N&PD Moderators: Skorpio
Article request: SAR of mecamylamine analogs
"Synthesis of 2-exo- and 2-endo-mecamylamine analogs. Structure-activity relationships for nicotinic antagonism in the central nervous system" J. Med. Chem., 1991, 34 (3), pp 1003–1010
Of interest to nobody but myself, possibly. Any help appreciated.
I found this abstract...won't let me see the whole thing because they want a subscription...
http://jpet.aspetjournals.org/content/254/1/45.abstract
I posted the above link because it is an pharmaceutical evaluation and in the one you had posted it said there had been no studies with a ?(its in your post in the second paragraph after the abstract..It is the last 3-4 sentences)..............
Hi Kayla. Yeah, same authors and they probably wrote both articles at around the same time. I'm interested in the SAR data on the analogs because even though mecamylamine has been around for over half a century, the S-2-endo isomer is likely to be promoted as an antidepressant in the next few years. My library account at the University of the 3rd World doesn't give me electronic access to the article.
MurphyClox
Bluelighter
John A. Suchocki, Everette L. May, Thomas J. Martin, Clifford George, Billy R. Martin
"Synthesis of 2-exo- and 2-endo-mecamylamine analogs. Structure-activity relationships for nicotinic antagonism in the central nervous system."
J Med Chem 1991, 34(3), pp.1003–1010
DOI: 10.1021/jm00107a019
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Technically, I posted an article dealing with synthesis. If this offends the local rules please immediately delete my post.
Cheers! - Murphy