At what dose of test does estradiol usually become a problem

paranoid android

paranoid android

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I am currently on 200mg of test a week and my last blood work was good. I was thinking about maybe increasing to 250 a week in a month or so. At what dose of test does estrogen usually become a problem?
 
Its all dependent on your genetics, body fat percentage and frequency of administration.

Higher levels of body fat = more active aromataze enzyme causing more conversion from testosterone into estradiol.

Higher frequency injection is also better for more stable blood levels causing less spikes in free testosterone floating around that aromatizes into estradiol.

And finally genetics will vary from guy to guy, some men can handle up to 500mg testosterone without using an AI while another guy might get issues at just 150mg. Of course most guys will be somewhere in between, only way to know really is to go and get your bloodwork done. Generally most guys will get issues with estradiol above 250mg/week and have to use some form of AI or other means to lower their estrogen
 
TheLightBringer said:
Its all dependent on your genetics, body fat percentage and frequency of administration.

Higher levels of body fat = more active aromataze enzyme causing more conversion from testosterone into estradiol.

Higher frequency injection is also better for more stable blood levels causing less spikes in free testosterone floating around that aromatizes into estradiol.

And finally genetics will vary from guy to guy, some men can handle up to 500mg testosterone without using an AI while another guy might get issues at just 150mg. Of course most guys will be somewhere in between, only way to know really is to go and get your bloodwork done. Generally most guys will get issues with estradiol above 250mg/week and have to use some form of AI or other means to lower their estrogen
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Ya im at 200mg njected once weekely. Gonna go to 250mg's a week if my next blood work comes out ok
 
Depends a lot on your body fat your muscle mass and the diet.
When I was very lean and muscular I cloud handle 500mg no problem and 750mg with very low dose AI once every few weeks.
Now for the last 2 years I haven’t trained and my BF has increased so if I’m reckless with the diet and the beers I aromatise at even 150mg
 
Something changed with me about a decade ago when I dieted down to single digit body fat.

Previously anything 500mg+/week of test, regardless of ester, I needed AI/SERM to alleviate estrogen side effects such as nipple sensitivity, loss of libido, mood swings, etc. Arimidex 0.5 x2 weekly was sufficient back then.

Dieted down to probably around 8% and have not since had estrogen issues with test doses of 1g/week and other aromatizing agents on top such as dbol, treat, etc. No idea wtf happened. Since then I have gotten equally or even more so lean and when androgenic compounds like winstrol were used on top of decent testosterone (600-800/week) doses I'd have off and on low estrogen symptoms such as joint pain, inability to maintain erections, and dulled affect/mild anhedonia. I'd have to lower the winstrol or bump test higher to alleviate symptoms.
 
Serotonin101 said:
Something changed with me about a decade ago when I dieted down to single digit body fat.

Previously anything 500mg+/week of test, regardless of ester, I needed AI/SERM to alleviate estrogen side effects such as nipple sensitivity, loss of libido, mood swings, etc. Arimidex 0.5 x2 weekly was sufficient back then.

Dieted down to probably around 8% and have not since had estrogen issues with test doses of 1g/week and other aromatizing agents on top such as dbol, treat, etc. No idea wtf happened. Since then I have gotten equally or even more so lean and when androgenic compounds like winstrol were used on top of decent testosterone (600-800/week) doses I'd have off and on low estrogen symptoms such as joint pain, inability to maintain erections, and dulled affect/mild anhedonia. I'd have to lower the winstrol or bump test higher to alleviate symptoms.
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I've a somewhat similar, although less extreme experience.

Recently I had some digestive tract issue for over 2 months, probably a gut biome unbalance.
Almost everything would cause me to get the shits.
So I eliminated food and drinks of all types until I basically was down to meat, fish, eggs, and only goat and sheep milk and dairy products.
I lost about 8kg, but 4 were water and glycogen as I put them back on relatively quickly after my intestine resumed working normally.

I was already at about 12% bodyfat before that, and it looks I mostly lost ventral fat as my midsection became much smaller.
Well I've had to reduce my EQ since then, and also increase my test as I was getting typical low E2 symptoms.

Maybe ventral fat has more aromatase enzyme than subcutaneous fat?
 
Phobos said:
I've a somewhat similar, although less extreme experience.

