Bucklecroft Rudy
Bluelighter
How does 5 htp affect aMT? Ive read that 5htp causes receptors to be activated which prevent/inhibit mdma sert. release hence the disgruntled reports from preloaders.
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aMT 5 htp interaction
- Thread starter Bucklecroft Rudy
- Start date
Thou
Bluelighter
I'd caution against it. aMT acts as a selective (albeit weak) MAOI (http://www.bluelight.ru/vb/archive/index.php/t-38982.html).
Why would you want to mix the two? I believe aMT is serotonergic in its own right. You're playing with fire without a real advantageous goal. I don't have experience with the combination personally, but anything with even a REMOTE chance of causing A) hypertensive crisis due to IT-290's MAOI activity, or B) Serotonin Syndrome (personal experience with this, hospitalization. Not fun).
Be safe.
Or were you asking about the pharmacology of two in combination?
You'll need to clarify in that case because at that point this would become an ADD discussion thread.
Why would you want to mix the two? I believe aMT is serotonergic in its own right. You're playing with fire without a real advantageous goal. I don't have experience with the combination personally, but anything with even a REMOTE chance of causing A) hypertensive crisis due to IT-290's MAOI activity, or B) Serotonin Syndrome (personal experience with this, hospitalization. Not fun).
Be safe.
Or were you asking about the pharmacology of two in combination?
You'll need to clarify in that case because at that point this would become an ADD discussion thread.
Bucklecroft Rudy
Bluelighter
its a hypothetical question more than anything and it does probs belong in bdd or add- ive got maoi + sert. agonist/reuptake inh. = v. bad drilled in thanks to bl lol saved my sorry ass on many ocassions. My thought was along the lines of preloading for a period stopping for a number of days to allow upregulation and then dropping. Would the heightened sert levels potentiate the amt in that scenario?
pofacedhoe
Bluelight Crew
probably would make you very nauseaous
5-HTP is typically used for comedowns of the more heavy serotonergic releasers or for pre-loading. Over time I have gotten the feeling that pre-loading is not such a good idea because it usually hardly seems to work yet can be unpredictable and do too much of a wrong thing. These drugs are meddling with your serotonin system already, I would not consider preloading stocking up extra serotonin reserves but adding to unbalance.
Post-loading for comedowns has proven to not be statistically significantly worthwhile in a small-scale double blind study my (granted not scientific) research group of volunteers like I was at the time. I suppose it shouldn't pose a threat but AMT doesn't usually cause a dip like MDMA does to begin with.
I'd forget about 5-HTP for these purposes. What I would use it for though is chronic supplementation at night before going to sleep in periods in between use of serotonergic drugs to provide your metabolism with sufficient precursor to help in natural restoration. But eating healthy and sleeping regularly and enough is probably the best thing to do as a general rule and in doing so I doubt the 5-HTP would be of that much extra use, or rather 'need'.
Post-loading for comedowns has proven to not be statistically significantly worthwhile in a small-scale double blind study my (granted not scientific) research group of volunteers like I was at the time. I suppose it shouldn't pose a threat but AMT doesn't usually cause a dip like MDMA does to begin with.
I'd forget about 5-HTP for these purposes. What I would use it for though is chronic supplementation at night before going to sleep in periods in between use of serotonergic drugs to provide your metabolism with sufficient precursor to help in natural restoration. But eating healthy and sleeping regularly and enough is probably the best thing to do as a general rule and in doing so I doubt the 5-HTP would be of that much extra use, or rather 'need'.
clubberdude
Bluelighter
I am sceptical about 5-HTP. In my experience it does very little to me either as an antidepressant, sleeping aid or pre-loading agent (though haven't used it much in this capacity, so experience is very limited here). I would have thought that, as 5-HTP only has a 2-3 hour half life, the blocking of effect would only last perhaps 6-8 hours. A bigger issue you might have of course is the fact that aMT is an MAOI. I have seen aMT potentiate both Speed/MPA and MDMA massively, even dosing the second agent several hours after the first. In fact the Speed combination (and I wasn't feeling the speed massively) with aMT taken a few hours later was perhaps the most stimulated I've felt.
