Amphetamine pharmacokinetics

[hussness]

EtOH definitely gets in the brain, but back to AMP metabolism, phenylmethylenealphapiperidines (PMAPs) don't have this problem.

Ritalin/methylphenidate does, due to its Bz-(CO2Me)-R group, but it's not a strict PMAP.

EtOH --> CH3CO2H.
Bz-(CO2Me)-R --> Bz-(CO2-)-R + MeOH.
MeOH --> HCO2H.

Does cocaine have this toxicity issue? What kind of levels of acute formic acid metabolite toxicity can be tolerated without long-term effects?

 

[Morb]

^^MattPsy brings home the Au here.

Must have seen that 25 years ago on facts of life. Tootie for sure was helping Natalie I believe, "what do you say if somebody steals your gold? A U! Come back here with my gold!" but I digress...

 

[nanobrain]

...fact that selegeline - an MAO-B inhibitor - prevents MDMA induced neurotoxicity, which proves something...

may i ask as to how this became a fact?

 

[bigmac74]

may i ask as to how this became a fact?

I posted references in the thread...

[1], [2] & [3].
^^

Incubation of MDMA treated cells with the SERT inhibitor, fluoxetine (500 nM) or the MAO-B inhibitor, L-deprenyl (0.1 mM) for 30 min prior to DA, significantly blocked free radical production and cell death.

The monoamine oxidase-B inhibitor L-deprenyl protects against 3,4-methylenedioxymethamphetamine-induced lipid peroxidation and long-term serotonergic deficits.

Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum.

 

[MattPsy]

Must have seen that 25 years ago on facts of life. Tootie for sure was helping Natalie I believe, "what do you say if somebody steals your gold? A U! Come back here with my gold!" but I digress...

What are you talking about ?
Yeah, it would appear you can prevent neurotoxicity by two methods: Either keep the 5-HT levels high by the use of an SSRI, avoiding a 5-HT concentration "crash" and the associated subsequent uptake of DA instead of 5-HT, causing free radical generation OR inhibit the enzyme responsible for the production of free radicals...

 

[Synapse999]

There is alot of things that prevent neurotoxity with this drug, by itself.
but that is a seperate topic in itself. heh

 

[nanobrain]

yes, i read these some time back, but how do a few semi-conclusive experiments make it to fact status? pharmakodynamics is a fairly entangled beast, MAO aint MAO and there's all sorts of other factors that necessitate inclusion before blanket statements of fact may be pronounced.

 

[Synapse999]

blanket statements of fact may be pronounced

Thus is life. ;x

Though, could be worse. Live life by the word of the media ;p

Carbs are the enemy!