Opioids Anyone ever tried (or heard of, or have opinions on) plugging Loperamide?

[ChemicallyEnhanced]

Not saying/thinking it's gonna cause an opioid high, and I know you'd still need a lot, but at the very least it's gotta increase the BA? Like, you're bypassing both part of it being destroyed by stomach acid and then also first pass metabolism?

 

[helpingout]

Do it. I mean hoof it. I mean boof it. Report back

 

[RedRum OG]

Won't enhance the experience in any noticeable way.

BA orally isn't bad already (in the sense of getting to local GI receptors) and that route won't have significant effect on BBB crossing

And if you could, you wouldn't want to. My experiences with high dose loperamide were almost as bad as opiate withdrawals themselves - dizzy, sick, dry mouth worse than 200mg of cannabis edibles, dry eyes, confusion, dysphoria, and noticeable heart palpitations worse than IV coke, and I still felt 80% as opiate sick as I began on top of all that.

I've tried a lot of fiddling with it, and no matter what, I find it shines best in medium doses, not high ones

 

[ghostbagel666]

i wasn’t aware that lope could cross the blood brain barrier and that taking too much of it to try and do exactly that is just going to really send you into a world of hurt featuring hits (including but not limited to) like: severe constipation, stomach cramps and nausea.


i really wouldn’t try it… i know if it was me and i tried it then with my luck id end my aşş up in the ER suffering hardcore.

 

[ChemicallyEnhanced]

Do it. I mean hoof it. I mean boof it. Report back

No, I mean dissolved in liquid and done with an oral syringe.

 

[ChemicallyEnhanced]

Won't enhance the experience in any noticeable way.

BA orally isn't bad already (in the sense of getting to local GI receptors) and that route won't have significant effect on BBB crossing

And if you could, you wouldn't want to. My experiences with high dose loperamide were almost as bad as opiate withdrawals themselves - dizzy, sick, dry mouth worse than 200mg of cannabis edibles, dry eyes, confusion, dysphoria, and noticeable heart palpitations worse than IV coke, and I still felt 80% as opiate sick as I began on top of all that.

I've tried a lot of fiddling with it, and no matter what, I find it shines best in medium doses, not high ones

The oral BA of Loperamide is less than 1%. I would call that very bad.

 

[ChemicallyEnhanced]

i wasn’t aware that lope could cross the blood brain barrier and that taking too much of it to try and do exactly that is just going to really send you into a world of hurt featuring hits (including but not limited to) like: severe constipation, stomach cramps and nausea.


i really wouldn’t try it… i know if it was me and i tried it then with my luck id end my aşş up in the ER suffering hardcore.

For some reason I just do not get constipation ever. In the past I've taken like 60-80mg for 3 or 4 days in a row and still pooped every day.

 

[ChemicallyEnhanced]

i wasn’t aware that lope could cross the blood brain barrier and that taking too much of it to try and do exactly that is just going to really send you into a world of hurt featuring hits (including but not limited to) like: severe constipation, stomach cramps and nausea.


i really wouldn’t try it… i know if it was me and i tried it then with my luck id end my aşş up in the ER suffering hardcore.

Also, I feel like ANYTHING is better than opioid withdrawal. Even if I were to fully go into cardiac arrest, I'd pick that over the withdrawal; every time.

 

[ghostbagel666]

For some reason I just do not get constipation ever. In the past I've taken like 60-80mg for 3 or 4 days in a row and still pooped every day.

ooof, i still would not chance it by taking higher dosss. you never know when your body is going to revolt… and severe constipation is the literal worst thing ever trying go get out. like if you can’t do it yourself (which is definitely definitively a possibility… there’s been a few times just from when i was on subs that i got dangerously close to needing “outsider help” from the hospital) you can’t just leave it and hope for the best, you’ll eventually need emergency medical intervention which that to me would be the worse thing ever and i would be permanently damaged mentally from having to do that.

i mean its totally up to you what you do, but if youre taking advice and votes- write me in as “hell no.”

best of luck to you either way!

 

[ghostbagel666]

Also, I feel like ANYTHING is better than opioid withdrawal. Even if I were to fully go into cardiac arrest, I'd pick that over the withdrawal; every time.

i mean i can handle a certain amount amount of opiate WDS… i do get to my point though, so i understand where you’re coming from.

i just personally have given birth, to a literal child, and from subutex i’ve had such severe constipation that what came out of me was WAY WAAAAAY WORSE than giving birth. and i was technically in labor for a week and a half in the hospital and the first few days they had to stop my labor and quarantine me in a labor and delivery room because my WBC and fever spiked so high in such a short amount of time that the hospital i was at (the best in texas for delivering a baby, but also was the hospital that took care of the man with ebola a time back and had the ebola scare- so they truly do NOT fuck around with any type of infectious diseases) they believed that i had some sort of super rare infectious disease and the only way to protect myself and my baby (and in part my abusive ex who happened to be trapped in the room with me during this since he was there when i came down with it)was to halt my delivery so i didn’t pass on whatever i had to him during delivery and they also were worried that if they attempted to have me deliver that i would very likely die in my condition and could also pass on whatever super severe scary infectious disease i had onto whatever doctors and nurses that did the c-section on me. they sealed off my room and only one nurse from each shift was designated and allowed into my room in full PPE hazmat wear to administer my IV morphine and vicodin because i was in such excruciating pain. i was in there for 3 days while they ran every test known to mankind on me that they could… and the fucking CDC sent out doctors to try and figure out what was going on with me and they came in again in scary PPE hazmat suits as well and they checked me over too. finally after 4 days my high fever broke and my WBC that was fucking astronomical came back down to this planet to a good level and they finally allowed me out of that labor and delivery room and moved me up to the maternity ward for nearly another whole week. they said that i didn’t have an infectious disease at all apparently my body was just reacting to the excruciating pain i was in from my son sitting on my sciatic never which was what was causing the excruciating pain and my inability to walk anywhere at all or put any pressure whatsoever on my feet or legs. i couldn’t even have anything not even a light sheet, pants
, or underwear touching my legs without me sobbing and screaming hysterically for hours afterwards. my body reacted to the pain thinking something was seriously wrong and threw every defense it could at it. including my white blood cell count spiking and the fever. it literally did not know how to react to that kind of pain.

