Appreciation of Music and Medications!!

[blight12]

Besides MDMA as the king of music appreciation, phenibut was very surprisingly epic at this task as well, which im glad to see is confirmed by mention of other GABA drugs here.

 

[MMMMKAY?!]

I have been off the beta blockers for a while and find a dramatic (positive) difference in listening to music, and am alot less 'down' all the time. Only problem is I've been more irritable, impulsive and anxious.
Since atenolol doesn't pass the blood brain barrier would it have the same negative effects on music?
And they are also thinking about putting me on tenex (guanfacine) does anyone have any expierence of taking tenex and listening to music??
:]]

 

[pasha]

I'm glad you've solved your problem with music. I guess my primary suspicion that the beta-blocker was causing it was correct. As bronson said before though, are you sure you're willing to sacrifice personal well being at the expense of music appreciation?

Atenolol is a selective beta-blocker meaning it shuts down specific adrenergic receptors unlike propranolol, which means some receptors will stay open. Since the complete blockade of adrenaline is the culprit in the depression and ahedonia that come with propranolol, It would make sense that it would be noticeably better with atenolol. However I would expect it to carry the same side effect but a lesser degree. Atenolol does cross the blood-brain-barrier, just not to the same degree that propranolol does.

Guanfacine is the brother of clonidine, which decrease cardiac output by stimulating adrenergic receptors. These medications are also anti-hypertensives, they carry a similar risk of depression. They're used off-label for sleep disorders, anxiety, and psychotic symptoms in schizophrenia at times but they have some serious side effects. These drugs are very potent and can dramatically reduce blood pressure, and can cause dependence with withdrawal manifesting in extreme rebound hypertension if not tapered correctly. It's also contraindicated to mix guanfacine with beta-blockers.

What is your medication looking like now since you've altered it?

 

[MMMMKAY?!]

They are: 30mg addy xr morning, 10mg addy xr noon. 400mg Gabapentin TID. 50mg trazadone at bedtime and 50mg diphenhydramine at bedtime.
I feel kinda manic ://
I get out of here on the 25th though (so ill be able to see my own doctor) and am hoping to get on something like: 20mg Dexedrine IR Morning and noon. Wellbutrin XL morning. Buspar 10mg TID. and off all the rest though I dont know if ill be able to get off the gabapentin since im on it technically for nueropathic pain.

 

[Pagey]

Hadn't seen this thread until now, but I'm happy to hear things have gotten better OP. I've never been on SSRIs but when I got to be on high doses of benzos they made it impossible for me to enjoy music, and it was horrible. I think it's a good plan in any case to try to get off some of those drugs. Sorry I can't be of more help, just wanted to show my support

 

[MMMMKAY?!]

Thanks for your opinion :]]
thats good to know about benzos too.

 

[pasha]

They are: 30mg addy xr morning, 10mg addy xr noon. 400mg Gabapentin TID. 50mg trazadone at bedtime and 50mg diphenhydramine at bedtime.
I feel kinda manic ://
I get out of here on the 25th though (so ill be able to see my own doctor) and am hoping to get on something like: 20mg Dexedrine IR Morning and noon. Wellbutrin XL morning. Buspar 10mg TID. and off all the rest though I dont know if ill be able to get off the gabapentin since im on it technically for nueropathic pain.

Amphetamines can cause mania in some cases. It would be wise for you to try another anti-histamine as well besides diphenhydramine.

Guanfacine and amphetamines used in tandem can dose dependently negate each others effects, and in some cases have resulted in death. Guanfacine is usually prescribed to those on stimulants to aid in sleep and only that, so make sure you use it as prescribed. It's certainly a better option than benzodiazepines, but just be careful with it as I can't stress enough how potent it is.

Buproprion and amphetamines seems to be a hot combination that psychiatrists co-prescribe, so that maybe a wise idea to discuss with your new doctor. If the gabapentin is helping you with your neuropathic pain, stay on it, it synergizes well with amphetamines also.

 

[MMMMKAY?!]

Amphetamines can cause mania in some cases. It would be wise for you to try another anti-histamine as well besides diphenhydramine.

Guanfacine and amphetamines used in tandem can dose dependently negate each others effects, and in some cases have resulted in death. Guanfacine is usually prescribed to those on stimulants to aid in sleep and only that, so make sure you use it as prescribed. It's certainly a better option than benzodiazepines, but just be careful with it as I can't stress enough how potent it is.

