Artificially acquired natural high

[Tsukasa]

So i've been taking diphenhydramine for a while, an anti-histamine and anti-cholinergic, and found that on cessation I have high levels of both histamine and acetylcholine. I have a stuffy nose, sneeze more frequently, and have other allergy-like symptoms caused by histamine. The high levels of acetylcholine give me a greatly reduced appetite and desire to smoke (despite also quiting a small smoking habit), as well as increased perspiration and salivation. I did not really expect this.

So this got me wondering, what if I took other antagonistic drugs: anti-psychotics like chlorpromazine and opiate blockers like naltrexone or naloxone for a period of time at night, and then abruptly stopped. This would result in elevated levels of those neurotransmitters which it blocked, like dopamine, serotonin, opioids, acetylcholine, and others, resulting in a natural chemical high.

Discuss.

 

[SKL]

I don't think it works like that, and, besides, I guarantee you how shitty you'd feel in the interim wouldn't be worth what it'd feel like in the end.

 

[Tsukasa]

^ It worked like that for me. I took the diphen. nightly as a sleep aid, so the sedative effects were actually pleasurable and served me. If I didn't take it one night, the withdrawal symptoms would start in the morning. Same thing happened when i used to take alpha blockers in the evening for my CPPS. When I stopped I seemed to be more prone to the adrenaline rush and felt more anxiety in situations I normally wouldn't.

 

[The Monkey Mantra]

I dunno. There are some people who take low doses of naltrexone at night and get a painkilling effect in the morning, but there are also people who take ULTRA low doses and get a painkilling effect right away. No one's really sure what the mechanism is.

I remember taking Gabitril (a GABA reuptake inhibitor) for a couple weeks at a low dose. When I went off of it, boy, I felt so darn *zesty*.

 

[nuke]

Get down to get high? Xyrem (GHB) is supposed to be effective in narcolepsy because of this reason.

I never experienced any kind of dopaminergic rebound from my few usages of antipsychotic compounds (nor any wakefulness promoting effects the day after taking diphenhydramine for sleep). However, it can make me nauseous in the morning and worsen my tremors.

 

[SKL]

Get down to get high? Xyrem (GHB) is supposed to be effective in narcolepsy because of this reason.

On an at best tangentially related note, isn't zolpidem used to snap people out of comas?

 

[lenses]

Diphendramine is a SSRI!

You know that it was the basic for prozac and other ssris?

 

[Tsukasa]

^ Yea, thats another reason i started taking it. I liked the mood-brightening effect it gave too. Though for this experiment I would take the chlorpromazine which is also an anti-cholinergic/histamine, and not diphen.

 

[yasu]

if you start taking the chlorpromazine its ganna give you some tardive dyskinesia as well as depression while you're getting yourself tolerant.

For the natrexone/naloxone, an antagonists will NOT work without an agonist present. ie unless you're producing heaps and heaps of endogenous opioids, the antagonist are going to have little effect and the time it takes to get tolerant aint worth the short time high you'll get. Also note that naloxone is NOT orally bioavaliable.

Bottom line is, use direct/indirect agonists of your chosen receptor. Morphine, amphetamine, MDMA etc