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Misc Anti-Depressants that have worked for you?

Zyban worked pretty good for me one time. It's one of the few that works on Dopamine.

I believe the problem with ssri's and snri's is that depression is more of a dopamine issue than it is a serotonin or noradrenaline problem.
I've tried most of the modern antidepressants over the years.

I had been told by doctors for years that been Mirtazapine would probably be the best for me. I thought they didn't know what they were on about because when I did try it it made me so drowsy and hungry and not much else.

It was untill many years later when I read that it was being trialled for meth withdrawal. At the time I was a bad meth junkie trying to get clean. I gave it ago and it really did help at very small doses.

I must note for meth withdrawal it won't work any where near as effectively if you are taking it regularly. It works well if you implement it as a new addition at the same time as dropping the meth.

So after staying on it for awhile and getting past the extreme tiredness and hunger as well as staying off meth. What do you know? The doctors were right. It's definately the best one for me out of the many many I've tried. Even when going through done of the worst circumstances of my life my depression was the best it's ever been. It helps my cope with stuff alot better, keeps me calmer and helps with my insomnia. I've also been off meth for 8months and I believe it's largely by cause of the Mirtazapine I haven't felt like death the last 8months.

I was on 45mg a day for a long time but dropped down to 30mg be use I'm now on the Suboxone program as well.

I hope my long-winded story helps someone out there
 
this may be a bit off topic, because all of them are plants or supplements but:
kratom, kanna (not enough long lasting), Polygala extract, Calamus, HBWR has a very strong afterglow, Huperzine A, Yohimbe it's pretty antidepressant but not suited for daily dose, and one odd plant that people don't know so much but it's amazing: Sutherlandia Frutescens.
 
garygroundwork said:
I'm interested in stories about Anti-Depressant medications that have 'saved' your life or improved the quality of your life.

Recently a work colleague of mine was in a dark place. Fucked, depressed. Couldn't get out of bed for weeks, couldn't eat, sleep, crying all the time etc... real bad

After 2 or 3 months on Zoloft working up to 100mg a day he is a completely new person. The change has been nothing short of remarkable.
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Sertraline/Zoloft made a huge improvement for me. Still working 16 years later.
 
This post is specifically about SSRI-type drugs that broadly increase serotonin. This contrasts drugs like mirtazapine/cyproheptadine/amphetamine that reduce serotonin's effects (either directly or indirectly by boosting dopamine).

To provide some contrast PLEASE BE CAREFUL before using SSRI drugs.
At least learn about the common side effects so you can make an informed choice.

On the SSRI fluoxetine (Prozac) causing depression:
Three years before Prozac received approval by the US Food and Drug Administration in late 1987, the German BGA, that country's FDA equivalent, had such serious reservations about Prozac's safety that it refused to approve the antidepressant based on Lilly's studies showing that previously nonsuicidal patients who took the drug had a fivefold higher rate of suicides and suicide attempts than those on older antidepressants, and a threefold higher rate than those taking placebos.
Using figures on Prozac both from Lilly and independent research, however, Dr. David Healy, an expert on the brain's serotonin system and director of the North Wales Department of Psychological Medicine at the University of Wales, estimated that "probably 50,000 people have committed suicide on Prozac since its launch, over and above the number who would have done so if left untreated.
...
Now a decade later, Lilly has targeted Dr. Joseph Glenmullen, whose book "Prozac Backlash" has apparently incensed Lilly executives.
Dr. Joseph Glenmullen, a clinical instructor in psychiatry at Harvard Medical School and a clinician at the Harvard University Health Services, says he wrote the book because he was alarmed by the number of patients who were reporting severe side effects from the serotonin-boosting antidepressants including Prozac, Paxil, Zoloft, and Luvox. "The two most upsetting side effects were patients becoming suicidal on the drugs, and the development of disfiguring facial tics," he said in an interview.

The Boston Globe, 2000.
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Damo_40 said:
I believe the problem with ssri's and snri's is that depression is more of a dopamine issue than it is a serotonin or noradrenaline problem.
I've tried most of the modern antidepressants over the years.
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You're on the right track. You might enjoy reading this article on serotonin's role and the advent of SSRI drugs.
 