Going slightly off-topic here (sorry), but something thouart_that suggested (about the pharmacology of aMT - as an ADD type discussion), would be a pretty interesting discussion. An observation I have made about combining DOC with aMT (not at the same time, with a 5-6 hour gap) greatly increased my tolerance to DOC, and eliminated most of DOC's rather mindbending psychedelic effects (this is on insufflated doses of 7-8 mg, though administered over a few hours - that should have inverted my mind). This has made me wonder about aMT's mode of action. I wondered whether the aMT blocks the DOC from reaching the receptor site properly, or does aMT have a mild reuptake inhibition effect. Either way, its 5HT affinity must be quite strong if it can compete over DOC!!! I've also noticed that it can take a lot longer to come up on DOC whilst on aMT and the DOC body feeling isn't strong and takes several hours before it gets going. Very little of the body energy seems to be there.
On the other hand, the level of euphoria experienced from this combination is second to none (far, far stronger than aMT alone - surpassing MDMA, but for around 18 hours!) so something is obviously happening with the DOC. I have, however decided, that given how valuable DOC is, and how personally sought after are its psychedelic effects, that I won't be combining them again. Although the euphoria was incredible, I feel its a waste of DOC, particularly given its rather unique psychedelic properties (I nickname it the intellectual psychedelic as I always feel far more intelligent whilst on DOC, almost like my IQ is substantially increased, and experience vastly improved intellectual fluidity).
Going slightly off-topic here (sorry), but something thouart_that suggested (about the pharmacology of aMT - as an ADD type discussion), would be a pretty interesting discussion. An observation I have made about combining DOC with aMT (not at the same time, with a 5-6 hour gap) greatly increased my tolerance to DOC, and eliminated most of DOC's rather mindbending psychedelic effects (this is on insufflated doses of 7-8 mg, though administered over a few hours - that should have inverted my mind). This has made me wonder about aMT's mode of action. I wondered whether the aMT blocks the DOC from reaching the receptor site properly, or does aMT have a mild reuptake inhibition effect. Either way, its 5HT affinity must be quite strong if it can compete over DOC!!! I've also noticed that it can take a lot longer to come up on DOC whilst on aMT and the DOC body feeling isn't strong and takes several hours before it gets going. Very little of the body energy seems to be there.
On the other hand, the level of euphoria experienced from this combination is second to none (far, far stronger than aMT alone - surpassing MDMA, but for around 18 hours!) so something is obviously happening with the DOC. I have, however decided, that given how valuable DOC is, and how personally sought after are its psychedelic effects, that I won't be combining them again. Although the euphoria was incredible, I feel its a waste of DOC, particularly given its rather unique psychedelic properties (I nickname it the intellectual psychedelic as I always feel far more intelligent whilst on DOC, almost like my IQ is substantially increased, and experience vastly improved intellectual fluidity).
pofacedhoe
Bluelight Crew
one drug that was vastly improved with 5htp a few hours before was 6apb.
unlike the mdma 5htp combo nothing was dampened and the euphoria was much closer to mdma
unlike the mdma 5htp combo nothing was dampened and the euphoria was much closer to mdma
I think all the theories about 5-htp doing anything to prevent alleged brain damage from MDMA were based on huge doses injected directly into a rats brain. Just taking a tablet orally does absolutely fuck-all.
Of course you'll get lots of people saying "I took a tablet of 5-htp and noticed a difference" but that'll just be placebo. If you gave them a tablet consisting of their own dried excrement and told them it was the latest in pre-loading they'd "notice the difference" too.
Of course you'll get lots of people saying "I took a tablet of 5-htp and noticed a difference" but that'll just be placebo. If you gave them a tablet consisting of their own dried excrement and told them it was the latest in pre-loading they'd "notice the difference" too.
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clubberdude
Bluelighter
Thats because 5-HTP does do absolutely fuck-all.