SynAmnesia
Bluelighter
- Joined
- Nov 25, 2007
- Messages
- 108
MattPsy said:SynAmnesia:
I can find no evidence toward your statement that insulin induces the release of serotonin either.
Insulin causes most of the small neutral amino acids to leave the blood stream and be absorbed into other tissues. This statement is also true for glucose, which is why insulin causes glucose to leave the bloodstream. However, tryptophan is a large non-polar molecule that remains bonded to the albumin in the bloodstream, and therefore a higher concentration of tryptophan stays in the blood relative to the other neutral amino acids. This causes more tryptophan to be transported across the blood brain barrier via the neutral amino acid transport protein. The increase in tryptophan gets converted into seritonin as tryptophan is the limiting reagant in the synthesis of seritonin. Some of this seritonin is stored in vesicles to be released on signalling, however, quite a bit of this is released upon creation directly into the synapse. Therefore, insulin causes increased seritonin production, which causes increased seritonin release. In fact, this is one of the reasons you get sleepy after thanksgiving. It isn't the turkey (which has no more tryptophan than any other type of protein)--it is all the other carbs, which bump up your tryptophan levels.
I can find a source for this, but not now. I need to do my other work. If you want a source for this, I will get back to you in a few days.
