Anyone have any thoughts on my proposed stack

[KurtAurelius]

Morning (09:00)

Creatine (20g Morning)

Methylphenidate (as Concerta 72mg Morning)

Vitamin D3 (110ug Morning)

Folate (400ug Morning)

K2-MK7 (200ug Morning)

L-Citruline (6000mg Morning)

Omega 3 (1600mg roughly combined epa/dha from algae Morning)



Evening (21:00)

Magnesium L-Threonate (3000mg Evening)

Agamatine (3000mg Evening)

Glycine (3000mg Evening)

Theanine (400mg Evening)

Taurine (3200mg Evening)



1xWeekly (Monday)

Boron (10mg Morning)

Tocotrienols (125mg Morning)



2x Weekly (Monday/Friday)

CDP-Choline (500mg Morning)

Benfotiamine (500mg Morning)

Devised this for protecting my heart and keeping Methylphenidate effective for as long as possible…

And if a human would weigh in any thoughts,
I’ve skimmed the research Ai gave me but human thoughts always good.

 

[streaM Freak]

I know only a couple but I wonder, are there any that you cross off simply because they overlap in effects?

While the abuse potential isn't high, it's still a lot to take care of and keep track of, id personally be pretty overwhelmed.

Are any of those on your list new? Or have you used them all before in some way? @KurtAurelius

 

[KurtAurelius]

I know only a couple but I wonder, are there any that you cross off simply because they overlap in effects?

While the abuse potential isn't high, it's still a lot to take care of and keep track of, id personally be pretty overwhelmed.

Are any of those on your list new? Or have you used them all before in some way? @KurtAurelius

The ones you could cross off would be glycine I suppose, I’ve always found it hard to not push things to the limit but it’s doing similar to what Taurine Theanine and Agmatine are doing but just a little boost.. the citruline could be redundant but methylphenidate still increases blood pressure and pulse, and if I am going to be taking it for a while, I might aswell try and negate it.

I usually sit at 50-55 bpm at 24 years old with only walking and lifting weights lol


New additions are Citruline for blood flow and pressure mine is good still but I am going for longevity as I’ll be on stimulants indefinitely so long as my heart is healthy,

Omega 3 as I never get enough through diet and beneficial specifically apparently through my reading when your as Neurodiverse as I am.

Then Gylcine for additional NMDA modulation (tolerance and neurotransmitters)

The rest I’ve taken for a while, they are all there for Protection, tolerance and longevity..

I did reduce methylphenidate from 92mg to 18mg then to 36mg and stayed for a short while but quality of life was quite low compared to 54-72mg a day.

My appetite ( I have an undiagnosed binge eating thing I suspect) and mood is far better on a higher dose.

I can see how this is nightmarish but I’ve been taking things for years now, and I’ve reinforced it by knowing how I feel on versus off the supplements..

I know a lot of people think it’s bs etc, but I’ve conducted plenty of self experiments to know how worse I feel without them, my only caveat is I’ve never done bloodwork..

 

[streaM Freak]

If you feel better you feel better

I know you don't want to hear this necessarily but keep an open mind to other things too that aren't ingested! In other words, perhaps there isn't something about you that needs fixing.

 

[Allylbenzene]

It's a good stack, have you considered the other electrolytes besides magnesium?

Omega 3 (1600mg roughly combined epa/dha from algae Morning)

Omega 3 is tremendously popular but only because the adverts/marketing and scientific articles haven't payed much attention to it's known harmful effects. This quote gives a good insight on what I'm talking about:

In declaring omega 3 (EPA & DHA) to be safe, the FDA neglected to evaluate their anti-thyroid, immunosuppressive, lipid peroxidative, light sensitizing, and anti-mitochondrial effects, their depression of glucose oxidation, and their contribution to metastatic cancer, lipofuscinosis (age spots) and liver damage, among other problems.

It's not necessarily appropriate for longevity purposes.

