Aspergers Syndrome Treatment

[88brenno]

With the expanded and extended use of stimulants comes mounting concern that the drugs might take a toll on the brain over the long run. Indeed, a smattering of recent studies, most of them involving animals, hint that stimulants could alter the structure and function of the brain in ways that may depress mood, boost anxiety and, contrary to their short-term effects, lead to cognitive deficits. Human studies already indicate the medications can adversely affect areas of the brain that govern growth in children, and some researchers worry that additional harms have yet to be unearthed.


Medicine for the Mind
To appreciate why stimulants could have negative effects over time, it helps to first understand what they do in the brain. One hallmark of ADHD is an underactive frontal cortex, a brain region that lies just behind the forehead and controls such “executive” functions as decision making, predicting future events, and suppressing emotions and urges. This area may, in some cases, be smaller than average in ADHD patients, compromising their executive abilities. Frontal cortex function depends greatly on a signaling chemical, or neurotransmitter, called dopamine, which is released in this structure by neurons that originate in deeper brain structures. Less dopamine in the prefrontal cortex is linked, for example, with cognitive difficulty in old age. Another set of dopamine-releasing neurons extends to the nucleus accumbens, a critical mediator of motivation, pleasure and reward whose function may also be impaired in ADHD.
Stimulants enhance communication in these dopamine-controlled brain circuits by binding to so-called dopamine transporters—the proteins on nerve endings that suck up excess dopamine—thereby deactivating them. As a result, dopamine accumulates outside the neurons, and the additional neurotransmitter is thought to improve the operation of neuronal circuits critical for motivation and impulse control.

READ MORE @ http://amphetamines.com/adhd/drugsbrain.html

^I'd say the same, but this kid is still naive - "WOW SCHEDULE 8 DRUG SCRIPT - NOW I CAN DO ALL MY WORK, NEVER SLEEP AND PARTY LIKE A CHAMPION".

Or at least that how it works for all my friends in the same place as this guy... then they grow up. Pity fried brains just don't work that well anymore.

Dr. Gulley hypothesizes that amphetamine abuse in adolescence disrupts normal brain development. This experiment has very important implications. One form of teenage drug abuse is Adderall abuse as well as abuse of other stimulants. Teens will take amphetamines (stimulants) such as Adderall for Attention Deficit Disorder which is safe at the doses prescribed.

http://teenagealcoholism.net/teenage-drug-abuse-brain-damage-from-amphetamine-abuse/

 

[mystery mister E]

For what it's worth, I have previously been clinically diagnosed with Aspergers. My personal experience was that once I did MDMA at Uni (about 1992) it turned the 'feeling' part of my brain that hitherto hadn't been connected. I have been a changed person since then.

MDMA is a wonderfully unique drug, pity it was banned on a knee jerk reaction instead of having it's clinical properties fully explored.

Peace.

 

[88brenno]

MDMA ftw

 

[88brenno]

sorry for the double post but wanted to bump it,

So I had an argument with my boss cause he was being a cunt, and i wrote a text to my mate telling him what happened was meant to send it to my mate, but after writing the text my mind was going a million miles a second, and I sent it to my boss for some reason, then he confronted me and I told him wasnt meant to send to him and then 5 mins later i sent another mate a text saying the same thing and my mind was thinking how much of a cunt my boss was that i somehow sent it to my boss AGAIN....after a heated argument I stormed out, never to return again. I deffinately think I could benifit from dexies? thoughts?

 

[djep]

Hey brenno,

Some time ago I recall getting an email from MAPS regarding them having some anecdotal reports of recreational use of MDMA assisting those with Aspergers and asking anyone that has benefited from such use to contact them with details. Unfortunately I have deleted that email but their recent newsletter on their website does have a short paragraph regarding MDMA assisted therapy - http://www.maps.org/media/update/maps_news_2_10_12/#6

Maybe write to them and see if they can enlighten you with any further info.

