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Psychedelics Antipsychotics and mushrooms

simmmone

Greenlighter
Joined
Jun 24, 2026
Messages
3
So it's mushroom season here in Aus atm and I've wanted to give them another go. However, I'm on Quetiapine 100mg and know that's it's probably unsafe for me to take mushrooms while on my medication. Has anyone got any advice on how I could wean myself off to prepare for my trip or any other risk management advice? Should I ask my psychiatrist? I'm worried I'll face judgement or consequences for asking. TIA
 
i take mushrooms on antipsychotics. i take olanzapine. more important than antipsychotics mean no mushrooms ever. which is an institutional perspective held by psychiatrists and psychologists is the question of the safety of thendrug interaction. a quick google search clears that up. but more important is the question, does my current psychological state invite the intense reality destabilization associated with my target psychedelic and do i have the peripheral support, institutional specialists ironically, if things go awry.

i would never tell a shrink or a therapist about my intent to use psychedelics but i sure as hell would tell them ive had a fundamentally destabilizing event and am in an active psychosis if it came to that after a psychedelic trip.

avoid pseudo sciency conspiratorial nonsense going into the trip. stay focused on personal growth and learning. recognize that if youre determined to trip, then youre probably gonna. ensure you have the peripheral support.

a trip sitter who knows youre going to trip and maybe is with you during the trip depending on comfort but i think checking in is fine if youre comfy.

a therapist appojntment set up for the week after the trip.

your psychiatrists phone number if you end up having a crisis event.

a recognition that your trip sitter has permission to call emergency services and that you appreciate them doing so in advance. no resentments or ruined friendships here. theyre doing you a favor.

a recogntion that what you learn or experience will
likely make sense to no one but yourself and that your transformative experience doesnt need to resonate with anyone but yourself.

trip killers, xanax is the best one, on hand, either in your or your trip sitters posession, with special permission tonyour trip sitter to forcibly dose if necessary.

and a good vibes set and setting attitude to make it as pleasant as possible.

drug interaction awareness. for me olanzapine taking person. requires me to go three days without medicine in order to roll ecstasy. so im already in a vulnerable psychological state going into the experience. ive got to be very careful when i roll. very very careful.

find our about the drug interactions. follow the advice above. andnyou should be gucci and good to go.
 
My biggest concern is serotonin syndrome. That seems to be the biggest risk factor for taking mushrooms while on Quetiapine. If tapering myself off Quetiapine before a trip will reduce the risk of serotonin syndrome then I'm willing to do it and then slowly put myself back on my regular dose and go about life as normal. But I don't know what the actual likelyhood of serotonin syndrome is or if that's just something they tell everyone
 
Sounds like you’re invested in your health, that’s a good thing. Society and the world in general are taking a second look at psychedelics for mental health support. I suggest do what you are doing in preparation for the event, however, even if by chance you don’t have a full experience tripping, which has been my experience, mushrooms or whatever your choice of substance may be, your brain will benefit from the experience.
 
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