In practical terms omega 3 have an anti-metabolic influence which will make ADHD worse. These fats promote an "overactive stress response which triggers adrenaline. Adrenaline gives people intelligence and enhances creativity but in excess causes hyperactivity, impulsivity and puts you in fight-or-flight mode which can be quite disruptive (eg overstimulation, racing thoughts, unfocused, anxiety, panic, brain fog etc). Classic ADHD symptoms.

For context, all the ADHD drugs reduce the effects of high adrenaline either directly (eg guanfacine) or indirectly (eg methylphenidate, adderall).

Glycine (3000mg Evening)

For some people glycine can cause stimulation because it's involved in activating the glutamate receptor (it's a co-agonist for the NMDA receptor). If you've not tried it in high doses be cautious.

 

[KurtAurelius]

It's a good stack, have you considered the other electrolytes besides magnesium?

Omega 3 is tremendously popular but only because the adverts/marketing and scientific articles haven't payed much attention to it's known harmful effects. This quote gives a good insight on what I'm talking about:



It's not necessarily appropriate for longevity purposes.

In practical terms omega 3 have an anti-metabolic influence which will make ADHD worse. These fats promote an "overactive stress response which triggers adrenaline. Adrenaline gives people intelligence and enhances creativity but in excess causes hyperactivity, impulsivity and puts you in fight-or-flight mode which can be quite disruptive (eg overstimulation, racing thoughts, unfocused, anxiety, panic, brain fog etc). Classic ADHD symptoms.

For context, all the ADHD drugs reduce the effects of high adrenaline either directly (eg guanfacine) or indirectly (eg methylphenidate, adderall).


For some people glycine can cause stimulation because it's involved in activating the glutamate receptor (it's a co-agonist for the NMDA receptor). If you've not tried it in high doses be cautious.

Thank you very much for your input Allyl,

I’m very conscious to drink plenty of Milk, and Orange Juice for both Potassium, and Calcium, I eat a lot of Dairy so the K2 is a protective thing to prevent any issues from high dairy consumption (sometimes 3 hefty servings a day, say 250g yoghurt, 100g cheese, 500ml milk)

Thanks again for Highlighting the Omega 3. I will do some more research again as you have pointed this out to me previously, I again get sucked in by the papers I get thrown at by AI

but I’ve not supplemented it for a long time. My eyesight has degraded so I wondered if in fact it did have utility for that, but it’s winter, and I’ve worsened my screen time habits. So an answer may instead be there.

I have tried high dose Glycine a few moons ago, I do think it made me feel weird actually and counter productive. I was considering axing it anyway as I’m unsure if it’s worth on top of the many agents already deployed at night. It got brought to my attention by AI and my memory of all the people throwing that one Megadose of Gylcine study and touting its “longevity” effects,

 

[Allylbenzene]

I’m very conscious to drink plenty of Milk, and Orange Juice for both Potassium, and Calcium, I eat a lot of Dairy so the K2 is a protective thing to prevent any issues from high dairy consumption

Sounds good.

Thanks again for Highlighting the Omega 3. I will do some more research again as you have pointed this out to me previously, I again get sucked in by the papers I get thrown at by AI

It's not something to rely on for serious queries as it doesn't actually understand anything.

but I’ve not supplemented it for a long time.

If you have previously taken it for a period of time then it might be worth taking measures to mitigate it's effects. They can persist and influence your present day-to-day. I imagine that the methylphenidate could be 'hiding' or 'covering up' any issues considering how it works as a stimulant.

 

[KurtAurelius]

You’ve already provided a ton of value, just to see if you have any final thoughts.

Although I change my mind like the wind, I’ve thought more and more about using a substance like methylphenidate and watching how it changes me.. i am remembering fondly older times where I did very well on a very strict diet and heavy adaptogenic stack with many pro metabolic agents like the ones I use now..

With the other information you’ve provided before, a new proposed stack could look like this..

