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  • BDD Moderators: Keif’ Richards

Anti-depressants... please help me

phatass

phatass

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Joined
Aug 4, 2007
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A glass bottle in the ocean between waves and rock
i'm tapering off benzos after 3 years of use, i'm at 50mg diazepam/day atm and slowly diminishing... but i am allready starting to worry that when i get off the benzos, the old GAD will come back severely... my doctor however insists that if i take an anti-depressant, it will take care of my anxiety, my insomnia and my depression...

she swears by "Maprotiline (sold as Deprilept, Ludiomil, Psymion) is a tetracyclic antidepressant (TeCA). It is a strong norepinephrine reuptake inhibitor with only weak effects on serotonin and dopamine reuptake."

I am wondering if anyone has tried this AD... the effects, good and bad...

she also refuses to Rx me Pregabalin (lyrica) for anxiety, because she doesn't know the compound....

also i presume i will not be able to take anymore MDMA... right?

any info is welcome... this is very important for me...

thanks
 
Hiyer Phatass :)

You've got some serious balls for going at your Benzo use mate, especially after so long.
I iz ded proud uv yoo blud ;) :) Really wish you the best.

As for that Tetracyclic, I was only aware of Mirtazapine being the only one, but it appears that's not the case as I've just checked and there's atleast 5 more.

Personally, I'd really love to try a different Tetracyclic - I tried Mirtazapine and felt suicidal from day one, but many, many other people swear by Mirtazapine being the best Antidep they've ever taken (which annoyed me).
So I think you'll be in good company with that med :) I don't know anything about it other than what Wiki says, but if it's as good as Mirtazapine is for other people then it should really help.

It's silly she won't script you Pregabalin. Should tell the bitch to do some fuckin revision :| lol
Maybe it'd be worth getting a Beta-blocker as well for some of the other symptoms which'll come with Benzo withdrawal?

As for using MDMA whilst on it, I don't think it'd be wise but we could have a check on the Antidepressants and Recreational Drugs thread....
There is a lot of controversy about rolling on bupropion. Some people (especially people who have bipolar) find that they can roll normally. Some people find that they roll slightly less hard than normally. Some people find that they only roll a little bit. In general, most people find that they can still roll, but not quite as hard, and so they often need to take more MDMA than usual. However, until you know how MDMA affects you personally while you are on bupropion, take your normal dose of MDMA. If you are at all prone to seizures, you should avoid combining bupropion and MDMA as you are more likely to suffer a seizure with this combination.
Click to expand...

Food for thought :)
 
thx for the input.....^^so is buproprion a SNRI with little effect on serotonin like Maprotiline...

as for mirtazepine i gained like 25kg in 2 months... i've just started to lose weight (11kg in 2 months) so the last thing i want to do is go on mirtazepine... Maprotiline apparantly makes you gain approx 2 to 4kg
 
I've never even heard of Maprotiline. Did you mean Remeron? If so, I think it's usually better to compliment an ssri. If it (whatever drug you are speaking of) has a high norepinephrine reuptake, I found that those drugs make me even more anxious. For instance, Effexor and Pristiq made me very anxious.

I suffer from GAD and panic disorder and have taken: Prozac, Zoloft, Effexor, Paxil, Lexapro, Pristiq, Wellbutrin (those are only the ssri's/snri's). Out of all of them, I am content with Paxil. For me, it calms me and I'm no longer a constant worrier. I also take 1mg clonazepam twice a day and 75mg of seroquel twice a day. I am thinking of stopping the seroquel (I only recently started taking it).

But yes, it would be wise to start an anti-depressant...although I don't agree with your dr's choice. But then again, everyone's body is different and what works for one, won't work for another. I would HIGHLY suggest starting on an SSRI.

Regarding MDMA, I've rolled many times while on an ssri and although it makes the substance weaker, you can still roll your face off. :)
 
No...that is not true. Without an anti-depressant, I'd be a constant nervous wreck. I am also in therapy, which helps while taking an anti-depressant.
 
