• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio | someguyontheinternet

Amphetamine Neurotoxicity and Tolerance Reduction/Prevention III

Since nicotine is an antagonist at 7, this would make it attentuate toxicity too probably.


http://www.ncbi.nlm.nih.gov/m/pubmed/16823800/ I'm not positive what this is saying
 
Last edited:
hey guys,

quick question if you don't mind.

would you consider taking tyrosine in the morning the day i take amps at night in any way dangerous or not recommended.

as far as my understanding goes - since its only a precursor for dopamine it would be okay.

am i right ?
 
Tyrosine shouldn't interact with amphetamines... it's already present in your diet. The rate limiting step in dopamine synthesis is conversion of tyrosine to L-DOPA.
 
Very little on zinc, very little

'I come bearing fruit', or, Zn

This one demonstrates several bonuses, but I meant it for nmda antagonism. Also an ampa agonist and ad potential its own, as Mg. http://link.springer.com/article/10.1007/s00726-009-0412-y

If I'm reading this right, which I'm probably not, zinc is a DRI
http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002909

One study I couldn't link found it increased bdnf and 5ht1a/2a transmission

This one makes my pants soaking, its insta-gasm http://online.liebertpub.com/doi/abs/10.1089/cap.2010.0073

My one question is is their a synergistic beneficial effect when taking zinc with magnesium for tolerance or no. I'm guessing due to the diverse nature of its effects, yes.
 
Ho-Chi-Minh, I guess it couldn't hurt to take them together? I no longer use amphetamine but I've seen a lot of Mg supplements also have zinc combined... ZMA is one that comes to mind of the two. I have a magnesium glycinate blend that includes zinc in it too.
 
Relatedly: Why is MDMA neurotoxic to serotonergic neurons? normal amps and SSRIs certainly aren't 5-HT-toxic. Is something similar to the combination of VMAT2 inhibition and reactive neurotransmitter metabolites what goes on here as well?

DJ Henru, SSRIs after meth would likely reduce toxicity, similarly to SSRIs after MDMA. This is ignoring serotonin syndrome, which I know little about, but involves hyperthermia, in this case on meth, which would be most toxic.
 
5ht2a downregulation isnt a sort of pretense for neurotoxicity to occur? Also SSRIS I think can sometimes run the rist of SertSyndrome, thus perhapse they are if SS is presenting itself?
It doesn't surprise me that you suggest an SSRI post administration possibly reduces toxicity, because SSRI's arent neurotoxins in the same respect at all. A brain not used to being on MAmp certainly would function differently then one that is effected with an antidepressant.

*WHY I ASK*I have a loved one compulsively using & not cessating his SSRI, & recently getting very ill.
Its a dreadful ordeal to see someone go through.


I want to think about a way to recover from such health problems could be tianeptine? I saw it helps MDMA neurotoxicity. Would this be viable for SS induced through use of MAmp?
Good vibrations and prayers sent to my friend feeling better
 
Last edited:
TCM, as I recall it has something to do with the inherent toxicity of dopamine when it auto-oxidizes after being taken up by SERT into cystistolic/vesicular stores, as in, in the presence of surroundings which aren't base enough to handle it without being damaged. I bet this happens with methamp and even amp given the structural similarities of the three major monoamines but to a far lesser extent. I read this awhile ago though.

If down-reg of 5ht2a caused neurotoxicity, mushrooms/LSD, basically the psychedelics, and atypical anti-psychotics would be under even more scrutiny.

One could make the case that SSRIs are toxic. For instance, inflammation causes the bdnf to be released which leads to most of their neuro-protectiv/generative properties.

Nevertheless, in basic psychopharmacology, SSRIs have one simple action on serotonin, whereas meth/MDMA trick the body and insinuate themselves as endogenous.

THC has been shown to help reduce MDMA toxicity and fluoxetine to help recover the brain from mdma-induced damage, doesn't make it safe, or true for that matter. And despite similarities meth is quite different from MDMA IMO.

