N&PD Moderators: Skorpio
Analogues of Fencamfamine?
dean stark
Greenlighter
Does anyone with better journal access than me know if any Fencamfamine analogues have been synthesized and/or evaluated?
Anyone care to speculate on viable substitutions?
Hammilton
Bluelighter
I'd have to look through my collection, but yeah, many have. I'm certain that n-methyl and n,n-dimethyl have been tested, among many other alkyl substitutions. Not as positive, but still fairly sure, that n,n-dichloro among other halogeno and dihalogeno substitutions have been tested.
atara
Bluelighter
Not 3,4-dichloro? N,N-dichloro sounds toxic if not explosive.
dean stark
Greenlighter
If you get time to dig them out, I'd really appreciate a couple of good references... =)
fencamfamine
Bluelighter
The N-methyl was equipotent but the T1/2 was only 50% (still very large). I seem to remember than the N-propyl looked OK as well. The N.N dialkyls were less active. I can only suggest that they act as prodrugs. The primary amine is also pretty active and the least complex from a synthetic POV.
From the research the N-ethyl is optimal. It's certainly possible to make analogues but at the end of the day they are not likely to match the original. It seems a shame to alter what is almost perfection. I can confirm that this compound is better than 4MAR (formally my favourite stimulant) and blows the crude, nasty PEAs into the dust. Maybe amfonelic acid is good, but I'm not convinced of it's safety. At least fencamfamine was marketed widely enough so dangerous side-effects would likely be known.
fastandbulbous
Bluelight Crew
From personal experience the N-methyl seemed a bit more potent and not much shorter length of effects (i assume the figures quoted are from non-primate species, which can make a big difference eg PMA is almost equipotent with LSD in rats!)