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Best - rapid acting antidepressants:

Ritalin (Methylphenidate) - New mild stimulant & Antidepressants, Ritalin renews zest for living with mood-boosting properties. A safer alternative to Amphetamines as Ritalin in most cases doesn’t affect appetite or interfere with sleep, and has little to affect of HR & BP

Ketamine (Esketamine nasal spray) - a rapid acting antidepressant. Used offlabel (now officially) for treatment resistant depression and severe anxiety in addition to pain relief. Potentates opioid analgesics. Increasing dopamine & NMDA antagonist Ketamine has significant mood-boosting properties taking effect in minutes

Depo-Testosterone 200mg IM injection (Men only) - a robust antidepressant with significant mood-boosting properties. Reaches peak serum levels 1 to 1.5 days after administration. One feels happier, more confident & social, enhancing mental cognition and physical strength, enhanced vigilance and endurance, heightened sexual desire and enhanced performance, erection frequency and firmness. Free-T levels back to baseline in 2 weeks.

Bupropion (Wellbutrin) 150XR / 300-450mg XR tablets - a moderate antidepressant & DNRI - nicotinic receptor antagonist used in smoking cessation. A beta-ketone-amphetamine analog, Bupropion acts as a mild stimulant by increasing dopamine & norepinephrine in CNS (dopamine weakly. Does not inhibit more than 50% of DAT - which is required to induce euphoria)

Ultimate natural safe antidepressant- Daily moderate cardiovascular/arobic exercise (releasing endorphines & Phenylethylamine metabolites - which is the bodies natural Amphetamines & Opioids, responsible for the “runners high” and robust mood-boosting properties

Healthy diet + arobic exercise/active lifestyle + social (friends & family) = A+ mental & emotional health, physical fitness, diet and healthy social life……the ultimate Antidepressant.

The above pharmaceuticals should be supplemented in lowest possible therapeutic dose to provide lift while minimizing negative effects such as dependency & tolerance / addiction or abuse. Best not to be dependent on SSRI or other substances, when naturally healthy options are available

Ketamine is a “rescue med” for RAPID effects when needed - severe panic attack, deep dark depression, Ketamine works in minutes if not seconds, inducing rapid robust euphoric calmness and anxiolytic effects. Significant dopamine release in brains reward centre in proper therapeutic doses. Too much will act as disassociate anesthetic and subject will be “tranquilized” in “K-Hole” unable to move for 10-30min, while not effecting breathing or HR/BP (safe)

Ritalin 5/10/20mg increases/increases dopamine 3-4X greater than norepinephrine in CNS and at normal therapeutic doses DOES inhibit more than 50% of DAT …..which frequently causes pleasant euphoric mood-boosting effects in subjects (ED-50 - 0.25mg of HCL salts / per Kg of body weight) Ritalin 20-40mg IR will inhibit 60-70% of dopamine transports …..enabling dopamine & norepinephrine to accumulate / increase in brains reward centre & executive function.

If I new someone in dire straits with severe depression I would give them: adult male

Testosterone 150mg IM (would take effects 2 days after tapering off in 1.5 weeks)
Ritalin 10mg + 10mg 2.5h later
Oxy-IR 5mg
Alprazolam 1mg
Diazepam 10mg
Pregabalin 150mg
Ketamine (minimum effective low dose)

All in one glass (minus Test & Ket) the subjects anxiety & depression would melt away in 45min reaching peak serum levels in 1.5h …..they’d be emotionally & mentally uplifted in a stress/anxiety free state with a much needed moderate euphoria, happy and sociable it would be a breath of fresh air under the warm sun 🌞….a spray of Ketamine in each nostril would enhance the mood-boosting effects even further. The Oxycodone is a non-sedating significantly euphoric opioid which would compliment the dopaminergic stimulant - Ritalin (Methylphenidate) 10mg and Alprazolam (Xanax) + Diazepam (Valium) potent anxiolytic & antidepressant. Pregabalin (Lyrica) another effective anxiolytic & anticonvulsant with mood-boosting properties. All doses & compounds are low therapeutic doses for a naive adult male, when combined in an oral cocktail the work in a synergistic manner, potentiating each other, as well as balancing the effects, hence the stimulant with opioid + benzodiazepine etc. A 200lbs healthy man could easily tolerate these compounds at their lowest starting doses …..when ready to “jump off a cliff” sort of speak.

