Kratom Any serious interactions between rosuvastatin and Kratom/Kratom extracts (Not 7-OH)? What about alcohol with rosuvastatin?

[Mycophile]

So, unfortunately I have to start taking 10mg of rosuvastatin/crestor for high cholesterol. I looked it up and from what most sites say there doesn't SEEM to USUALLY be any major interactions between the Kratom and this drug.

One site said:

Kratom & Statin Drugs​

"Kratom and statin drugs have a low chance of producing side effects when used in combination.

Statins are a class of drugs that block an enzyme in the liver called HMG-CoA reductase. This enzyme is responsible for producing cholesterol — so these medications are used to treat high cholesterol.

Kratom may interfere with the metabolism of statin drugs via the CYP3A4 enzymatic pathway, but there are no cases of this interaction causing any problems.

With that said, it’s wise to speak to your doctor about using kratom if you’ve been prescribed statin medications to manage your cholesterol levels."

List of Common Statin Medications​

• Atorvastatin (Lipitor)
• Lovastatin (Altoprev)
• Pitavastatin (Livalo, Zypitamag)
• Pravastatin (Pravachol)
• Rosuvastatin (Crestor & Ezalor)
• Simvastatin (Zocor)

That doesn't sound too bad, but the AI overview said:

"Combining Kratom and Rosuvastatin (Crestor) may lead to drug interactions and should be approached with caution and under the guidance of a healthcare professional.
Kratom is known to inhibit certain cytochrome P450 (CYP) enzymes, particularly CYP2D6 and CYP3A, which are responsible for metabolizing a significant portion of medications, according to the National Institutes of Health (NIH). Rosuvastatin is primarily metabolized by CYP2C9 and minimally by CYP2C19, says the NIH. Additionally, rosuvastatin relies on the transporter protein OATP1B1 for absorption into the liver.
While rosuvastatin itself is not primarily metabolized by the enzymes significantly inhibited by Kratom (CYP2D6 and CYP3A), there is still a potential for interaction due to Kratom's effects on other enzymes and transporters, or due to other less understood mechanisms.
Specifically, Kratom has been shown to potentially inhibit multiple cytochromes P450 (CYPs), including CYP2C9, according to the National Institutes of Health (NIH). Since CYP2C9 plays a role in rosuvastatin metabolism, there's a theoretical risk of increased rosuvastatin levels when combined with Kratom. Higher levels of rosuvastatin could increase the risk of side effects like muscle pain or weakness, and potentially more serious conditions like rhabdomyolysis.
Therefore, it is crucial to consult with your doctor or pharmacist before combining Kratom with rosuvastatin or any other medication. They can assess your individual risk factors and determine the safest course of action.
Important Note: The information provided here is for general understanding and does not replace professional medical advice. Always consult with a healthcare professional regarding any concerns about medication interactions."



So, it's POSSIBLE that Kratom could increase the levels of rosuvastatin in my bloodstream and Higher levels of rosuvastatin could increase the risk of side effects like muscle pain or weakness, and potentially more serious conditions like rhabdomyolysis.




But really, how likely is that to happen? Doesn't seem that likely to me. Has anyone here taken any statin drugs with Kratom?

Also, I was told by my last doctor that it IS relatively safe to drink (even heavily) on statins, and I know people who drink on them, but multiple sites are saying that's a risk for liver damage. I believe my doctor over the sites. I'm assuming that you COULD get liver problems from massive amounts of booze with statins cause you already can get that from alcohol, but I wouldn't assume it's going to happen. What do people think about the alcohol and statin combo?

 

[Mycophile]

This link makes me not TOO worried about alcohol + rosuvastatin. I mean the risk of liver damage is there, but I already know some people who drink heavily on their statin, and I'm not some hardcore alcoholic. I usually don't even have 1 drink per week, but sometimes I go on heavy binges like when on vacation, so I guess that's something to be aware of. I don't want muscle breakdown or rhabdomyolylis:

Is It Safe to Mix Statins and Alcohol?

Mixing statins and alcohol might be risky if you have a history of heavy drinking.

www.healthline.com

 

[Skorpio]

The muscle pain from statins is gonna be dose dependent, you could decrease your dose to 3/4 and assess. Have you experienced that muscle pain on the statin alone?