 

[Mr Blonde]

sorry for the double post but wanted to bump it,

So I had an argument with my boss cause he was being a cunt, and i wrote a text to my mate telling him what happened was meant to send it to my mate, but after writing the text my mind was going a million miles a second, and I sent it to my boss for some reason, then he confronted me and I told him wasnt meant to send to him and then 5 mins later i sent another mate a text saying the same thing and my mind was thinking how much of a cunt my boss was that i somehow sent it to my boss AGAIN....after a heated argument I stormed out, never to return again. I deffinately think I could benifit from dexies? thoughts?

That's an unfortunate situation.

From reading this thread, it seems as though you are putting a lot of hope on the dexamphetamine as the best treatment for you. It will probably help, but you need to remember that it is not a cure-all, has side effects and is addictive. Seeing as you have had trouble keeping to your benzodiazepine prescribed dose, you need to be very careful with the dexamphetamine script. Also, it alone will not do all the work for you; you will have to put some effort in yourself to make long-term changes to your behavior.

 

[MrIbis]

Brenno, i think you're just placing too much hope in DRUGS, truth is - the drugs won't fix the problem, only make it bearable. Eventually, they won't work any more - and you'll have burnt yourself so far thin that theres no helping the problem with any type of therapy or medication. The best thing to do here mate is for you to let a doctor/specialist decide, trial and error and use your spare time to help you find things that ease the anxiety without the need for drugs.

It's worth giving it all a try. Looking through your posts I can tell that you're quite young. Good luck.

 

[88brenno]

My mum is going to buy me a book she said helped her immensley with anxiety, (she doesnt take any meds for it) so I will try reading that, but it still doesn't fix the innatentive problems I have. I will try the dexies anyway, If it is causing me to quit my job all the time I think that is reason enough to try medication. I realise its not a cure all and I need to put in the effort aswell, which I do (try) anyway.

Thanks for the posts M_B and Ibis

edit: As I understand it, the doc puts you on a month trial and re-evaluates the situation, If it is helping alot, with tolerable side effects in my mind that makes it worth it. ???

 

[puckboy]

Have you considered that you keep quiting your jobs because they're unsatisfying and not what you want to do? Why would you want to medicate yourself just so you can blend into some bullshit job and be numb to the fact you actually don't want to be doing that.

Those feelings you have are important if you ask me. It's your brain telling you it isn't happy and wants to live differently - it doesn't mean you have a condition and need medication. You're alive - you're experiencing life. It's not all great and the times it sucks are important for you to know where you want to be heading and what you want out of life.

This is just my opinion but I think far too many people go on SSRIs, benzos, dexies etc when they don't need to. People want to pop a pill for any negative feeling they encounter - I say listen to those feelings and understand what they're telling you - then work towards changing them.

I used to be very much like you by the way and was on dexies/benzos for a while and it ended really really badly with addictive behaviour and shocking withdrawal.

Good luck man.

 

[88brenno]

My last job I actually enjoyed alot, was mainly computer work, which is my favourite thing to do. Also I got to go do pickups a couple times a week which sometimes meant driving for a couple of hours being paid, getting out of the office is always good, but my innattentive qualities made it hard for me to finish on time, sometimes getting lost while driving and taking longer than I should to get back, and holding conversations with trusted people (people I had no anxieties with) not many.. was hard because of my distractions/drifting mind if you know what I mean.

My dad even commented more than a couple of times on how I was coming home in a better mood since i got the new job and hes not really one to pick up on one of those type of things.

I do value your input and the time spent in trying to help me, but judging by those factors listed above, I believe since I was actually enjoying the job but it was just hard for me, I could benefit from the dexies, also dont forget the text message sent twice to my boss in 5 minutes (was meant to send to mates) calling him a cunt (which is the reason for me walking out and not returning) I would think that alone points to ADD.

 

[Mr Blonde]

^ As long as you understand that the drugs may not work forever, in which case you need to have other strategies in place. Keep us updated on how treatment goes, and hopefully you do see improvements that you can build upon.

