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  • BDD Moderators: Keif’ Richards

Amphetamine + Tramadol + Diphenhydramine. Unsafe combination?

Saucy

Saucy

Bluelighter
Joined
Aug 20, 2009
Messages
324
Hey, I'm just looking for a quick answer regarding the safety of what I have taken today.

T+0:00 15mg Hydrocodone
T+0:30 150mg Tramadol (Serotonin Releaser)
T+0:45 75mg Diphenhydramine (SSRI)
T+1:00 20mg Rascemic Amphetamine (Serotonin Releaser)

I was careless in taking the last two, and did so without thinking it though. I feel rather sick now, and not high in the least. Is what i have taken dangerous. Would these doses pose a risk of Serotonin Syndrome?
 
d-amp DOES release a teensy bit of serotonin
but that IS unsafe, tramadol increases the risk of seizures, and ampz can cause you a seizure
look up how ODB died.
 
K'd-OUT-in-AZ said:
d-amphetamine does NOT release serotonin and Diphenhydramine is NOT an SSRI its an anti-histamine. Methamphetamine release serotonin, not amphetamine
Click to expand...

It's one thing when someone who is ignorant about a topic provides incorrect information. That I can tolerate. But when someone is so arrogant that they would contradict people who actually do know what they are talking about with patently false information, and without even bothering to take the two seconds that it would take to double check their facts-- that I can not stand.

Diphenhydramine is ABSOLUTELY an SSRI. Here's one source:
http://meeting.chestpubs.org/cgi/content/abstract/134/4/c4002
And there are only about a million more that reference diphenhydramine's SSRI properties that are available to anyone with a computer.

Amphetamine (both enatiomers) absolutely does promote the release of serotonin. And sure, it's equilibrium dissociation constant for serotonin is somewhat lower than of dopamine and norep, but a given dosage of rascemic amphetamine will actually release MORE serotonin than an equipotent dose of rascemic Methamphetamine because methamphetamine's levorotary isomer has such a high EC50 value with regard to serotonin release.

So next time you decide to contradict people on basic facts, at least do your research first so you won't be wasting other people's time, or worse yet, misleading other people into believing false information.
 
^^ yeah, I think before you start combining all sorts of pyschotropic drugs at once, you should become a little more aware of their effects/interactions...BEFORE you take them. Not much good to do your homework after the fact. In your case, I'd be most worried about combining the amphetamine with the tramadol, as said, both can lower your seizure threshold, especially when taken together. The dosages you took aren't terribly huge, so that is in your favor. However, in the future, I would avoid the combination. You can check for simple drug interactions using a site like drugs.com.

And the amount of diphenhydramine you took is pretty low, so the pyschotropic effects will be extremely limited. If anything, it may help with the itches you may get from the opiates.
 
You don't have to be a dick about it, a simple your WRONG would do. I was unaware that diphenhydramine was an SSRI, that is new to me but as for amphetamines I don't believe they release serotonin, if you could provide a link or copy some literature then you can disprove me but as I know amphetamine does not release serotonin, only methamphetamine. But don't quote me on that, just as it would have been a good idea not to quote me on the diphenhydramine.

So if diphenhydramine is an SSRI, would combining it with Effexor cause potential serotonin syndrome? That is something I'd like to know.
 
I didn't mean to be a dick. This combination is just making me feel sick and pissed off at everything.
 
Amphetamines do effect serotonin, but as stated, not nearly as much as they effect NE and DA. There is a risk of serotonin syndrome when combining amphetamines with an SSRI, and combining amphetamines with effexor can run you the risk of serotonin syndrome along with the risk of synergistic effects with increased NE concentrations.

Benadryl does have mild SSRI properties, but extremely minor at low to moderate doses and is not therapeutically relevant when dosing with tramadol or amphetamine. Benadryl is an inhibitor or CYP2D6, which may actually decrease the analgesic effect of tramadol due to preventing tramadol's conversion to more active metabolites. This is only for the analgesic effect of tramadol, tramadol's NE and 5-HT reuptake inhibition will remain intact.
 
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