 

[Mycophile]

The muscle pain from statins is gonna be dose dependent, you could decrease your dose to 3/4 and assess. Have you experienced that muscle pain on the statin alone?

I haven't started yet. Tonight will be my first dose of 10mg Rosuvastatin, which I hear is a low dose.

I'm less concerned about Kratom and more about alcohol, but a doctor once told me i didn't really need to be concerned. I said "even if I get drunk/drink heavily" and he said "no." But there are stories of people online saying drinking on a statin has DRAMATICALLY worsened their hangovers, and I already get bad hangover since i'm on Klonopin (I know, I know, not great.) There are a number of sites which say heavy drinking on statins can cause liver damage, but many other sites say that even in that case it's extremely rare. I don't know about the muscle soreness and kidney stuff....

I mean MOST of the year my alcohol use isn't too bad, but when I go on vacation (which is coming up in a few weeks) I will usually get drunk 2-3 times a week. I think I will probably not do as much drinking this year, but I can't be on a drug where getting drunk is likely to kill me. Then again, they say I need this drug or I'm at risk for a cardiac event, even being relatively healthy and 45 which isn't THAT old. Just fucking genetic high cholesterol....

 

[Mycophile]

And also, what if i skipped a dose of my statin if i was drinking heavily? Would that help? Ditto for the Kratom but again, I'm less concerned about that.

 

[Skorpio]

I can’t speak one way or another to the liver toxicity of statins and alcohol. It should be ok to stop statins briefly though.

The muscle soreness is due to increased oxidative stress in muscle cells. This mechanism of action occurs in the heart, but rather than being harmful, it kicks antioxidant production into high gear and this effect is likely as big or bigger a contributor to the cardioprotection of statins than their lowering of cholesterol.

 

[Mycophile]

I can’t speak one way or another to the liver toxicity of statins and alcohol. It should be ok to stop statins briefly though.

The muscle soreness is due to increased oxidative stress in muscle cells. This mechanism of action occurs in the heart, but rather than being harmful, it kicks antioxidant production into high gear and this effect is likely as big or bigger a contributor to the cardioprotection of statins than their lowering of cholesterol.

Ok, but why don't you have an opinion on mixing statins with alcohol? If you don't have one I'd like to hear from anyone on here who drinks while taking them because I know it's a risk but I really want to know how big a risk it is cause I can't imagine never getting drunk again.

And what about Kratom?

 

[SuperPsych]

"Kratom is known to inhibit certain cytochrome P450 (CYP) enzymes, particularly CYP2D6 and CYP3A, which are responsible for metabolizing a significant portion of medications, according to the National Institutes of Health (NIH). Rosuvastatin is primarily metabolized by CYP2C9 and minimally by CYP2C19, says the NIH"

I'm no doctor but this makes me believe that the combination should be safe. I think that kratoms inhibition of certain enzymes is it's biggest risk with taking kratom. I know that it makes DXM way stronger. Enough for 30mg to have a noticeable effect.
I mean there IS 7-OH which is less murky in it's pharmacology than kratom, but I would avoid it if kratom does end up being safe. It is an option though. We'll see how for how long it's available though as they're considering making 7-OH a schedule 1 drug in the United States. I do think that the explosion in availability of 7-OH is not good but I hope that 7-OH doesn't get scheduled, and if it does, that it doesn't effect the availability of kratom.

Anyways, to me it seems like Kratom would be okay to take with it. Just be cautious taking other medications considering that both the kratom and rosuvastatin both inhibit different enzymes

 

[Mycophile]

"Kratom is known to inhibit certain cytochrome P450 (CYP) enzymes, particularly CYP2D6 and CYP3A, which are responsible for metabolizing a significant portion of medications, according to the National Institutes of Health (NIH). Rosuvastatin is primarily metabolized by CYP2C9 and minimally by CYP2C19, says the NIH"

I'm no doctor but this makes me believe that the combination should be safe. I think that kratoms inhibition of certain enzymes is it's biggest risk with taking kratom. I know that it makes DXM way stronger. Enough for 30mg to have a noticeable effect.
I mean there IS 7-OH which is less murky in it's pharmacology than kratom, but I would avoid it if kratom does end up being safe. It is an option though. We'll see how for how long it's available though as they're considering making 7-OH a schedule 1 drug in the United States. I do think that the explosion in availability of 7-OH is not good but I hope that 7-OH doesn't get scheduled, and if it does, that it doesn't effect the availability of kratom.

