Miscellaneous Any new, interesting psychedelic scaffolds been developed?

[izo]

I guess I tend to resist arguments that nature is complete or better than non-nature. We have compounds formed from amino acids because of the similarity to neurotransmitters, but plenty of good drugs have no similarity to the endogenous ligands which bind the same receptors (ie morphinan opiates, anti-histamines, and GABA PAMs.) Hell arylcyclohexylamines have activity (NMDA antagonism) for which there isn't a known endogenous analog.

absolutely agree sir, but when it comes to proper halucinogens i think the scaffolds are limited.

 

[HOOH]

OP here, damn, this thread turned out to be amazing. Thanks for everyone who's contributed so far, and especially seeing the Orr paper detailing literally hundreds of different psychedelics was amazing to see, BCiHKAL when?

Morris has already bragged on twitter about their in silico stuff yielding many compounds

Has he? Can you find a tweet on that?

 

[Moldy Plates]

Has he? Can you find a tweet on that?

Hmm, I can't. Thought it was there, was not. IDK what I was thinking of or if I'm imagining things.