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Amphetamine Neurotoxicity and Tolerance Reduction/Prevention III

bleh, now I feel I killed the thread. I promise that it did not quite have the the same extremely diffuse/ineffective quality of sublingual as normal, I just presented it all retarded with bias of having no idea what I was doing and impressed with JB correcting me with more than I needed to know.
 
Proper zinc supplementation -- in a pilot study -- reduced the necessary AMP dose needed to achieve the desired effects by ~37%.
 
Tussmann said:
Proper zinc supplementation -- in a pilot study -- reduced the necessary AMP dose needed to achieve the desired effects by ~37%.
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http://www.ncbi.nlm.nih.gov/pubmed/21309695
BAM! Sauce.

Keep in mind the study identifies the midwestern US as a place with a high rate of zinc deficiency, and a decent multivitamin provides 25-50mg of zinc a day (GNC Men's Health is the one I "referenced"). The study reports results at 30mg/day elemental zinc in children, so perhaps it would be a higher number in adults.

EDIT: Same thing goes with iron deficiency/multivitamins
http://www.ncbi.nlm.nih.gov/pubmed/21186968
 
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Hmm I wonder how this relates to competing with magnesium. MG I found kinda lets me rather abuse more without as much side effects. Not necessarily always a lowering of tolerance in a total effect.
 
Took 2g of d-amphetamine over a year then quit in July 2012. Over the course of this period I took dxm and mxe 1-3 times per week but never while on or coming down from amphetamines. I regularly took magnesium, calcium, Coenzyme Q10 and occasionally took phenibut for amphetamine comedowns and aniracetam with acetyl-choline. Since my use I have used lengthy doses of l-tyrosine, 5-htp, l-phenylalanine, l-carnitine, n-acetylcarnitine, oxiracetam and aniracetam with acetyl choline, SAM-e, zinc and vitamins: a, b2, b6, b12, d. I currently only take n-acetylcarnitine regularly and have chronic mood swings including depression with suicidal ideation(though I live with 3 friends and am building a good life). Could my past amphetamine use be causing an imbalance in my neurotransmitters? If so are any neuroprotective supplements able to help put my body in balance?
 
Spacegirafe, d-amp doesn't work on serotonin very much at all and AFAIK isn't toxic to serotonergic neurons in the way meth and MDMA are and I doubt it would be affecting you now from the amp.

However, you said you take acetyl-carnitine which whilst said to have an anti-depressant effect can also induce depression whilst on it due to it rising the levels of choline... Maybe try stop it for a week or two and see how you feel?
 
I mean though, the dopaminergic theory of depression is gaining steam, and I know that nris are used for depression sometimes (notwithstanding SNRIs).
 
Oh yeah don't get me wrong, dopamine plays a role in mood, I'm not saying that in my last post. At only 2G spread over a year with supplementation I doubt how your feeling now is because of your use. I think the alcar could be affecting OP thats what I meant as it is known to cause depression in some due to increased cholinergic activity.

ALCAR is also proven to reduce neurotoxicity aswell as/combo of ALA whilst on the topic, have mentioned this before.
 
@MrSpeedyG
The ALCAR has been improving my mood and I was only 125-140lb during that spread so 120mg would keep me up for 3-4 days. I had 2 straight weeks of fevers and psychosis when I quit which is why I worry that the effects could be ongoing. I'm 160lb since quitting 11 months ago, my body has returned to normal but my mind still strays all over the place.
 
I see, is your mind straying all over the place in a way where you seem to have a lot of inner dialogue/your mind narating or talking to itself a lot?

Maybe try Wellbutrin? It's the only anti-depressant I would suggest someone to try really, it's a cathinone derivitate and acts as a NDRI and might be worth a shot, allthough I still would personally drop the ALCAR and see what effect that has.
 
Before jumping to monoaminergic antidepressants, don't forget to evaluate diet, environment, and lifestyle. Your immediate surroundings, and things like how recently you've eaten (and what kind of food) and how much physical activity you do will also play a big role in your mood.

And consider things like CBT, as well.
 
I highly recommend against the use of Wellbutrin (Buproprion) concurrently with amphetamines.... Very nasty shit right there, asking for a very nasty shitty time, asking for a very nasty shitty bloody time if enough is ingested or ROA's tampered with...

$0.02, be safe, not sorry.
 
Oh yes, wellbutrin may be baed in structure off a dopamine/norepinephrine realeaser but it simply isn't recreational...Unless a seizure is what your aiming for, but that shouldnt be a worry if you used as precribed.
 
Well I have done it again. I am rx racemic amphetamine and dextroamphetamine and I usually strictly only binge on the dex but I have taken probably 300 mg give or take of adderall within 48 hours... Now I know why I don't use adderall recreationally... All amphetamines have the issue of wanting a redose, and I am sure the amount of l-amphetamine in my system right now is definitely not good and related to this thread.. Neurotoxicity hopefully not in my brain, but when ya dose as high as 100 mg l-amphetamine it cannot be good. I have taken a lot of magnesium chelate.
 
I saw this and I must concur with you on tolerance never really returning to baseline after 150 mg + range. It's because amphetamine is a STRONG cns stimulant and your body will remember it just like your cns will remember the amount of weight you can push or pull after taking a break from heavy training.

synthetix said:
i believe that at lower doses, sugar imbalances are the primary causes for neurotoxicity, however when amphetamines are abused in higher doses that are insanely high, oxidative stress is the primary cause for concern although also linked into sugar imbalance too.

from my experience (i take dexedrine daily, 20mg twice a day) when i first started taking my medication i abused the hell out of it for a good month - being up to 150mg a day type thing, snorting it, all sorts of crap. i then came off it for a good 9-10 months, and my tolerance had not reset, but had gone down to a level at which i could re-use the drug at its therapeutic levels once again. i no longer abuse my medication and NEVER go higher than 40mg a day. sometimes i even forget to take my doses. i think that amphetamine tolerance is ever lasting, there is no way for it to ever decrease to base line. during my 10 month break lets say, i was on several supplements, ZMA, vitamin E, conenzyme Q10, selenium, melatonin etc - a whole bunch of anti-oxidants to say the least and they perhaps reduced my tolerance (actually, perhaps if i hadn't of taken them, my tolerance would never have gone back down?) thats an interesting theory.
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