aMT/Mescaline neurotoxicity

[Bucklecroft Rudy]

http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2009.05141.x/full#ss3

This article (posted by another bl'er) has confirmed misgivings ive had for mdma. Though there are no human test subjects its still compelling and the projected risks are too severe to play jeopardy with. Ive heard that Mescaline and aMT are the closest alternatives to mdma ( excluding the 2cx family and a few rare phenethylamines) and have similar mechanisms of action partic. in relation to 5ht/DA.

My first concern however would be for the lengthy duration - any neurotoxicity would be sustained in this case. Second do we have a conclusive metabolite profile? Lastly has their pharmacology been established and cytotoxicity excitotoxicity and oxidative stress etc been ruled out?Very few studies have been conducted on either so this is all academic speculation at best, guesswork at worst

 

[ebola?]

and have similar mechanisms of action partic. in relation to 5ht/DA.

Mescaline does not. On paper, there's not reason to expect it to prove neurotoxic. However, because AMT is a tri-monoamine releaser, it should present MDMA-like neurotoxicity.

ebola

 

[cannibalsnail]

Is AMT as Neurotoxic as MDMA? Surely the vastly lowered profiles and lack of Alpha-methyl-dopamine metabolization would decrease the neurotoxicity to negligible levels?

 

[ebola?]

What do you mean by "vastly lowered profiles"? Alpha-methyl-dopamine, being a dopamine antagonist, will make you feel like shit, but it's unclear that it causes increased oxidative stress. Given that the vast majority of it is formed in the liver, it's unclear that significant amounts of AMD appear in the brain (remember that dopamine does not cross the BBB).

ebola