• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

aMT death analysis

most of the common solvents are innocuous enough if you ingest less than a few mL. most of them evaporate and would be present only at trace levels in a "finished" product. water, isopropanol, ethanol, acetone, ether, thf, ester solvents, dmso are all safe in fairly large qtys. (not that I would drink any but water). even the "harsher" solvents like hexanes, dichloromethane, toluene, even methanol are safe if consumed in very limited quantities. they get metabolised and/or extcreted easily. the exceptions are a few things like carbon tet, dmf, chloroform, methanol, glymes, benzene, and usually they are avoided for this reason.

many simple synthons used in drugs are actually also flavour/fragrance components or found in nature at some level. for instance the immediate upstream precursor of mdma/mda (safrole) used to be present in root beer until the FDA decided it "causes cancer in rats" suspiciously close to the time MDMA was rising in popularity. another benefit is that in essentially all reaction workups, metal salts remain as polar water soluble compounds and the compound you want goes into an organic solvent, making "washing" quite easy (also most metals/salts are extraordinarily poorly soluble in organic solvents).

there is also a growing field of "green chemistry" focused on making molecules safely, quickly, and with the lowest impact to the environment (using low impact chemistry). for instance chromium can be relaced in many cases with a wide variety of other oxidation techniques, for instance one involving aqueous sodium hypochlorite or something (essentially household bleach, decomposes to salt and oxygen)

however - if you cannot conclusively prove your material is free of metals, or an outright toxin, then don't bioassay it. simple as that.
you can also devise a purification technique for your drug of choice if you do a little research. the US pharmacopiea has a big book of stuff like that. or, for most nitrogenous drugs, look up acid-base extraction.
 
well here at uni i dont have direct access to analytical equipment being a chemical engineer major (some find it hard to believe at first), but that's because it's all about unit operations, mass transport, thermo, etc. in fact, only one semester of organic chemistry is required for the BA here. im guessing a lot of students have a hard time with orgo (it was my favorite subject).

anyway, id love to get some good figures on research chem identification/composition. even when i search all these journal databases i find little information on almost any compound. im hoping in intermediate orgo i will be able to assay some of these using gcms and nmr from a wide range of vendors.
 
id love to get some good figures on research chem identification/composition. even when i search all these journal databases i find little information on almost any compound.
Click to expand...

The long and short of it is: pick a similar compound with a known analysis method and work from there. Some "analogues" are actually present in mass spectral databases; others can be discerned by a little math and/or a copy of Chemdraw.

Also, look at forensic and toxicology journals.
 
ive taken that route before yes, but there are 'endless' methods to reaching the same goal. i would be much more comfortable having good analysis on vendor (and even street) products from around the world.

i have a feeling that quite a few people arnt going to give much thought into their seperation processes because what they are creating (precurosor or final product) is "not for human consumption", so the thought does not pass. some of the reaction/separation processes can take a lot of time and require much attentiveness, and when corners can be shaved in the industry...

sorry i am getting off topic. but i would like to hear the reasoning behind...

atara: "...either this guy took amphetamines with his AMT (a good way to kill yourself if I've ever heard of one)..."
 
AMT is an indole analogue of amphetamine investigated in the 1960s as [a] ... monoamine oxidase inhibitor.
Click to expand...

MAOI + amphetamines are generally not a good plan. Even though AMT is only a mild MAOI, at higher doses it can be significant enough to warrant danger when combinign with some other strong monoamine releasers.

i have a feeling that quite a few people arnt going to give much thought into their seperation processes because what they are creating (precurosor or final product) is "not for human consumption", so the thought does not pass.
Click to expand...

most legit "research chemicals" are meant to be analytical standards for e.g. toxicology or cell assays. so they are intended to be really pure, but again, not meant to be eaten (as part of good lab practice) and the few clandestine labs that are making it "not for human consumption" *wink wink nudge nudge* probably still do a best-effort purification, because more than a few bad batches and people either die or stop buying your shit. bad news spreads pretty quickly.

despite my best arguments the fact remains that some people are just assholes who will sell anything to make $. or rather, say anything to relieve you of your money.
 
My friend died this week from an AMT overdose they think he took over a gram he bought on the internet died infront of his friends quietly and suddenly. He was an experienced drug user but that didnt matter. His vision was morphed so when attempting to take another bomb he had actually taken 3. They were taking them in 100mg doses. Its sad someone has to die for things to change.
 
You must log in or register to reply here.
Top