This scenario is a “rescue med” situation for certain individuals with suicidal ideation & severe depression

This entire cocktail should be marketed in an auto-inject pen for SC injection into thigh, in a safe, sealed & contained auto-inject pen kept on person for immediate administration if required for emergency situations…..THATS a cool kit to have I’m my opinion :)
 
Dextro .45 said:
Testosterone 150mg IM (would take effects 2 days after tapering off in 1.5 weeks)
Ritalin 10mg + 10mg 2.5h later
Oxy-IR 5mg
Alprazolam 1mg
Diazepam 10mg
Pregabalin 150mg
Ketamine (minimum effective low dose)


This entire cocktail should be marketed in an auto-inject pen for SC injection into thigh, in a safe, sealed & contained auto-inject pen kept on person for immediate administration if required for emergency situations…..THATS a cool kit to have I’m my opinion :)
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Seems like an amazing cocktail

Problem is ... it is so hard to access these substances
 
I tried many meds labeled asi an antidepressants and also other meds labeled as cure for something else but from everything i experimented with i have to mention

1, Vortioxetine 20mg daily, unpleasant for first few weeks but now i take it for years and it absolutely lifts my mood, help with pain and improved congnitive performance because it makes your dopamine, acetylcholine, sorotonine, noradrenaline raise. It doesn't inhibit enzymes and half-life of +- 60 hours Is nice too.

2, Mirtazapine - this one Is interesting because when i take it before sleep i sleep whole night but at morning i definitely feel that it boosted my motivation probably by noradrenaline related mechanism

3, Modafinil - It's more as needed than daily thing but for me it's very uplifting and slightly euphoric because it makes music more satysfiing and boring tasks are not boring. Only negative is that falling asleep is more difficult

4, Opioids but especially Tramadol - gives me energy, positive mindset, help with all kinds of pain. It's low affinity opioid but other effects that it has turn it into almost speedy, happy and potent antidepressive painkiller.

5, Tramadol + valium= Tramalium, superanxiolytic mood boosting painkiller. Also much more relaxing and longer lasting than 6, tianeptine which is great antidepressant but i would compare it to the crack of opioid related antidepressants.

7, Dextrometorfan, citalopram and bupropion were also working but they lost effects after just a few months.

Right now i take vortioxetine, safe tramadol doses and modafinil and i can't be unhappy. It makes me completely free of depression. Valium and alprazolam are helping too but i consider them not antidepressants, just minor sedatives for relax with less worrying about life situations and to prevent possible overloading my brain with serotonine.
 
Ritalin (Methylphenidate) - VERY safe & euphoric dopaminergic stimulant

Benzedrine / Dexedrine / Methaedrine

Ketamine / MDMA / LSD & Psilocybin

Depo-Testosterone 200mg IM (AMAZIMG Antidepressant & mood-boosting compound)

Wellbutrin (Bupropion) DNRI

Oxy-IR 20mg (Oxycodone) Most euphoric Opioid easily

d-Desoxyephedrine HCL 20mg IV injection + Oxycodone 40mg IR + Xanax 1mg & Valium 10mg + Pregabalin 300mg = Amazing Antidepressant
 
bvc said:
did you notice any side effects with either?
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they are on my mt rushmore because of the small scale, of the side effect profile, to the extent that it is indiscernible.

ofc when you go on or off a med like these, faster than intended, it can have more deleterious effects in the short term.
 
I know its not the answer you're looking for, but tryptamines (psilocybin, DMT, so on) have been fairly reliable as antidepressants for me without the significant side effects I get from things like SSRIs.
 
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