 

[88brenno]

That is something the prescribing doc and I will work towards I guess, and I will deffinately keep you in the loop. Thanks for all the replies I will try my best to stick to therapeutic doses.

 

[Charles Bronson]

Maybe your right, it just gets to me alot, when my boss thinks im usless for forgetting/being distracted all the time, you can understand that right. Also the dose of benzos I need to control my anxiety is higher than what my doc will prescribe and I am terrified of a seizure or something, thats not to say I dont abuse them every now and then. I have a hard enough time controlling my benzo use, let alone a dex script..... Maybe my brail will thank me more if I just keep self medicating with weed... At the moment I cant even get the good ol' greens though and SSRI/SNRI doesnt really make me feel any better, although I have only tried about 4.

On that note, FMI how much worse is dexie use (abuse) than LSD/weed/opiates limited to Tramadol/Codeine

Dexamphetamine has fucked up my short and long term memory, now that I'm not on it, and from years of abuse (search for my previous posts). Benzodiazepines actually help me articulate the way in which I want to write an assignment nowadays, it's fucking weird I know.

IMO, FYI, Dexamphetamine use is not that potentially damaging, in terms of long-term health consequences. Opiates are by far the worst, coming in second to LSD, than Dexamphetamine and weed.

 

[88brenno]

Does anyone know what the ng/ml cutoff concentrations for THC are? I am going to buy a test on ebay that says 50ng/ml for THC is what they use in labs? Does that sound about right?

 

[ThHardMotherfucker]

Does anyone know what the ng/ml cutoff concentrations for THC are? I am going to buy a test on ebay that says 50ng/ml for THC is what they use in labs? Does that sound about right?

To the guy mocking Aspergers, how about you find something better to do with your time...

Why don't you smoke marijuana? A better hit of THC.

 

[tomorrow]

My mum is going to buy me a book she said helped her immensley with anxiety

What is the name of the book?
Also, how are you getting on 88brenno?

 

[Flynnal]

I suspect I have ASD, but also some ADHD. I tried dex and frankly whilst it helped with motivation and mood it hindered sleep at night. Perhaps if I'd combined it with clonazepam for anxiety I would have had a much better time but my psychiatrist wasn't comfortable prescribing two highly dependence forming drugs, which they both are.

I guess I'll have to reevaluate this and look into it again, but I also suspect I have brain damage, because I did suffer from hypoxia due to an extra long labour and birthing process which was traumatic. I suspect this caused a lot of my problems, not to mention some emotional (and occasionally physical abuse - I would get hit with a leather belt if I did something wrong even though I didn't understand that it was wrong) as a child. I also got molested twice in the space of 2 weeks by someone I did not recognise the first time, lured with lollies and then the second time there were threats against my manhood. Then losing my mother at only 12. All this took a toll and I've not truly recovered from it all. This isn't trauma dumping by any stretch, it's just the facts presented in a coherent manner.

I won't allow it to screw up my life, but I know it has had some influence. I don't even know if the drugs would work. I use cannabis oil, suvorexant for sleep, occasional caffeine and clonazepam, and some low dose nicotine these days, but I'm careful with the nic because that too is highly dependence forming.

 

[Electrum1]

Dysbiotic microbiota in autistic children and their mothers: persistence of fungal and bacterial wall-deficient L-form variants in blood - PubMed

Based on our hypothesis for existing microbiota of wall-deficient variants (L-forms) in human blood, we created an innovative methodology, which allowed for the development of L-form populations from blood of all investigated people. In contrast to healthy controls, blood L-forms from autistic...

pubmed.ncbi.nlm.nih.gov

Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox

A child with symptoms placing him within the autism spectrum and with urine biochemical markers consistent with fungal (Aspergillus) colonization of the gastrointestinal tract was first treated with the antifungal probiotic Saccharomyces boulardii. A ...

www.ncbi.nlm.nih.gov

 

[snmfmy]

Dysbiotic microbiota in autistic children and their mothers: persistence of fungal and bacterial wall-deficient L-form variants in blood - PubMed

