• 💊 OTHER DRUGS 💊 Welcome Guest
    Posting Rules Bluelight Rules
    Notable Threads 1 Notable Threads 2
    Dangerous Combos Addiction Support
    Emergency Services Benzo Guide v.1
    Addiction Stories Scary Case Studies
    Biology, Pharmacology & Drugs 101
  • Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

RCs Anyone know about SR-14968? Does it let you detox without withdrawals the same as SR-17018?

T

Tetrapharmakos

Bluelighter
Joined
Nov 2, 2018
Messages
20
I used SR-17018 to get clean and it was a life saver after many failed detox attempts, zero acute withdrawals was miraculous.

What about SR-14968? The small amount of information i found was conflicting, wondering if it has similar effects, or is more of a traditional opiate?? It's cheaper than the former, wondering if I should have some on hand for potential future research or not.
 
@Smyth2 and @Skorpio pretty much covered this.


Above is a good index paper.

SR-17018 is a biased ligand and some reports suggest it produces less tolerance and dependence than classical opioids while others suggest it does not produce ANY tolerance or dependence. I'm uncertain if the tolerance and dependence liability can be measured with a single metric. Others may well know better than I.

Know what you have, go slow, accept it's still a research compound so we don't know as much as we need to assert safety. Respiratory depression may not be the side-effect that limits maximum dose.

I would like to know if it's a decent analgesic. I'm not looking for euphoria, but dysphoria might make me think a bit more. It seems around oxycodone in potency and has undergone at least some human trials. One paper notes that in man, the theraputic window was smaller that the initial paper stated... but I found the paper and it didn't explain why that might be the case.

BTW I'm a bit suspicious of how the original paper assigns extremely low theraputic windows for 'classic opioids' assigns very low TIs for fentanyl and morphine. So I feel you need to carefully read where those values were obtained or derived and note that they refer to animal models.
 
SR-17018 is great. I know from personal experience. What I'm wondering about is user reports for the other opioid RC, SR-14968, and if it shares the same benefits as SR-17 or not. Apparently testing in animals showed it did cause more tolerance/withdrawal than SR-17, which for me anyway caused zero withdrawal and seemed to reduce my tolerance.

SR-14968 has been available for sale for a little while now, but I'm having trouble finding consistent info on user reports. Some people claim it had terrible effects, others claimed it did help them detox but they needed to switch to SR-17 after, so they went from fentanyl to SR-14 to SR-17 to detox, but I am skeptical SR-14968 would have been necessary step at all.
 

@4DQSAR

But do you know when these compounds were first disclosed in the literature? 2017 is the earliest I’m seeing and it’s in academic papers. I’m particularly interested to know if there are any biotech companies developing them, if they are patented or not would give an insight into who the owner is and if they are still worth developing or optimizing.

If a company is working on them that’s where I could see something really great/legal/safe coming of these drugs.

can anyone do a structure search on sci finder?. If not searching the iupac name in google patent may (unlikely) give a result. I don’t want to even generate the iupac name using my software.
 
LucidSDreamr said:
@4DQSAR

But do you know when these compounds were first disclosed in the literature? 2017 is the earliest I’m seeing and it’s in academic papers. I’m particularly interested to know if there are any biotech companies developing them, if they are patented or not would give an insight into who the owner is and if they are still worth developing or optimizing.

If a company is working on them that’s where I could see something really great/legal/safe coming of these drugs.

can anyone do a structure search on sci finder?. If not searching the iupac name in google patent may (unlikely) give a result. I don’t want to even generate the iupac name using my software.
Click to expand...


The only structural differences between the two is the para halogen on the benzyl moiety and the addition of that methyl side-chain on the less biased compound.

Here's the thing - that side-chain makes the compound chiral but so far I've only found one patent in which the two enantiomers were resolved.
 
Tetrapharmakos said:
You can find the parents for SR-17018 on Pubmed here: https://pubchem.ncbi.nlm.nih.gov/compound/Sr-17018#section=Depositor-Supplied-Patent-Identifiers

Take this with a grain of salt but I read a comment I think on reddit claiming someone reached out to the patent holders for SR-17018 who are apparently in California, and they responded to say they had reached out to the US government about it's potential as a detox medications to aid the opioid crisis.
Click to expand...

Those authors are actually working out of Florida,s satellite facility of their institution but maybe the IP associate is based in the CA HQ of Scripps which they developed this under but was recently bought by university of Florida who is now the assignee.

Anyways it’s an academic institution the rights are assigned to; so not much is going to happen from that unless it’s been licensed to a drug company to push it through optimization and trials. I wonder if it’s licensed to a company yet, not sure how to check that off the top of my head.
 
You must log in or register to reply here.
Top