I'd be more worried about dopaminergic toxicity.
 
DJHENRU said:
5ht2a downregulation isnt a sort of pretense for neurotoxicity to occur? Also SSRIS I think can sometimes run the rist of SertSyndrome, thus perhapse they are if SS is presenting itself?
It doesn't surprise me that you suggest an SSRI post administration possibly reduces toxicity, because SSRI's arent neurotoxins in the same respect at all. A brain not used to being on MAmp certainly would function differently then one that is effected with an antidepressant.

*WHY I ASK*I have a loved one compulsively using & not cessating his SSRI, & recently getting very ill.
Its a dreadful ordeal to see someone go through.


I want to think about a way to recover from such health problems could be tianeptine? I saw it helps MDMA neurotoxicity. Would this be viable for SS induced through use of MAmp?
Good vibrations and prayers sent to my friend feeling better
Click to expand...

SSRI's are pretty damn safe and effective, you have nothing to worry about unless other drugs are combined. Please do some reading on serotonin syndrome before worrying, it pretty much only pops up with really out there drug combinations.

Tianeapine is a really sketchy drug, none of the studies on it are high quality. Not sure how it enjoys its amazing Internet reputation TBH.
 
DJHENRU said:
I did note that it was combined with M-amp
Click to expand...

And the combination of both MDXX and (meth)amphetamine with SSRI's has been documented to be neuroprotective if anything. I mean baring accidentally a whole bottle of Paxil not much should happen to the best of my knowledge. When SERT is inhibited it's transport can't be reversed.

Hope that makes sense
 
The caveat about simultaneous amp/ssri use is that one may find the combo makes the amp less effective.

SSRIs, although super safe and effective compared to other drugs with utility against the same mental disorders, they definitely diminish the spectrum of emotion one can feel. In my experience, if you feel pleasure and anxiety both on a 10/10 scale, a SSRI will cap these opposing (yet strong) emotions at ~7/10. Paying this price is definitely worth it if you're 10/10 anxiety is debilitating.

So, in regards to amp, if you derive therapeutic effects from its pro-motivational, pro-mood effects, SSRIs may very well limit this. Otherwise, it is a terrific combination for those with comorbid issues with ADD/ADHD.
 
A la contraire, I recall reading that the combination is actually synergistic, sympathomimetically (god I love that word, someone give me props) speaking.
 
Who else thinks ricuarte's research was poorly done?

I'm glad to see therapeutic primate dosing, but waiting just two weeks is questionable in my opinion, still well within the realm of tolerance related changes in the brain
 
I know we are in the ADD but for what it's worth I would like to say the following: In my recent binges involving daily using but with some drug assisted sleep (say 4-5 hours per day average, although now I am pulling a 36 hour run now that i notice...) I have hit megadose territory of acetyl l-carnitine (1-2 g), alpha lipoic acid (200mg), and selenomethionine (200mg or mcg or whatever) 2-3 times each day. There are some multivitamins thrown in there from time to time but honestly since I have had that regimen I have felt TONS less head buzzing/brain cell popping wickedness that was usually the norm for me beginning day 3 of a binge like this. I'm not saying that it's not perhaps some effect that stack has on my lack of sleep instead of neurotoxicity (can you even FEEL neurotoxicity? most say not), but owing to those studies posted around the web on the full attenuation of meth induced neurotoxicity by similar such megadosing, I would say that these really are keeping back oxidation from the surrounding neurons in a way that has perceptible effects -- not huge, but at least significant enough for a rationalizing drug abuser to actually notice. The web scored me a damn lot of these supplements cheaply from quality brands with not all that much scrutinous searching. YMMV but megadosing is key, it's what all those scientists do anyway so why not us.

If this post is too informal for this thread by all means please move it elsewhere; I looked and looked but could not find a suitable home. Loving this thread tho thanks so far everybody.
 
You must log in or register to reply here.
Top