I always inwardly cringe when some novel molecule with a name similar to a previously awesome And successful RC(usually too successful as it was quickly added to the global list of schedule I substances.). This series of chemicals was explored extensively with the U-47700 being the crem du le crem. About twice as potent as good ol' Diamorphine and lasting about half as long, it also bathed human receptors in histamines, but otherwise could pass for heroin IV despite its vastly different molecular structure. It took me a year of "experiments" to realize the shit smoked like ice but with a heroin rush. It could have become the opioid version of crack if some one at the DEA hadn't realized the danger before the RC exploiters discovered this fact and flooded the high schools with it. Wew, I never thought I would give props to the DEA, but man that was close.
Now back to U-48800. The almost ubiquitous error chemical adventures make is presume that because a molecule is a close homologue or analogue of substance X, that X+Y will be a similar substance. These people talk about structure activity relations with an apple doesn't fall far from the tree conviction.
Let me disabuse you of this nonsense with a simple example.
Take DXM, yes the crap in much cough syrup. If you take the exact same molecule from a chemist perspective the dextro isomer is to the levo isomer the same. Same exact amount of atoms make up both molecules, all the atoms are almost in the same position to one another.
The only difference is one of the bond angles. This makes the polarized light shown through a vapor of one pure enantiomer rotate to the clockwise in one and counterclockwise in the other. A chemist would probably say the two enantiomers and the racemate were all the same.
From a pharmicologist perspective, the racemate would add powerful mu agonism to it's properties, and the pure LXM is a very powerful(stronger than heroin by weight. Not the mild Nmda antagonist so any bored children know.
My point is if just a single bond angle change can lead to vastly different biological activity, do you really think the close structure theory holds water for long? The lazy bastards in Congress who never saw a analogue act they understood; more poor troublemakers behind bars, and jobs for the US's most uneducated and unable to handle the hard pace of fast food or hard work of unskilled labor; a high school diploma and and a narrow mind are that's needed for a carreer in US penal industry.
Dumb ass constituents often drink on the job as alcoholics are often bragging about how they never even tried the devils weed let alone "bath salts" a term about specific as saying youth crime.
Anyway don't be as dumb as the bugs that write the laws that technically make every human being on earth a criminal guilty of the manufacture and transport of a schedule I. controlled substance(DMT and GHB are endogenous ligands, made in every human brain on earth so stop making drugs and transporting them or face the consequences. One can only wonder if these paragons of ignorance will arrest are incarcerate themselves when they realize that they are breaking at least two felonies every day thanks to their lack of research and just terrible judgement.