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aMT and mirtazepine- what kind of interaction?

pofacedhoe

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Mar 5, 2008
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my friend is on mirtazepine but i am interested in introducing him to alphamethyltryptamine. i am aware that aMT and ssri's dont go together well


this is what i found on wiki


Interactions

The potential for dangerous drug interactions with mirtazapine is considered to be very low, if not completely negligible. As a serotonin receptor antagonist, mirtazapine will not cause serotonin syndrome at any dose, nor is it capable of causing tyramine-induced hypertensive crisis, unlike the SSRIs and MAOIs, respectively. In fact, mirtazapine can actually be used to treat serotonin syndrome.[119]

Mirtazapine may, however, increase the effects of warfarin and sedative drugs, such as alcohol, benzodiazepines, and barbiturates,[citation needed] and it has also been reported to reduce or block the effects of some street drugs including hallucinogens such as MDMA, LSD and magic mushrooms.[citation needed] Carbamazepine and phenytoin decrease effects of mirtazapine.[citation needed] Cimetidine, azole-antifungals, HIV protease inhibitors, erythromycin and nefazodone may increase effects of mirtazapine.[citation needed]

Mirtazapine in combination with an SSRI, SNRI, or TCA as an augmentation strategy is safe and is often used therapeutically.[89][94][95][96][98] Mirtazapine and MAOIs are said to be contraindicated by some sources; however, there is no true indication that this is actually the case, and there is no proper literature on the subject warning against the combination whatsoever. Only a single study has mentioned anything significantly important regarding the combination, and they reported that it does not result in any incidence of serotonin-related toxicity.[120] However, mirtazapine has been associated with inducing hypertension in clonidine-treated patients.[121]

so whats info can you give?
 
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