like gabapentin or pregablin?

[FPU4eva]

I see a vendor is planning on stocking this had some questions I see on the wikipedia page its a gabapentin analog and looking at the structure its closer to gabapentin then pregablin in looks

I do not know much about chemistry so I thought youd ask you folks if dosages are in pregablin range or gabapentin range?

thank you in advance. love ADD as i only understand 40% of what I read but very interested in drug design.

 

[Ceres]

I have no idea about dosage but wow that is an interesting molecule when compared to pregabalin.

 

[FPU4eva]

dont no if this is the same compound but it was under sources on a chem website

RESULTS

PD 0200390 was rapidly absorbed; mean time to maximum plasma concentration was 1.66–3.24 h. Mean half-life in subjects with normal renal function was 5.36 h, and increased with worsening RI. Oral (CL/F) and renal (CLR) clearance rates decreased with deteriorating renal function, whereas area under the concentration–time curve (AUC0–∞) values increased by 56, 117 and 436% in subjects with mild, moderate and severe RI, respectively, indicating increased PD 0200390 exposure. Regression analysis demonstrated that CL/F and CLR correlated with CLcr (r= 0.953 and 0.961, respectively). PD 0200390 was well tolerated in subjects with mild, moderate or no RI. The most common adverse events were somnolence, dizziness and headache; these occurred with greatest intensity in the severe RI group.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767279/?tool=pmcentrez


somnolence, dizziness=euphoria? i know from experience with pregablin that high doses have caused the most euphoria from any compound I have ever consumed

found some dosage information
Single- and multiple-dose studies of the safety and pharmacokinetics of PD 0200390 in a total of 84 healthy human subjects indicated that PD 0200390 is safe and well tolerated at single doses up to 150 mg and multiple doses up to 100 mg twice daily and 150 mg once daily for 14 days [8, 9]. A dose-proportional pharmacokinetic profile with low intersubject variability was observed in these subjects. The half-life of 5–6 h and time to reach maximum plasma concentration (Cmax) of 1.3 h, associated with 50% of maximal pharmacodynamic response (EC50) occurring at plasma concentrations of 1.1–1.6 µg ml−1 for pharmacodynamic measures of sleepiness (visual analogue scale for sleepiness and Stanford Sleepiness Scale), were consistent with potential efficacy in sleep onset and maintenance, and minimal risk of next-day effects with appropriate dosing [8].

so 150mg is the max dose they could say was well tollerated. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767279/?tool=pmcentrez

 

[syntheticbreakfast]

so 150mg is the max dose they could say was well tollerated. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767279/?tool=pmcentrez

If it's similar to gabapentin and pregabalin, I'm sure you can take it a lot higher. Most people seem to recommend 600-1200 mg of PGN for recreational use, but you can push it to 2100+ mg easily without problems arising. Still, with a brand new compound everyone should start really low (obviously). I wonder how it compares to the other gabapentinoids...

I hope it's better than pregabalin.

 

[Mercc96]

I'd be worried about getting dependant on anything like this if it causes euphoria.

 

[FPU4eva]

I'd be worried about getting dependant on anything like this if it causes euphoria.

id also want to warn of this pregablin withdrawl was the worst experience of my life coming from a 1.2gram a day habit, had seizures and went into a catonic state because I dident taper correctly. I have a feeling from reading the bit of articles on the compound unless they lie about its abuse potential like lyrica it will not be marketed.