Anyways, to me it seems like Kratom would be okay to take with it. Just be cautious taking other medications considering that both the kratom and rosuvastatin both inhibit different enzymes

Thanks. But what about alcohol? That seems riskier, but I just can't see myself not drinking sometimes, and by drinking, I mean getting drunk.

As far as 7-OH, I won't touch that stuff. I've heard it's just WAY too addictive. I will use strong extracts like OPMS black etc, but honestly, I have found the withdrawal from that to not only NOT be worse than that from plain leaf, but sometimes to be milder.

The AKA recently put out a newsletter saying that they SUPPORT the banning of 7-OH because they believe that 1) it's too dangerous/addictive 2) that it will actually STRENGTHEN their pro-plain leaf/milder extracts kratom-stance because it will show that they aren't just "okay with anything." They are asserting that 7-OH isn't real Kratom. Honestly, I see their point, and while I don't believe 7-OH should be banned (I mean, I'm for legalization of ALL drugs), I think that if it is it will not necessarily affect plain leaf Kratom/milder extracts at all. I mean, it also might, and I could get worried about that, but I'm choosing not to. Based on how things have worked so far, I don't think a ban on 7-OH necessarily = any kind of ban on plain leaf/milder extracts, but I am concerned it could be a slippery slope. We'll just have to see.

 

[Mycophile]

I can’t speak one way or another to the liver toxicity of statins and alcohol. It should be ok to stop statins briefly though.

The muscle soreness is due to increased oxidative stress in muscle cells. This mechanism of action occurs in the heart, but rather than being harmful, it kicks antioxidant production into high gear and this effect is likely as big or bigger a contributor to the cardioprotection of statins than their lowering of cholesterol.

Could you please comment on my last question? If you really don't have any opinion or knowledge of whether or not drinking on statins is too dangerous, then I guess that's fair. I keep seeing sites saying that it's "fine in moderation" but dangerous with heavy drinking, and I am certainly going to have times I do drink heavily. I mean it's PURE anecdote, but some guy on Reddit was saying he drinks heavily on his statin which is a different type but same dosage as mine at 10mg which is low. But then there are plenty of people saying it worsens their hangovers. I don't know. I'm going on vacation in a few weeks and I just started taking my statin and there's little chance that I won't be getting drunk at least a few times. I'll attempt to be "careful," but I'm not quite sure what that means here....

At the VERY LEAST I think that PROBABLY at worst I'd feel bad from the combo FIRST and notice that rather than having it just immediately cause some massive liver or kidney damage, would you not agree?

Cause I just want to be able to "feel this out" and see how my body reacts to alcohol and Kratom while on statins. If I have no choice but to be on this shit (and my doctor says I don't) then I need to know how it affects me with my recreational drugs of choice. I REALLY dread to think of what it would be like to find out that I can only have a few drinks and that otherwise I'll be risking my life, cause I'm not willing to risk my life, but LIFE without EVER being able to get drunk and just having to "moderate" which I usually can't do? That would suck beyond belief.

 

[SuperPsych]

Thanks. But what about alcohol? That seems riskier, but I just can't see myself not drinking sometimes, and by drinking, I mean getting drunk.

If you mean the possible dangers of combining alcohol with rosuvastatin, then I can't speak on that as I don't know anything really about rosuvastatin. If your doctor says that it is relatively safe to drink while on rosuvastatin, then I would take his word for it. Though this is good reason to try your best not to drink too heavily or too often. If you drink regularly then I'd try not to get drunk often. If you like to get drunk then I'd try not to drink regularly. Basically if there is a possibility of liver damage, then it's probably best to choose to drink lightly but regularly or get drunk occasionally. Obviously its best to not drink but I'd just try your best to avoid alcoholic patterns of drinking.

