I usually feel pretty shitty when I do this (directly related to how much I AD I needed to stay up all night and the next day). Once, I was up all night on 100mg and couldn't get to sleep so I had a topper of 40mg around 8 or 9 am, and I stayed awake till the following night. But starting with that last 40mg dose, my heartrate was over 100bpm and stayed that way for the rest of the day, my head was pounding, and some general cracked out effects like the day after you take MDMA. It's probably worth mentioning that I was taking AD all week long prior to that all nighter and not getting much sleep or food. The effects seem to be more bearable if you don't abuse AD on a daily basis.
Also keep in mind that having such a large tolerance to the euphoria doesn't mean you have a tolerance to the neurotoxic effects. I would say that once you get into the hundred's of mg in a binge, it could be a possibility.