First of all, if your doctor insists that taking an Anti-Depressant will "cure" your anxiety problems, then quite frankly he's full of shit. It definitely is true that Anti-Depressants are quite frequently very effective in treating anxiety. But no doctor should ever give their patient any sort of "guarantee" that a certain medication or type of medication will successfully treat any problem, & considering how the statistics on the success rate of Anti-Depressants are all over the place & therefore inconclusive by nature, your doctor really, REALLY shouldn't guarantee that an Anti-Depressant will successfully treat your anxiety.
I've never even heard of the medication your doctor wants to put you on, & I've never heard of anybody who's taken it either. & I've been prescribed a lot of different types of meds for Depression in my lifetime, as well as a lot for anxiety.
Why your doctor wants you on that medication, I really don't know. SSRIs -- medications like Zoloft, Prozac, & Lexapro, that effect your Serotonin levels only -- are thought to be the most effective Anti-Depressants for treating anxiety.
Also, according to my current psychiatrist, while Anti-Depressants that only increase Serotonin levels are often effective at treating anxiety, Anti-Depressants that focus on increasing Norepinephrine (sp?) levels not only aren't helpful for treating anxiety, but can make anxiety worse. My doctor explained to me the science behind it, but all I remember is that because of certain things about the differences in how Serotonin effects your brain & how Norepinephrine & Dopamine [Norepenephrine in your brain is "converted into" Dopamine, to put it in very simple terms], SNRIs (Serotonin-Norepenephrine Reuptake Inhibitors) ideally should only be prescribed for Depression when anxiety isn't present, or when other types of Anti-Depressants have been tried & found unsuccessful. I haven't heard anything about TeCAs in particular from any doctor -- I'm pretty sure those are really "old-school" meds -- but I know they effect Norepeneprhine [why do I even bother trying to spell that?] levels more intensely than SNRIs.
I have extreme anxiety problems & I've had absolutely horrible reactions to Anti-Depressants that effect Norepinephrine levels. However, my mom was recently prescribed Cymbalta (an SNRI) for her Depression & Anxiety problems, & she swears it helps her anxiety issues a lot, so obviously there are exceptions.

I'm not telling you to tell your doctor that you don't want to try the medications he suggests because of what I or anybody else on an internet forum said; I'm just saying there are definitely some questions you might want to raise with him about why he wants you on that medication.

&, considering how little TeCAs effect Serotonin levels, you actually still will be able to do MDMA. It will effect you a bit less, but it won't decrease the potency to the point where taking it is just pointless.
 
Congrats on the taper stay strong, and make sure ur doc maintains u if you withdrawal. Benzo w/d can b serious and even fatal. As far an SSRI/SNRI as previous poster stated it made me very anxious too. It had a strong caffeine like effect on me jittery and anxious. Most doctors push antidepressants as a cure all for everything because there considered safe and non addictive. Even tho when ur on them u will w/d from em n it's far worse than most w/d from other substances. The antidepressant companys push em on the docs with gifts n $ n w/e. They rather give u a snri than a benzo any day of the week but it's all too obvious a benzo is way more effective. It's like giving ibprofen instead of vicodin for a compound fracture. Just to avoid liability and lawsuits over o/d or abuse issues. As far as MDMA use I kno u can use while on snri's but has different effects on different people. But MDMA of course will worsen your GAD and depression and possibly send u back to square 1. Good luck hope I helped! Stay strong bro. And as always this is all derived from personal experience.
 
An anti-depressant may take care of all those things, or it might not. No grantees for anyone, we don't even know exactly why they help in the first place, they just do for some people, but not for others.

isnt it true that there is no evidence that antidepressants perform better than placebo?
Click to expand...
There is plenty of evidence to suggest they are better than a placebo, otherwise the DFA wouldn't allow it. Problem is, there is also evidence to suggest that it's the same as a placebo. Depends on the study. Certain ones work for some people, but different ones may not work in the same person. There is also treatment resistant depression, which doesn't respond to anti-depressants.

Looking at what Maprotiline binds to, you may still be able to roll, but it may not effect you as much. Not like SSRIs anyway.

I haven't tried that particular one, but I just got prescribed lovan (what they call prozac here) for my social anxiety, and it seems to be pretty good. I was hoping for some kind of benzo (I know those definitely help me lol), but if the SSRI actually works, it's better. Your doc prolly swears by it because she's seen it help a few of her patients (or she's being influenced by the pharma company's marketing or something :P)
 
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