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an interesting chemical that seems interesting beyond the usual drugs discussed here

asecin

asecin

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Apr 13, 2005
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i found this chemical;

http://en.wikipedia.org/wiki/Tetrahydrobiopterin

seems fucking interesting to me and i bet to anyone else who is beyond the usual redneck drug chemistry here.
now, im not a chemist myself and i have little knowledge, but i can understand few things and what was interesting to me was reading this part:
"essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-hydroxytryptamine, 5-HT), melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline), and is a cofactor for the production of nitric oxide (NO) by the nitric oxide synthases"

now, this sounds pretty fucking interesting no ?? never heard of this ever before ! but it seems like a chemical to take notes on.

Tetrahydrobiopterin, developed by BioMarin under the brand name Kuvan and approved by the United States (U.S.) Food and Drug Administration

hmm... i wonder if it can be fun to experiment with this one. very limited information on it, but few things i found seem to be related to some gene disorders. reading about it tho, sure seems it can be helpful for wide array of things, even perhaps get high on !:\
 
as far as I am aware other than in PKU sufferers there is no shortage of this co-factor in most people, therefore it is not going to offer much in the way of benefits.

then again small additinal amounts is probably not going to do much harm either.
 
I don't think there's going to be any benefit to supplementation, most people should be making their own biosynthetically. See also: biotin.

Just because something is a cofactor doesn't mean more of it = MORE SEROTONIN!!! even though as vecktor stated, supplementation with reasonable amounts shouldn't be a problem.
 
yeh. seems fun to try as supplement and see if it raises either serotonin or any of the other mentioned melatonin, dopamine, norepinephrine (noradrenaline), epinephrine (adrenaline).

too bad its such obscure supplement that you cannot buy with RX and i dont think most doctors even know it to prescribe :/

nevertheless, seems people have no interest in it except me so i guess i should just let this one go :(
 
If I may ask, what is your interest in this? Novel structure? Interesting mode of action? Getting high? Nootropic effects?

Unless you have a specific reason for discussion, it just seems like a pharmaceutical, but slightly more interesting in it's effects.
 
Sturnam said:
If I may ask, what is your interest in this? Novel structure? Interesting mode of action? Getting high? Nootropic effects?

Unless you have a specific reason for discussion, it just seems like a pharmaceutical, but slightly more interesting in it's effects.
Click to expand...


Novel structure? Interesting mode of action? Getting high? Nootropic effects?

all of it
i have a thing for obscure chemicals. i rly wanna explore em but those synthetic ones are really hard to get and experiment with. i need all kins of permissions and RX requirements and doctors who actually know them ! surprisingly i know more drugs than any doctor in the case. :\

anyway, main reason behind the thread was to find people like me interested in this one, or not, and share infos if any they possible gather OR if they dont care about it, i dont see reason to force anyone of course. :D
 
nevertheless, seems people have no interest in it except me so i guess i should just let this one go
Click to expand...

They gave a pretty thorough and solid explanation as to why this shouldn't do much for people with normal enzymatic function.

ebola
 
Usually cofactors are not the rate-limiting factor in enzymatic reactions. A good percentage of them are generated in vivo (or in the gut by bacteria) in the required proportions. Some have toxic effects at large doses. We call quite a few cofactors "vitamins".

There are lots of equations out there describing rate kinetics etc but the simple fact of the matter is that this naive attitude that more monoamines = better performance is flawed. There are many enzymes that perform reactions with cofactors like biopterin or folate and it would be a waste of time to figure out the hard math behind cofactor concentration and reaction speed to find out later your body restricts concentrations to a certain range via metabolism.

I would expect supplementation with the title compound to be no better than a diet rich in vitamins and minerals.
 
This doesn't sound "Fucking" interesting to me at all. Do you really understand the role this chemical plays and what it does?

The body of the average individual or even "drug-user" does not have any problems hydroxylating the aforementioned amino acids either. So I doubt supplementation would produce even the most subtle of differences...
 
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