4DQSAR
Bluelighter
- Joined
- Feb 3, 2025
- Messages
- 5,438
I ask because I noted that in the few reports I read, the first 4 hours were good, the next 8 were bad. That is almost certainly because sequential N-demethylation makes the metabolites less MOP selctive. In essence, those metabolites are KOP ligands i.e. dysphoric.
It's such a potenc compound that it's impossible to send a 'mystery powder' to the end user. I don't know if it even COULD be made safe. I'm purely interested in learning how the subjective effects change over time. I also have to wonder if C-8813 has been misrepresented as BDPC. Because swapping that phenylethyl 'tail' for a 2-(2-thienyl)ethyl tail yields a slightly more potent compound... and let's face it, these days vendors ONLY care about potency.
But that tail in C-8813 also makes the compound less selective so yep, stronger but nope, no fun.
Has anyone else noticed that that same 2-(2-thienyl)ethyl tail is well represented in fentanyl homologues yet I know of only a single case where a similar compound turned up in Russia. It was beta hydroxy thiofentanyl and that hydroxyl not only increases potency by an order of magnitude, it does so by increasing MOP affinity. I say ONE because a coroner's report said that some unlucky user in St. Petersburg mistakenly though it would be ABOUT as potent as fentanyl... not ten times stronger.
Where would you draw the line? produce 0.1mg tablets (with a break-line)? Because shooting pills is BAD, but psychology takes a part. 99% of all medications come with the instructions to take one or two pills, so psychologically, user would FEEL that more than two was an overdose. But this is academic. It's just too damned dangerous!
Yet we may still learn from 'trip reports' if only to first-responders might be able to spot when it's BDPC (or homologue) and save lives.
It's such a potenc compound that it's impossible to send a 'mystery powder' to the end user. I don't know if it even COULD be made safe. I'm purely interested in learning how the subjective effects change over time. I also have to wonder if C-8813 has been misrepresented as BDPC. Because swapping that phenylethyl 'tail' for a 2-(2-thienyl)ethyl tail yields a slightly more potent compound... and let's face it, these days vendors ONLY care about potency.
But that tail in C-8813 also makes the compound less selective so yep, stronger but nope, no fun.
Has anyone else noticed that that same 2-(2-thienyl)ethyl tail is well represented in fentanyl homologues yet I know of only a single case where a similar compound turned up in Russia. It was beta hydroxy thiofentanyl and that hydroxyl not only increases potency by an order of magnitude, it does so by increasing MOP affinity. I say ONE because a coroner's report said that some unlucky user in St. Petersburg mistakenly though it would be ABOUT as potent as fentanyl... not ten times stronger.
Where would you draw the line? produce 0.1mg tablets (with a break-line)? Because shooting pills is BAD, but psychology takes a part. 99% of all medications come with the instructions to take one or two pills, so psychologically, user would FEEL that more than two was an overdose. But this is academic. It's just too damned dangerous!
Yet we may still learn from 'trip reports' if only to first-responders might be able to spot when it's BDPC (or homologue) and save lives.