The AKA recently put out a newsletter saying that they SUPPORT the banning of 7-OH because they believe that 1) it's too dangerous/addictive 2) that it will actually STRENGTHEN their pro-plain leaf/milder extracts kratom-stance because it will show that they aren't just "okay with anything." They are asserting that 7-OH isn't real Kratom. Honestly, I see their point, and while I don't believe 7-OH should be banned (I mean, I'm for legalization of ALL drugs), I think that if it is it will not necessarily affect plain leaf Kratom/milder extracts at all. I mean, it also might, and I could get worried about that, but I'm choosing not to. Based on how things have worked so far, I don't think a ban on 7-OH necessarily = any kind of ban on plain leaf/milder extracts, but I am concerned it could be a slippery slope. We'll just have to see.

I personally don't support the banning of 7-OH due to the fact that I believe in the legalization and control of all drugs, though I do really hate how common and advertised that 7-OH is. I can't hop on Facebook without seeing a dozen ads for it. I'm worried about 7-OH giving Kratom a bad name and leading to the banning of kratom itself. I've struggled on and off for over a decade with kratom addiction but I still would like for it to remain legal. Getting addicted to it was my doing. That doesn't mean that other people shouldn't have access to it. That's the stance that I have on all drugs. I think that if people wanna go to the store and get some meth or heroin then they should be able to with out persecution or judgement.

Anywho, there are definitely going to be a large amount of people who started using 7-OH without really knowing what it was that are going to end up with a nasty opioid addiction which is a damn shame, but also falls on them for either not researching or going against warnings.

 

[Skorpio]

Could you please comment on my last question? If you really don't have any opinion or knowledge of whether or not drinking on statins is too dangerous, then I guess that's fair. I keep seeing sites saying that it's "fine in moderation" but dangerous with heavy drinking, and I am certainly going to have times I do drink heavily. I mean it's PURE anecdote, but some guy on Reddit was saying he drinks heavily on his statin which is a different type but same dosage as mine at 10mg which is low. But then there are plenty of people saying it worsens their hangovers. I don't know. I'm going on vacation in a few weeks and I just started taking my statin and there's little chance that I won't be getting drunk at least a few times. I'll attempt to be "careful," but I'm not quite sure what that means here....

At the VERY LEAST I think that PROBABLY at worst I'd feel bad from the combo FIRST and notice that rather than having it just immediately cause some massive liver or kidney damage, would you not agree?

Cause I just want to be able to "feel this out" and see how my body reacts to alcohol and Kratom while on statins. If I have no choice but to be on this shit (and my doctor says I don't) then I need to know how it affects me with my recreational drugs of choice. I REALLY dread to think of what it would be like to find out that I can only have a few drinks and that otherwise I'll be risking my life, cause I'm not willing to risk my life, but LIFE without EVER being able to get drunk and just having to "moderate" which I usually can't do? That would suck beyond belief.

skimming a few papers, I found a mechanistic study which showed that there seems to be some increased risk for strokes and cerebrovascular events, but an epidemiological study indicated lower levels of cirrhosis and hepatocellular carcinoma among statin using heavy drinkers than those who didn’t use statins.

I don’t think there is a ton of research on this so there is likely no super precise answer. It doesn’t look extremely acutely harmful compared to just drinking a lot alone.

Of course polypharmacology complicates things, so the combination of alcohol, kratom, and a statin could be more side effect prone than any combination of the two.

 

[Mycophile]

If you mean the possible dangers of combining alcohol with rosuvastatin, then I can't speak on that as I don't know anything really about rosuvastatin. If your doctor says that it is relatively safe to drink while on rosuvastatin, then I would take his word for it. Though this is good reason to try your best not to drink too heavily or too often. If you drink regularly then I'd try not to get drunk often. If you like to get drunk then I'd try not to drink regularly. Basically if there is a possibility of liver damage, then it's probably best to choose to drink lightly but regularly or get drunk occasionally. Obviously its best to not drink but I'd just try your best to avoid alcoholic patterns of drinking.


I personally don't support the banning of 7-OH due to the fact that I believe in the legalization and control of all drugs, though I do really hate how common and advertised that 7-OH is. I can't hop on Facebook without seeing a dozen ads for it. I'm worried about 7-OH giving Kratom a bad name and leading to the banning of kratom itself. I've struggled on and off for over a decade with kratom addiction but I still would like for it to remain legal. Getting addicted to it was my doing. That doesn't mean that other people shouldn't have access to it. That's the stance that I have on all drugs. I think that if people wanna go to the store and get some meth or heroin then they should be able to with out persecution or judgement.