Based on our hypothesis for existing microbiota of wall-deficient variants (L-forms) in human blood, we created an innovative methodology, which allowed for the development of L-form populations from blood of all investigated people. In contrast to healthy controls, blood L-forms from autistic...

pubmed.ncbi.nlm.nih.gov

Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox

A child with symptoms placing him within the autism spectrum and with urine biochemical markers consistent with fungal (Aspergillus) colonization of the gastrointestinal tract was first treated with the antifungal probiotic Saccharomyces boulardii. A ...

www.ncbi.nlm.nih.gov

Yeah no.

Autism and autism spectrum disorders have been categorically proven to be caused by hyper-connectivity in the brain. It happens in utero, and it's not caused by any exogenous toxin it's epigenetic.

Brain hyper-connectivity in children with autism and its links to social deficits

Autism spectrum disorder (ASD), a neurodevelopmental disorder affecting nearly 1 in 88 children, is thought to result from aberrant brain connectivity. Remarkably, there have been no systematic attempts to characterize whole-brain connectivity in children ...

www.ncbi.nlm.nih.gov

I have Asperger's because I'm old enough to have Asperger's and not ASD lol.

mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity​

mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity - Nature Communications

Autism spectrum disorder (ASD) is characterised by synaptic surplus and atypical functional connectivity. Here, the authors show that synaptic pathology in Tsc2 haploinsufficient mice is associated with autism-like behavior and cortico-striatal hyperconnectivity, and that analogous functional...

www.nature.com

 

[snmfmy]

That functional hyperconnectivity expresses itself in many different ways depending on the degree.

I can smell things better than almost any human I know. I can distinguish between individual people when they walk in the room from their body odor and I'm not talking about sweaty stinky people.

But I also am very sensitive to certain scratchy fabrics, I have hyperacusis (hyper hearing & hyper response to nominal sounds) where for years until I trained myself out of it the smallest sound would wake me up. If the refrigerator four rooms away compressor cut on it would wake me up.

I also finished high school and some college by the age of 16. And it was boring. I scored over 700 on math and verbal on my SATs when I was 15 years old. And it was boring. If I'm not learning new facts, or a new language, or a new way to do something or something completely new, I'm like a German Shepherd without work. I lose my mind.

Functional cortical hyper connectivity also results in such information overload that the autistic brain is unable to comprehend it. And causes social deficit seen in autism spectrum disorder.

I absolutely have mind blindness like Sasha Baron Cohen talks about in his seminal works on autism. It caused major issues in my relationships because in my mind everybody liked the same things that I did. So why would they watch a TV show that I thought was stupid.

As far as MDMA and it's effects on the ASD psyche. I found that it allows you to override programming very quickly that otherwise would take a very long time to reprogram.

I literally reprogrammed my brain to not freak out like Dustin Hoffman in rain Man when things that bothered me happened. And I lost a marriage over it.

There is a huge level of inertia associated with existing memes/ neural paths in people with ASD relative to the regular population.

To give you an example, for years I suffered from what most people will call obsessive compulsive disorder but it was simply ASD list checking assurance. Did I pay the mortgage? Did I pay the water? Did I pay the electric? Did I remember to go shopping for food last night that I locked the door? Did I turn off the lights? Did I turn off the dryer? Did I did I did I did. I. Did I? It was a litany that I went through every day over and over and over throughout the day consciously in subconsciously.

Through the use of MDMA and actual verbally reprogramming through psycho cybernetics, the stimulus action response table in my brain for several overreactions that were in grained in me. I managed to do in a few weeks what had taken me several years for some of the other issues I had.

To sum it up, my youngest daughter one time came up to me and gave me a hug. I think she was about seven or eight and she said

"DAD EVEN THOUGH YOU'RE A ROBOT IN A HUMAN'S BODY WE STILL LOVE YOU"

And that that instigated me reprogramming my own thought processes as if I was writing code at my day job which I did.