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[AmT+MxE]

Pretty hefty doses ;) Sounds great though.
Tonight I'm gonna be at a rave from 21:00 to 08:00, I'm thinking of 30mg at 19:30 then a 15mg redose at 22:00, will be doing small bumps of mxe every ~1.5 hours. Should be good right? :D
 
I enjoyed the combo too(@15mg amt + 20-40mxe) a couple times, but it also felt like it lead to an elevated temperature and an uneasy "too much" feeling. I'd start low if anyone tries it.

replace mxe with dmt and you will like it even more though:D
 
This combination is a match made in heaven! The only problem is that mxe works so long, it´s not really an afterparty drug ´cause you have to plan ahead....
 
Started with 30mg aMT then 2.5 hours later 15mg more. From the 3 hour mark on I took like ~15mg bumps of MXE every 1.5 hours.
It never got overwhelming except for like 2 minutes at the peak. The rest was just perfectly smooth sailing, had great conversations, marvelled at all the lights and the music sounded amazing! :)
Next time I'll be taking a little more aMT, but the dose I took was already very enjoyable.

One thing I do have to say is I can see how people would have trouble incorporating the experience into a party. A friend of mine I was with who took a little less (he does seem to need less than I do generally to reach full effects) kind of got hung up in the trip. He couldn't 'let go' and so he ended up just asking questions the entire time.
It's a matter of letting go and 'flowing', even though at these doses it might be difficult to have a full-on trip, it still basically involves the same mindset as other, stronger psychedelics.
 
It's so interesting that aMT has popped up again in the UK scene. All of the older RC kids in the US who tried it back in the day when it was legal here are a lil' bit off kilter these days, and yet their eyes light up like XXX-mas trees when you say alpha-methyl...How is it no one is worried about the MAOI effect of aMT in combination? I'm really surprised there haven't been any ODs reported yet. Not that I want that to happen at all, but that's always been my biggest concern with tasting it.
 
✰hyperobjects✰;9548540 said:
It's so interesting that aMT has popped up again in the UK scene. All of the older RC kids in the US who tried it back in the day when it was legal here are a lil' bit off kilter these days, and yet their eyes light up like XXX-mas trees when you say alpha-methyl...How is it no one is worried about the MAOI effect of aMT in combination? I'm really surprised there haven't been any ODs reported yet. Not that I want that to happen at all, but that's always been my biggest concern with tasting it.
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I agree, it's weird. Due to the pharmacologies, you'd think this combination would be dangerous and feel toxic as fuck, but apparently it's a really clean high and people love it, feeling no ill effects. This combo is all over the MXE Combination Thread and the four Big and Dandy MXE threads, with people constantly praising it while scratching their heads as to why it doesn't make you sick.

Fortunately, :D, I have just come into possession of both these substances. I have a hard time finding a good starting dose for the combo, though. I have previous MXE experience, but I need to try aMT a few times alone, starting at 5 mg, to get a feel for it before I start combining.
 
Sorry for putting this thread up again whereas last reply was year and quater ago, but I think this two RCs are popular nowadays (athough MXE can´t be legaly obtained from a lot of countries in Europe now) and few to many people got an idea to mix them..
From my experience, It didn´t feel toxic as all. 2 psychonauts (me and friend of mine, let´s call him Y) tried combo of MXE and aMT yesterday night and enjoyed it.
I had about 40 mg of aMT (oral and plugged), also drank a poppy tea from 5 pods (usually dose of pods from my source is about 8-10 with no tolerance) about 3 hours before trip andc also smoked a few bowels of pot. Y had 50 mg of aMT oral. Each of us consumed about 100 mg of MXE nasally during the night. We also drank a ginger tea for avoiding nausea during aMT comeup.


The comeup of aMT was quite speedy, Y couldn´t slow down to music we were listening, but I enjoyed music a lot. Especialy songs from Oasis or R.E.M.. After about T+3h into aMT we both dosed about 20 mg of MXE. After about twenty minutes strong wave of empathy hit us and we were unusual openly talking about past. At about T+4:30 we again dosed almost the same line as before. We both were like on speedy and more euphoric MXE trip, so we decidet to give a little walk in the night. Coordination was impaired, especialy in terrain with the lights out (and we have lights turn off most of the time). Y wants to dicover the world around so much that we both walked around 5 km before we came back to our place. We also walk extremely slow with lot of brakes to talks and Y also by his worlds could´t think and walk at the same time in the beggining :D
At T+8 we both insulffated about 50-60 mg of MXE and I also smoked a lot of pot, when MXE hit after a half an hour, I started to be tired a lot, speedy aftereffects of aMT start to substitude behind effect of pot and poppy pod sleepy phase. MXE also knocked me out that time, which is unusual for his chemical.
We both managed to sleep and we both slep instantly after about T+9:30. Last experience with aMT I coudln´t slept for 12 hours afterwards, so I was quite surpised.
Woke up after about 4 hours still feeling something. No hangover yet.
Altogether it was very enjoyable experience, I don´t want to guide someone to do this combo cause it is maybye quite dangerous (although we don´t know a lot about MXE anti-deppresant effects and if they are dengerous if combine with weak maoi such as aMT), but I also regulary drinked Passionflora tea to 4th day before experiment, wich is weak maoi too and I don´t experienced any sing of serotonin syndrome (my temperature was mildly high like with every aMT trip), just nice and mellow experience.
Still, doesn´t beat MXE + poppy pod + pot combo alone for me, although it´s potentionaly dangerous too, because of possibility of respiratory depression.
 