Morning

Creatine (20g)

Caffeine from Tea (70-105mg)

Rhodolia (500mg)

Saffron (100mg)

Vitamin D3 (110ug)

Folate (400ug)

K2-MK7 (200ug)


Evening

Magnesium L-Threonate (3000mg)

Agamatine (3000mg)

Theanine (400mg)

Taurine (3200mg)

CBD+CBG (70mg)

1xWeekly (Monday)

Boron (10mg Morning)

Tocotrienols (125mg Morning)

2x Weekly (Monday/Friday)

CDP-Choline (500mg Morning)

Benfotiamine (500mg Morning)

There still of course is room for niacianmide and low dose aspirin..

 

[Allylbenzene]

...a new proposed stack could look like this..
Morning
Caffeine from Tea (70-105mg)
Rhodolia (500mg)
Saffron (100mg)

Good choice. The theanine in tea will help to balance the caffeine also.

Rhodiola reminds me of methylphenidate as they both boost dopamine and noradrenaline. Be careful combining those two things (it might be worth reducing your dose of methylphenidate).

Looking at what methylphenidates does (boosting dopamine and noradrenaline) - the dopamine reduces the negative effects of high adrenaline, whilst the noradrenaline reduces adrenaline directly (via it's action on the alpha-2 adrenergic receptor):

...noradrenaline enhances the working memory functions of the prefrontal cortex (PFC) through actions at post-synaptic, alpha-2A adrenoceptors.

(Quote from here)
So the common theme with all ADHD medications is lowering adrenaline. It's usually high because of an "overactive stress response" (stress triggers adrenaline).

I guess what I'm saying is that many of the things you're taking (or considering taking) overlap with methylphenidate, so keep in mind that you might be able to reduce the dose. For example, restoring metabolic function (see list below) will naturally restore your dopamine & energy levels and reduce stress (adrenaline).

Benfotiamine (500mg Morning)

There still of course is room for niacianmide and low dose aspirin..

I think niacinamide (vitamin B3) is underestimated by everyone in the longevity community. It's almost too basic for it to be deemed useful (aspirin too). Many of the things you're using I mentioned in my thread on reseting tolerances and general recovery/ADHD, here's the main things from the post:

• low-dose pregnenolone (regenerative via multiple mechanisms)
• low-dose thiamine (metabolic repair, w/carbs or honey)
• low-dose nicotinamide (metabolic repair, w/carbs or honey)
• very-low-dose aspirin (metabolic repair)
• theanine (calming, regenerates dopamine system)
• agmatine (multiple mechanisms)

Your benfotiamine is an analogue of thiamine (vitamin B1). I could have mentioned Rhodiola and caffeine as those are very beneficial but I wanted to keep it simple (+ they can be problematic for people who are going through drug cessation and recovery) ... but low-dose caffeine is one of the most effective remedies for metabolic repair alongside the above list.

 

[Jnowhere]

Morning (09:00)

Creatine (20g Morning)

Methylphenidate (as Concerta 72mg Morning)

Vitamin D3 (110ug Morning)

Folate (400ug Morning)

K2-MK7 (200ug Morning)

L-Citruline (6000mg Morning)

Omega 3 (1600mg roughly combined epa/dha from algae Morning)



Evening (21:00)

Magnesium L-Threonate (3000mg Evening)

Agamatine (3000mg Evening)

Glycine (3000mg Evening)

Theanine (400mg Evening)

Taurine (3200mg Evening)



1xWeekly (Monday)

Boron (10mg Morning)

Tocotrienols (125mg Morning)



2x Weekly (Monday/Friday)

CDP-Choline (500mg Morning)

Benfotiamine (500mg Morning)

Devised this for protecting my heart and keeping Methylphenidate effective for as long as possible…

And if a human would weigh in any thoughts,
I’ve skimmed the research Ai gave me but human thoughts always good.

Wow, you did some research into this.

I am amazed at how concerned you are about your health at 24 y.o.!

I wish I would have been. Good luck.

 

[streaM Freak]

@Allylbenzene - I appreciate all the value you are adding! And thank you for not "playing doctor" with telling others what to do - you are simply putting information on the table - it's interesting to hear the information you have gathered.

No rush and no pressure , but at some point I'd be very interested to hear how each one you've tried specifically helped you. For example how much you took and when, for what reasons, what it felt like, your analysis of the situation and such.

Cool