and yet there are some moments i’ve spent on the toilet, cursing god, from being on subutex long term where what came out of me- it coming out… was more painful than literally childbirth. it came very very close a couple of times to me screaming out for help for my husband to get me to the hospital when finally FINALLY the demon in the form of constipation inside me decided to figure its way out of me (while i screamed cried and bled the entire way out… which i guess isn’t too far from my acting childbearing experience as well either LMFAO)

 

[ChemicallyEnhanced]

ooof, i still would not chance it by taking higher dosss. you never know when your body is going to revolt… and severe constipation is the literal worst thing ever trying go get out. like if you can’t do it yourself (which is definitely definitively a possibility… there’s been a few times just from when i was on subs that i got dangerously close to needing “outsider help” from the hospital) you can’t just leave it and hope for the best, you’ll eventually need emergency medical intervention which that to me would be the worse thing ever and i would be permanently damaged mentally from having to do that.

i mean its totally up to you what you do, but if youre taking advice and votes- write me in as “hell no.”

best of luck to you either way!

That's fair - we all have different things that are our "Fuck No!"'s. Like, mine was having a catheter put into my bladder via my no-no parts. But back when I first got pancreatitis I was so extremely ill I don't think I even noticed I had one in until weeeks later. And then needed one on and off for flare-ups.
Then I was like "meh" and even once drank A LOT (not alcohol) and help it in* and pretended I couldn't bee and ASKED them to put one in as an excuse to stay in hospital. That time, though, of all nurses they had to pick THE hottest one to do it.
Or, like lasik...I just couldn't handle it.

I do coffee enema's sometimes, anyway, so I guess if I ever DID become severe constipated, I could just do that. Or do it water. Or milk, actually. Apparently the lactose and sugar in the milk makes you shit like crazy.

 

[ChemicallyEnhanced]

i mean i can handle a certain amount amount of opiate WDS… i do get to my point though, so i understand where you’re coming from.

i just personally have given birth, to a literal child, and from subutex i’ve had such severe constipation that what came out of me was WAY WAAAAAY WORSE than giving birth. and i was technically in labor for a week and a half in the hospital and the first few days they had to stop my labor and quarantine me in a labor and delivery room because my WBC and fever spiked so high in such a short amount of time that the hospital i was at (the best in texas for delivering a baby, but also was the hospital that took care of the man with ebola a time back and had the ebola scare- so they truly do NOT fuck around with any type of infectious diseases) they believed that i had some sort of super rare infectious disease and the only way to protect myself and my baby (and in part my abusive ex who happened to be trapped in the room with me during this since he was there when i came down with it)was to halt my delivery so i didn’t pass on whatever i had to him during delivery and they also were worried that if they attempted to have me deliver that i would very likely die in my condition and could also pass on whatever super severe scary infectious disease i had onto whatever doctors and nurses that did the c-section on me. they sealed off my room and only one nurse from each shift was designated and allowed into my room in full PPE hazmat wear to administer my IV morphine and vicodin because i was in such excruciating pain. i was in there for 3 days while they ran every test known to mankind on me that they could… and the fucking CDC sent out doctors to try and figure out what was going on with me and they came in again in scary PPE hazmat suits as well and they checked me over too. finally after 4 days my high fever broke and my WBC that was fucking astronomical came back down to this planet to a good level and they finally allowed me out of that labor and delivery room and moved me up to the maternity ward for nearly another whole week. they said that i didn’t have an infectious disease at all apparently my body was just reacting to the excruciating pain i was in from my son sitting on my sciatic never which was what was causing the excruciating pain and my inability to walk anywhere at all or put any pressure whatsoever on my feet or legs. i couldn’t even have anything not even a light sheet, pants
, or underwear touching my legs without me sobbing and screaming hysterically for hours afterwards. my body reacted to the pain thinking something was seriously wrong and threw every defense it could at it. including my white blood cell count spiking and the fever. it literally did not know how to react to that kind of pain.

and yet there are some moments i’ve spent on the toilet, cursing god, from being on subutex long term where what came out of me- it coming out… was more painful than literally childbirth. it came very very close a couple of times to me screaming out for help for my husband to get me to the hospital when finally FINALLY the demon in the form of constipation inside me decided to figure its way out of me (while i screamed cried and bled the entire way out… which i guess isn’t too far from my acting childbearing experience as well either LMFAO)

Damn, I'm sorry you had such a traumatic-sounding child-birth experience.
But better outcome than the horrible constipation? Resulting in a baby gotta be better than resulting in a turd.

I remember many, many years ago having that painful type of constipation where the poop is huge and hard and dry and actually feels fucking SHARP. Definitely a bad experience.