MXE has SERT affinity (now finally proven!) and as such mixing it with other serotonergics can lead to serotonin syndrome, which can often be fatal.

Basically, as fun as you found the combination, it's a gamble and not worth it.

It's MXE that's the dangerous one in this combination, as aMT's MAOI action is overstated and in reality rather mild - but nonetheless, affecting serotonin and even being an incredibly mild MAOI in combination with MXE is a no go if you value your safety.

At low doses lots of people have gotten away with it, but people have also gotten away with taking low doses of PMA/PMMA - that doesn't mean it's safe, or that taking the same dose next time won't leave you in hospital or worse.

If you want to combine aMT with a dissociative, go for Ketamine, as its action on SERT is basically non-existent, and it is safe in combination with serotonin releasers :)
 
If aMT is a MAOI then please explain how I combined it with 500mg of MDAI (over 4 hours) and experienced a maximum heartrate of 88bpm and no noticeable elevation in body temperature. I can see it being a competitive MAOI by weight but it is no way an irreversible inhibitor and therefore poses no significant risk (though obviously still unsafe in overdose).
 
I took about 15mg aMT once with 35mg MXE. It was wonderful. It was a light trip but very fun. The aMT was potentiated.
 
cannibalsnail said:
If aMT is a MAOI then please explain how I combined it with 500mg of MDAI (over 4 hours) and experienced a maximum heartrate of 88bpm and no noticeable elevation in body temperature. I can see it being a competitive MAOI by weight but it is no way an irreversible inhibitor and therefore poses no significant risk (though obviously still unsafe in overdose).
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^ If that's directed at me if you read through my post you'll see I'm saying the danger is MXE not playing well with serotonin releasers, rather than being the aMT causing the problems.

Also, not being an irreversible inhibitor doesn't make an MAOI safe. The difference is that a reversible inhibitor lasts a few hours and you only need to avoid combinations during this time - while irreversible MAOIs are long-lasting and much more dangerous as a result.

In the case of aMT it's not whether it's reversible or irreversible that comes into play here (though it's reversible, of course) - it's the fact that in reality it does not seem to be much more of an MAOI than compounds like amphetamine which in general do not have enough MAOI action to be considered an MAOI in the first place.

That said, as far as I'm aware we don't have any solid evidence saying that it is this weak of an MAOI - but for the most part, the fact that aMT seems to play well with other serotonin releasers until massive doses that would be outright considered an overdose anyway, suggests it doesn't have any significant MAOI action.

In general I'd advise caution if you do go ahead combining it with other serotonin releasers though.

That said, back to the combination at hand - simply put, combining MXE and aMT could lead to serotonin syndrome. Stick to a dissociative without SERT affinity like Ketamine if you want to try out a similar combination.
 
Jesusgreen said:
MXE has SERT affinity (now finally proven!) and as such mixing it with other serotonergics can lead to serotonin syndrome, which can often be fatal.

Basically, as fun as you found the combination, it's a gamble and not worth it.
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I don't think we can really say this. In the same way that SSRIs block the effects of MDMA instead of causing dangerous release, MXE should do the the same to the SRA effects of aMT.

Even if the combination of SRI and SRA could cause SS, this ought not to be a problem for MXE as its SERT affinity is not too high.

In moderation I do not think there is any reason to worry, but caution should be exercised.
 
i have experienced this combo once, at low dosages for both chemicals, with the mxe added at the tail end of the trip. there were no worrying symptoms and the overall effect was quite pleasant, and as i have stated at the time in the appropriate thread, it is one of the few uses i have for mxe (not being that mcuh of a dissasociative fan).
 
Transform said:
I don't think we can really say this. In the same way that SSRIs block the effects of MDMA instead of causing dangerous release, MXE should do the the same to the SRA effects of aMT.

Even if the combination of SRI and SRA could cause SS, this ought not to be a problem for MXE as its SERT affinity is not too high.

In moderation I do not think there is any reason to worry, but caution should be exercised.
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Fair point, though I'd like to double back from being so sure about the safety of aMT with any serotonergic compounds, as having looked a little deeper at it, there's evidence pointing towards aMT being a stronger MAOI than I might have thought previously, more along the lines of something like harmine. Experience reports seem to suggest otherwise as there seem to have been no MAOI like cases of serotonergic toxicity until incredibly high doses that would likely be toxic in their own right - but anyone reading should take my previous words with a pinch of salt and definitely stay cautious if combining this with monoamine releasers/reuptake inhibitors for that reason.

As for MXE's SERT affinity, yeah it is rather low, given the reports of bad interactions with SRIs/SRAs by many users though I'm a little puzzled and wondering if the cases of problems are a result of incredibly high doses or if there are other factors at play here.

Either way, if you are going to go ahead with this combination, keep doses low - I'd still advise sticking to Ketamine if you want to combine a dissociative in this example though, and in fact in most combinations I'd advise Ketamine over MXE simply due to it generally being accepted as the safer of the two (in the short run at least).
 
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