Anti-cholinergic effects with a-typical AP - olanzapine?

[JohnBoy2000]

They have a tight binding affinity - specifically olanzapine - with the mACH receptors, and text articles mention it as a potent anti-cholinergic.

Personally, I didn't notice any anti-cholinergic effects with it: urinary retention, dry mouth etc.
Not even sedation.

I was up on 15 - 20 mg.

Slight initial sedation at about 20mg due to its antihistamine action, but that would fade after a couple of hours.

Is it considered a potent anti-cholinergic on a par with say, early tricyclics - amitriptyline etc?

I also didn't experience any weight gain on olanzapine - nor appetite increases, not even for sugars.
Though I do get this with mirtazapine - and it's most welcome.

AP's claimed primary mode of action is D2 antagonism - and that incites sedation?

I'm curious as to why D agonism with say, anti-parkisons agents, is also sedating.

And then dopamine reuptake inhibition is stimulating - with amphetamines and some DNRI's etc?

Baffling....

 

[Cotcha Yankinov]

I'm surprised you didn't get anticholinergic effects, but if you look at the affinity for M1 compared to 5-HT2A and D2, the latter are much higher, and are going to effectively place a cap on how strong the anticholinergic effects are going to be (before extra pyramidal symptoms appear).

But the pharmacokinetics could have been weird, it's possible some people may be achieving different CNS concentrations of various drugs.

 

[d1nach]

Im getting affinities of 6 - 12 nm for this vs 6 nm for benadyrl at muscarinic receptors. So at 20 mg Its quite possible you didnt notice anything.

Drugs like amphetamine and benadyrl are stimulating to the heart because they increase singaling of cAMP via Gs activation of gcprs family which cause complex stuff basically speeds stuff up litterly. Its really confusing and I dont really get it lol

Amphetamine alcohol and morphine could be consideried stimulating in that they activate the reward pathways

Amphetamime and strattera could be considered stimulating because they jack up your norepinephrine making you feel like a your alert

 

[Cotcha Yankinov]

D2 agonism specifically could be activating homeostatic autoreceptors that decrease dopamine release, but those autoreceptors may not be present in Parkinson's patients whose presynaptic cells could have degenerated.