Recently I had some digestive tract issue for over 2 months, probably a gut biome unbalance.
Almost everything would cause me to get the shits.
So I eliminated food and drinks of all types until I basically was down to meat, fish, eggs, and only goat and sheep milk and dairy products.
I lost about 8kg, but 4 were water and glycogen as I put them back on relatively quickly after my intestine resumed working normally.

I was already at about 12% bodyfat before that, and it looks I mostly lost ventral fat as my midsection became much smaller.
Well I've had to reduce my EQ since then, and also increase my test as I was getting typical low E2 symptoms.

Maybe ventral fat has more aromatase enzyme than subcutaneous fat?
Click to expand...
That gut issue sounds like hell, ive had some pretty chronic gut issues myself and also went through a period of essentially eliminating most foods.

Have you tried BPC-157 for gut health? Ive seen many great anecdotes about its efficacy. Im currently taking SubQ BPC-157 for some injuries but ill report if it helps my gut at all.
 
TheLightBringer said:
That gut issue sounds like hell, ive had some pretty chronic gut issues myself and also went through a period of essentially eliminating most foods.

Have you tried BPC-157 for gut health? Ive seen many great anecdotes about its efficacy. Im currently taking SubQ BPC-157 for some injuries but ill report if it helps my gut at all.
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I have not used BPC for gut health, but my brother did and it really worked for him, he had what he thought were leaky gut symptoms and the BPC157 TB 500 stack got him to feel much better quickly.

In terms of injury recovery BPC 157 + TB500 worked much better for me when stacked with CJC1295, a GH releasing peptide.
I was also on 200mg Test Cyp and about 40mg Boldenone Undecylenate.
I had pulled a muscle in my back really badly, and it caused serious pain for a while.

If you have trouble with your gut look into butyrate supplementation, it is a SCF (short chain fatty acid) that is present in small amounts in some foods like dairy and is mostly produced by gut bacteria, apparently it can be VERY beneficial and in one study even reversed atherosclerotic plaque in mice.
 
Phobos said:
I have not used BPC for gut health, but my brother did and it really worked for him, he had what he thought were leaky gut symptoms and the BPC157 TB 500 stack got him to feel much better quickly.

In terms of injury recovery BPC 157 + TB500 worked much better for me when stacked with CJC1295, a GH releasing peptide.
I was also on 200mg Test Cyp and about 40mg Boldenone Undecylenate.
I had pulled a muscle in my back really badly, and it caused serious pain for a while.
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Currently taking BPC-157, TB-500, GHK-CU and KPV, so the ”KLOW” stack basically but from separate vials as GHK-CU can act as an oxidizing agent and degrade other peptides if in the same vial
Phobos said:
If you have trouble with your gut look into butyrate supplementation, it is a SCF (short chain fatty acid) that is present in small amounts in some foods like dairy and is mostly produced by gut bacteria, apparently it can be VERY beneficial and in one study even reversed atherosclerotic plaque in mice.
Click to expand...
Ive heard about butyrate and seen good anecdotes about it, been procastinating ordering it but Ill probably go for it after this reminder. Although my gut issues stem mostly from idiopathic Bile Acid Malabsorption and some form of IBS, I have a hunch that it could somehow be connected to my hypermobile Ehlers Danlos Syndrome.
 
TheLightBringer said:
Higher levels of body fat = more active aromataze enzyme causing more conversion from testosterone into estradiol.
Click to expand...
There's other factors at play which induce aromatase:
The activity of aromatase increases with aging, and under the influence of prolactin, cortisol, prostaglandin, and the pituitary hormones, FSH (follicle stimulating hormone)
...
It is inhibited by progesterone, thyroid, aspirin, and high altitude. Aromatase can produce estrogen in fat cells, fibroblasts, smooth muscle cells, breast and uterine tissue, pancreas, liver, brain, bone, skin, etc.
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Looks like melatonin induces aromatase too:
- https://doi.org/10.1038/s12276-020-00491-w
 
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Allylbenzene said:
There's other factors at play which induce aromatase:


Looks like melatonin induces aromatase too:
- https://doi.org/10.1038/s12276-020-00491-w
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In human granulosa lutein cells, which males dont have… this is also a study done on people with ovarian hyperstimulation syndrome and conducted on mice.


We even have pubmed studies claiming that melatonin inhibits aromataze activity, though lots of anecdotes show that to be essentially irrelevant with people on bodybuilding and PED forums trying out high doses of melatonin and seeing no significant change on their bloodwork.
 
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