Buproprion and amphetamines seems to be a hot combination that psychiatrists co-prescribe, so that maybe a wise idea to discuss with your new doctor. If the gabapentin is helping you with your neuropathic pain, stay on it, it synergizes well with amphetamines also.

So your saying that diphenhydramine and amphetamine weaken eachother? and that guanfacine and amphetamine together are dangerous but amphetamine with benzos are even more dangerous??

 

[MMMMKAY?!]

what do you g uys think would be the beta blocker or alpha agonist or any norepinephrine inhibitor with the least ammount of a negative effect on music?

 

[pasha]

No, I just don't think diphenhydramine is the best anti-histamine out there for use in psychiatric purposes. Guanfecine and amphetamines are dangerous from a cardiac point of view, but if taken correctly and not in tandem, they can work just fine. Many users of clonidine and amphetamines suffered cardiac arrest in some case reports, hence why I'm alerting you to this possible side effect. Benzodiazepines and amphetamines on the other hand, cause a viscous cycle were they become co-dependent in order to negate each others negative side-effects. Benzodiazepines are dangerous from an addiction, dependence, and withdrawal stand point.

what do you g uys think would be the beta blocker or alpha agonist or any norepinephrine inhibitor with the least ammount of a negative effect on music?

If you use these drugs, I'm almost certain the likely scenario is that they'll only be prescribed for sleep, so I don't really thing you have to worry about them tarnishing music appreciation. In the case were they're not, it would be very difficult to answer that question, and only you could determine it. Besides, there aren't really many adrenergic agonists that are co-prescribed with amphetamines other than clonidine and guanfecine.

As for the beta-blocker, I think you have another thread open to that, so it would be best to discuss it there as I think someones offered some advice already on the matter. Also, you should really be discussing these things with your doctor, especially recommendations for specific medications, because they know best, and they have your best interests at heart. Getting suggestions from your doctor and coming here for feedback would be the much healthier choice.

 

[MMMMKAY?!]

As for the beta-blocker, I think you have another thread open to that, so it would be best to discuss it there as I think someones offered some advice already on the matter..

My bad. I didn't even realize someone had put that as a seperate thread for me. x]

I know its been discussed slightly, but I have a new medication regime and would like to post what they are ad if anyone has had any changes with they're appreciation of music (postive or negative) I ask of you to please share your expierence . (Also of just any medication in general that's changed your appreciation for music) thanks very much the medication I am taking is: tenex 2mg a day, dexedrine 60mg a day, trazadone 50mg a day, diphenhydramine 50mg
your appreciation of music

Just so everyone knows I take, 400 mg gabapentin (nuerontin) three times a day and todday I took 800 at once ad definently felt MORE music appreciation
So I think nuerontin does icrease music appreciation (at least in me)

 

[pasha]

Pregabalin its sister drug definitely increases my appreciation for music.

 

[Siccness909]

Hydromorphone definitely gets me in that mood where EVERYTHING is perfect and my musical tastes are increased. As most opiates do, but the morph is just different for me..Pink Floyd dark side of the moon always in my playlist when I'm lifted.

 

[MMMMKAY?!]

How do you think pregabalin compares to gabapetin? Does it give yu those same muscle spasms?

 

[Midazle]

Yup Zoloft killed allot of my appreciation for music...I was also on a seizure medication when I was a kid and in combination with Zoloft it killed allot of my passion for things but helped me focus on school work. Its a damn shame but yeah...As for opioids...God I have some fond memory's of nodding off listening to Dark Side of the Moon! Its almost a requirement! Ah I remember when I wasn't tolerant I'd do like 10mg of Hydrocodone with 50mg of Diphenhydramine and maybe like 0.5 xanax and be in heaven...now a days for a similar if not better effect Ill do like 6mg of Hydromorphone with either 25mg benadryl or a tiny amount of Oxycodone and feel like all is right in the world...Hydromorphone is sooo noddy, I love it but I can't function on it so I'd usually reserve it for nighttime. Of course that is MY tolerance levels so you'd need to gauge your tolerance as Hydromorphone is nothing to mess with if your naive especially with other sedatives.

 

[MMMMKAY?!]

