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Any experiences with potentiating mushrooms with TCAs?

A

Ayrios

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Mar 3, 2002
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It's pretty well accepted that tricyclic antidepressants should potentiate the effects of many hallucinogens, like LSD or mushrooms. However, I haven't been able to find any specific examples. Has anyone on a regular TCA regimen (I'm assuming a single dose of a TCA prior to dosing would do very little, if anything) experienced mushrooms and noticed any degree of potentiation? How would you explain the effect? Did the experience last longer, or did it just seem like you took a higher dose of mushrooms (which could also result in a longer experience)? I take 100 mg of nortriptyline daily as a migraine preventive, and will hopefully be able to answer this question sometime soon. I'm on a rather small dose, so I don't know how dramatic the effect will be.
 
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I thought I'd post an update on this, just for the record in case someone later was to search "TCA and mushrooms" and only see my question. Unlike with alcohol and opioids, I noticed no potentiation or difference of any sort after ingesting 3g of cubensis. Oh well.
 
that would make sense as TCAs effect Norphephrine and Shrooms are mostly working on Seritonin.. Honestly, if anything since TCAs have a minor SSRI effect i would think they would inhibit the trip a little... but thats just my thought -- but I mean strong SSRIs are typically used to abort trips from tryptamines.
 
TantricBuddha, yeah, that seems to make sense, but I was basing the possibility primarily on fairnymph's big interactions thread which says TCAs could potentiate tryptamines. Nortriptyline is one of the TCAs that doesn't have an SRI effect, though. It seemed to have no effect at all on the experience, but 3g is a strange dose for me (availability concerns at the time) and I usually take closer to 4g. One sample is hardly adequate to determine this, so if I notice anything different next time, I'll report back

B9, do you know specifically what TCA this was and the dose? I won't replicate it, but I'd be interested in the type as different TCAs act on different NTs.
 
^ I think B9 might have been on about me & I'm on 210mg of lofepramine (Gamanil) a day. It's almost exclusively noradrenergic in activity (with a small degree of dopamine reuptake inhibition) and if you consider that amphetamine is noradrenergic/dopaminergic, with almost no serotonic action, yet noticably potentiates LSD, psilocybin etc, it's not a great leap to think that TCAs would potentuate the same drugs.
 
I'm surprised no one in this thread has mentioned the reports of LSD being a bad, and according to one report, lethal, combination with tricyclic antidepressants (esp. lithium). I wouldn't fuck around with combining them with anything as similar to LSD as psilocin. It's weird since LSD usually has such a high therapeutic index. It must alter brain chemistry in some way that makes one susceptible to TCA overdose or something (think it happens through serotonin syndrome). I'm sure people have mixed with LSD and had a fine time of it, too, but maybe your physiology is like that of those who weren't fine -- you feeling lucky? If you ever get off the TCAs and still want to use psychedelics make sure you wait a while so they leave your system first.

Lithium or tricyclics (like Amitriptyline, Anafranil, Asendin, Aventyl, Elavil, Endep, Norfranil, Norpramin, Pamelor, Sinequan, Surmontil, Tipramine, Tofranil, Vivactil) are fairly consistently reported as being very bad in combination with LSD. People attempting this combination are unable to communicate with others, they go into "fugue states" where they end up in other places and don't know how they got there, and they are generally in a terrible place psychologically. Life-threatening seizures and at least one DEATH have been reported to be triggered by the combination of LSD and lithium. Source
Click to expand...
References at bottom of linked page.
 
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At the beginning of the week I was certain on taking shrooms but now people are talking about death and all kinds of nasty things. What do I do?
 
I did do 2ci about a year ago and didn't feel anything, but I'm not sure what it does to the brain vs. Shrooms or others.
 
I've been smoking the nasty and ugly meth every weekend for the last few months. Do you feel that it would be safe b/c I have done E and used to do Psychadelics b4 I was on SSRIs and TCAs?
 
Ecstasy is nowhere near as similar to LSD as the psilocin in shrooms is. We don’t know everything about how psychedelics work in the brain, nor about how different types interact with TCAs (maybe the 2C-I experience is relevant, maybe not), nor how about they work with your individual brain chemistry. We just know there's evidence that they're sometimes extremely bad to combine with LSD.

What do you do about your lack of certainty after hearing about this potentially deadly interaction? You be uncertain and maybe risk death if you want to go through with it, plus start off your trip thinking maybe it’s the start of horrific suffering and your really stupid unintential suicide. That or you quit TCAs for a month before you do it. Sorry, but there's no more reassuring answers that can be given honestly no matter how many questions you ask trying to get them. Even someone posting they've done the combo without issue wouldn't mean anything, as others have done TCAs with LSD and been fine, yet there's substantial evidence that others haven't. You can't know. Also, there’s an edit button if you need to add stuff to your post (instead of making a new post every few minutes). This isn’t a chat forum so you don’t have to worry about the thread dropping off the page super quick.
 
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While I understand where you are coming from and I think I will wait on the trippin. At least till I get off these horrific meds.
 
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