Anywho, there are definitely going to be a large amount of people who started using 7-OH without really knowing what it was that are going to end up with a nasty opioid addiction which is a damn shame, but also falls on them for either not researching or going against warnings.

Yeah, we are in total agreement on this stuff. And it's precisely because the AKA is worried that 7-OH will give Kratom a bad name that they want it banned. I don't support it being banned, but I definitely want regular Kratom to stay legal.

 

[Mycophile]

skimming a few papers, I found a mechanistic study which showed that there seems to be some increased risk for strokes and cerebrovascular events, but an epidemiological study indicated lower levels of cirrhosis and hepatocellular carcinoma among statin using heavy drinkers than those who didn’t use statins.

I don’t think there is a ton of research on this so there is likely no super precise answer. It doesn’t look extremely acutely harmful compared to just drinking a lot alone.

Of course polypharmacology complicates things, so the combination of alcohol, kratom, and a statin could be more side effect prone than any combination of the two.

Thanks. Yeah, it's hard to know. Certainly it's not easy on the liver, but most of what I've read seems to say that the problem is mostly with heavy drinking. And I don't usually drink on Kratom, but there probably will be a few times I will. More often I use Kratom to recover from hangovers, but that still probably is heavy on the liver cause your body is still processing the alcohol.

I guess I'm just going to have to find out for myself by drinking and taking Kratom, because I know I'm going to. I mean, you'd have to literally tell me that it's COMPLETELY contraindicated to stop me. They've always said never to drink on Klonopin or prozac, but here I am after decades of drinking on both. That's not to say that that isn't bad for you or that anyone should. Maybe I'll report back when I see how things go.

 

[chippermonk]

It's important to consider that statins reduce CoQ10 production. A CoQ10 supplement would be helpful.
Since statins reduce cholesterol production this reduces the production of protective hormones (see below). Of the 3 shown below, progesterone is a potent GABA-A PAM. Less progesterone means less calming GABA-A activity, so it might be worth considering a safe pro-GABA alternative like Magnolia (magnolol/honokiol) or theanine.

I have heard about it being helpful to take CoQ10 if you are in the minority of people who have muscle pains with statins, but how does that relate to GABA? And just what does GABA do, why is it important, etc?
I'm personally annoyed because they told me to take statins even though my cholesterol was pretty good and my risk factors low EXCEPT for the fact that heart disease runs in my family and imaging shows low level arteriosclerosis. They persuaded me to take it but I'm annoyed and wonder about the negative effects.
And now I have to wonder if my kratom is interacting with it? Fuck that.
Thanks

 

[Allylbenzene]

I have heard about it being helpful to take CoQ10 if you are in the minority of people who have muscle pains with statins, but how does that relate to GABA? And just what does GABA do, why is it important, etc?
I'm personally annoyed because they told me to take statins even though my cholesterol was pretty good and my risk factors low EXCEPT for the fact that heart disease runs in my family and imaging shows low level arteriosclerosis. They persuaded me to take it but I'm annoyed and wonder about the negative effects.
And now I have to wonder if my kratom is interacting with it? Fuck that.

This article will give you some insights about cholesterol: https://raypeat.com/articles/articles/cholesterol-longevity.shtml

The body makes cholesterol as a precursor for hormones (amongst other things).
Mitochondria turn cholesterol into hormones. They need T3 (active thyroid hormone) to do that properly.
These hormones have various effects (neurogenesis, protection from stress, muscle anabolism etc).

(image from here)

Cholesterol is a precursor for all hormones:

IMO anyone using statins should take CoQ10 and consider other strategies to make up for reduced hormone production.
Statins stop more than just the production of cholesterol:

Throw in a statin and what do you have –
inevitable inhibition of dolichol synthesis, roughly comparable to the
degree of cholesterol inhibition. The resulting effect upon our body of
this dolichol theft is completely unpredictable for this is the very
center of cell communication and immunodefense. We now know that dolichol
inhibition is fully as important as CoQ10 in this game of statin roulette
with a range of side effect that we are only just beginning to know. And
mind you, CoQ10 and dolichols are just a part of statin's biochemical
effect.

https://www.bmj.com/rapid-response/2011/11/01/re-patients-viewpoint