@midazle. I do thank you for all your inputs

 

[laCster]

How do you think pregabalin compares to gabapetin? Does it give yu those same muscle spasms?

pregabalin > gabapentin....

gabapentin is really annoying because literally results vary from day to day. one day i will be able to get a nice stonage from stacking gabapentin throughout the day, and literally the next day, absolutely fucking nothing...

lyrica is much much much reliable, and definitely not as volatile. tolerance grows rapidly, but you will be able to anticipate the effects from a certain dosage. say you need 450mgs to feel "good", the next time you take it 450mgs will do about the same thing it did for you the first time.

literally for gabapentin, one day i need 2500mg, the next day i need 6000mg, the next day i need 1000mg, and so on.... it is really hard to guess what it will feel like from gabapentin. unlike most other drugs where you know the dose you need, like say for oxycodone you usually need 45mgs, well maybe your tolerance grew, but the next time you know that you need somewhere around 45-55mg. again, with gabapentin literally you are trying to take a stab in the dark...

i still like gabapentin, but lyrica is much much better, and all around more reliable, potent, fun, ect...



marijuana makes music sound like shit to me...loool jk... i am trying really hard to abstain but thought it would be a good idea to buy some weed hahahaha. bought some and now i literally have that shit taped under my nose like a little weed-hitler starsh hahhaha and with every wiff, i feel a little stoned lmfao. i got something that i need to do tht requires me NOT to use, but on monday im getting soooooooooooooooooooooooooooooooooooooooooooooooooooooooooo baked to the bone baby!!!
umm alcohol makes music sound good aswell, while benzos kind of make it dull. they dont hinder appreciation, but usually im so zonked that i couldnt give two fucks what is playing hahaha

 

[Midazle]

@midazle. I do thank you for all your inputs

Yup no problem man! Just curious, why do you take Gabapentin? I tried Lyrica and I thought it was a pretty decent drug, Ive got severe Chronic pain and at one point when I was on Hydromorphone I needed more relief but was pretty sedated (16mg of Hydromorphone ER a day with not enough tolerance will do that to ya!) and I told the doctor I didn't want to bump the dose so I suggested Lyrica...it felt different then other seizure meds. Sort of like a Benzo with an interesting but subtle buzz...helped me relax a bit but didn't really help my pain..got be through benzo withdrawal real well though, I would have been toast without it then!

pregabalin > gabapentin....

gabapentin is really annoying because literally results vary from day to day. one day i will be able to get a nice stonage from stacking gabapentin throughout the day, and literally the next day, absolutely fucking nothing...

lyrica is much much much reliable, and definitely not as volatile. tolerance grows rapidly, but you will be able to anticipate the effects from a certain dosage. say you need 450mgs to feel "good", the next time you take it 450mgs will do about the same thing it did for you the first time.

literally for gabapentin, one day i need 2500mg, the next day i need 6000mg, the next day i need 1000mg, and so on.... it is really hard to guess what it will feel like from gabapentin. unlike most other drugs where you know the dose you need, like say for oxycodone you usually need 45mgs, well maybe your tolerance grew, but the next time you know that you need somewhere around 45-55mg. again, with gabapentin literally you are trying to take a stab in the dark...

i still like gabapentin, but lyrica is much much better, and all around more reliable, potent, fun, ect...

Really? I noticed Gabapentin felt pretty consistent dose to dose...600mg felt similar to 75-150mg of Lyrica. But Gabapentin made me feel cloudy in the head...it was weird...I took it out of curiosity one day when my mom stopped taking it for a similar reason. Idk my body is strange as hell when it comes to drugs....

 

[pasha]

In regards to your gabapentin vs pregabalin question, LaCster got it spot on. The main advantage pregabalin has over gabapentin is the consistent bioavailability which never changes depending on food, multi-dosing etc. It stays at a constant 90% orally making it a much more potent drug. Gabapentin however has a very unsteady bioavailability which is almost affected by anything and decreases in correlation to consistent dosing. Keep in mind though that pregabalin is much more expensive.

 

[Midazle]

In regards to your gabapentin vs pregabalin question, LaCster got it spot on. The main advantage pregabalin has over gabapentin is the consistent bioavailability which never changes depending on food, multi-dosing etc. It stays at a constant 90% orally making it a much more potent drug. Gabapentin however has a very unsteady bioavailability which is almost affected by anything and decreases in correlation to consistent dosing. Keep in mind though that pregabalin is much more expensive.

Ah I didn't even think about bioavailibility...that would make sense...Pregabalin is expensive though, I know gabapentin I always picked up generics but I always had to get the brand name Lyrica's...