Dissociatives Any new info on Isophenidine (a.k.a. isopropylphenidine / NPDPA) ?

[Phencyclidine-MXE]

I know a vendor who recently started offering up Isophenidine.

Years ago I tried Diphenidine and Ephenidine ... But only had a little experience with them, I didn't get into em all that much because at the time I had stuff like 3-meo-pcp and DCK still available to me.

Ive read what little I could find on here about It. That and a couple Reddit posts was all I found about it, period.

Seems like it might have more similarities to ACH's unlike the other diarylethylamines. It has piqued my interest since I know someone who has it.

So... Has anybody else tried it? Any more info anyone could give me about it?

And if you happen to know the vendor I'm talking about... Are you planning on getting any?

I would appreciate any possible input.

Thanks.

 

[Asante]

N-isopropyl-alpha-phenylphenethylamine.

Not something I'd like to try. The phenidines have caused fatalities and this is one with an N-isopropyl group to make it more metabolically stable.

I think it will be "available" more than it is good.

 

[Allylbenzene]

There's a thread by the person who was involved in designing it.

Also:

It's the balance of NMDA antagonism and DRI that are key. You have to balance those two disparate actions.

We produced methoxyphenidine and while more potent than isophenidine, it wasn't orders of magnitude more potent as far as I know, just twice the potency.

 

[Endo G]

I have not heard of and am out of the loop of vendors for a few years….however, I am about wrapping up the last of my ephenidine, and think that material has lower dosage potential for a functional/contemplation material that seems to provide a release for stress etc and a bit of an afterglow.

a bit concerned about cardiac stuff with this class, never tried diphenedine. I took low doses of ephenidine for 3 days with the first night being very low, like 10 mg as a tester. On the 4th day had an annoying chest sensation that had me worried and hadnt taken anything but regular bupropion/10mg adderral . But I had an inkling maybe stopping supplements of D3 thru last winter was a mistake, started supplementing and the next day the chest sensations were gone. A year later this winter Ive done around 250 mg ephenidine at around 30-50 mg and never had any chest/heart sensations that made me worry.

I think this class of compounds is worthwhile from the perspective of being altered, contemplation, a bit of internal insight/CEV ETC…..but none of my experiences suggests to me taking it above 100 mg at most would be “responsible”

I had 3 solid years of lower dose MXE use and it was “functional” as I think a disso could be, last weekend my 50 mg ephenidine experience brought me within range of some of the interesting type of though processes and positive insights MXE provided as a lower dose experience

I just lost my dog of 16 years….and have a host of convening work/financial/jury duty stressors ,having NMDA antagonists around for helping my mood has been pretty damn nice the last 20 years.

 

[Asante]

I just lost my dog of 16 years….and have a host of convening work/financial/jury duty stressors ,having NMDA antagonists around for helping my mood has been pretty damn nice the last 20 years.

Sorry about your dog *hugs*. I recently completed a 5 year ordeal of extreme agony, rotting wounds and failing antibiotics. Doctors threw opioids at that like it was the end of the road for me (God said I would live so I went with that) but NMDA antagonists were much more effective in dissociating me away from the pain than the painkilling morphine, fentanyl, buprenorphine and oxycodone provided, so i selfmedicated NMDA antasgonists and avoided opioid addiction, which is one of the worst addictions to get rid of.

 

[idle_curiosity]

While there have been deaths recorded associated with the use of diphenidine and methoxyphenidine, there are no reported deaths associated with ephenidine [*] (which isopropylphenidine would be presumably more similar to...). Personally, I love ephenidine and will now keep my eyes peeled for its sibling, which from the small number of reports I've read, sounds pretty awesome.


[*] Corkery JM, Copeland C, Schifano F. Deaths related to the use of diarylethylamines, with a focus on the United Kingdom: A systematic review and case series report. J Psychopharmacol. 2025 Jul 1:2698811251349203. doi: 10.1177/02698811251349203. Epub ahead of print. PMID: 40590233.