Stimulants Amphetamine endogenous opioid release?

[MrSpeedyG]

IIRC amphetamine is said to induce endogenous opioid release... Not sure if it is significant but a thought came accross my mind as I am currently on 30mg of d-amp (with a super high tolerance) and I am feeling no effects as usual, heart rate is normal and mouth is a little bit dry, however I feel super chilled and relaxed which is not normally what it does to me, usually it will make me an anxious wreck who is irritated at everything, everyone and wired even at thise dose unless I mega dose into tripple digit mg dosages then i get some sort of dopamine rushy feel but its mediocre.

Basically I feel nothing but relaxed and mellowed, not tired but quite hazy and floaty, kind of pleasant actually I also feel sort of content kind of but not in a typical speed-god-like feeling and I correlated that with amp inducing opitate release... what I am asking is it possible it is overpowering whatever tiny effect the amp is having on me seeing as I am super tolerant to any typical dopamine effects from it?

Is anyone here have a high tolerance to amps find if they dose low enough so they dont feel anything find they have a sedating opitate like push? I have never done opiates but how I feel right now is close to what I have always imagined a low dose of opiates would feel... Wierd! Almost like a floaty, stoned but still have a bit of control and no brain fog, kinda.

Anyway just curious on peoples thoughts on this and if anyone else ahs experienced it?

Cheers!

Just an update, btw my pupils are normal size if anything a litle bit smaller and I am sort of nodding a bit, actually enjoying this and no I am not tweaked either faaaaar from it, in la la land mellow and chilled out as fuck much prefer this over speeding

If this is what opiates feel like, then I should deffintly keep the fuck away!

 

[Tryptamino]

As far as I know amphetamine does not stimulate endogenous opioid release, although I'm not sure. I have a tolerance among tolerances to amphetamines and I know that low doses will not give me any opioid-like effect, however mild. In fact nothing about opioids and amphetamines in my experience are even slightly similar.

 

[MrSpeedyG]

Heres where I read it just found it http://www.ncbi.nlm.nih.gov/pubmed/22386378 !

Endogenous opioid release in the human brain reward system induced by acute amphetamine administration.

We aimed to demonstrate a pharmacologically stimulated endogenous opioid release in the living human brain by evaluating the effects of amphetamine administration on [(11)C]carfentanil binding with positron emission tomography (PET).
METHODS:

Twelve healthy male volunteers underwent [(11)C]carfentanil PET before and 3 hours after a single oral dose of d-amphetamine (either a "high" dose, .5 mg/kg, or a sub-pharmacological "ultra-low" dose, 1.25 mg total dose or approximately .017 mg/kg). Reductions in [(11)C]carfentanil binding from baseline to post-amphetamine scans (ΔBP(ND)) after the "high" and "ultra-low" amphetamine doses were assessed in 10 regions of interest.
RESULTS:

[(11)C]carfentanil binding was reduced after the "high" but not the "ultra-low" amphetamine dose in the frontal cortex, putamen, caudate, thalamus, anterior cingulate, and insula.
CONCLUSIONS:

Our findings indicate that oral amphetamine administration induces endogenous opioid release in different areas of human brain, including basal ganglia, frontal cortex areas, and thalamus. The combination of an amphetamine challenge and [(11)C]carfentanil PET is a practical and robust method to probe the opioid system in the living human brain.

Currently still riding on 30mg, I have never felt what I am currently feeling on d-amp before, usually this dose exactly give or take as much or as little has me feeling depressed, anxious and irritable, but I am just feeling really chilled, mellow, relaxed, and not tweaked like amps usualyl do I feel good, floaty kind of if I can be honest it feels, kinda like a watered-down version of a threshold MDMA dose, no bullshit believe it or not I am only reporting it because its caught my own curiosity and Im keen to see if others have experienced this. I fidn ti quite wierd due to amps effects on me usually turn me into a like i said depressed aggitated cunt.

I dunno whats going on, but I like where I am at, smooth and content very relaxed, jaw clenching is kicked in too and I feel a bit loved up.

 

[Non Nobis Solum]

Dextro-Methamphetamine may give you an opioid high since it stimulates a ton of dopamine production.. Dextro-Amphetamine doesn't do that so much at all and is mostly norpherpherine and serotonin.

 

[MrSpeedyG]

Dexamp is primarily norepinephrine/dopamine IIRC its a 1:1 affinity for the same, dont quote me though, serotonin isnt affected by regular amp that much but it does affect it (minor) whereas methamps monoamine release ratios are higher for dopamine over norepiniphrine and releases IIRc 3 times more serotonin mg for mg comapred to regular amp.

I have felt this sort of feeling off of low dose methamp before which I as many others can tell you is smooth as shit in low doses, just finding it wierd how I am feeling like this off of d-amp when usually it turns me into a raging agitated fucker lol

 

[MrSpeedyG]

Anyway just an update, the smooth, mellow, bliss over about 2 hours has turned into a regular speed high with plenty of jaw clenching to go with it, which is amazing seeing as my tolerance is pretty dam high

Quite wierd though, but damn it was nice to be so mellowed out yet focussed, literally was nodding off.

Interested to hear if other people have gotten this feeling off d-amp in particular I find it pretty odd

 

[som3dankbudz]

Dexamp is primarily norepinephrine/dopamine IIRC its a 1:1 affinity for the same, dont quote me though, serotonin isnt affected by regular amp that much but it does affect it (minor) whereas methamps monoamine release ratios are higher for dopamine over norepiniphrine and releases IIRc 3 times more serotonin mg for mg comapred to regular amp.

I have felt this sort of feeling off of low dose methamp before which I as many others can tell you is smooth as shit in low doses, just finding it wierd how I am feeling like this off of d-amp when usually it turns me into a raging agitated fucker lol

Yes, I will try to set this straight. I read the original thread on this a month or two back in the ADD. To answer the question, yes endogenous opiates like beta-endorphins are released in the thalamus, nucleus accumbens and another area, cant remember. But we came to the ultimatum that due to dexamp and methamp's potent DA and NE releasing effects, and overall resulting stimulation esp from the NE. Will in most cases far outweigh the psychological, well subjective effects felt from the relatively small, but respectable amount endogenous opiates released.
Evidence supporting this claim, includes how amphetamines, even in therapeutic doses, do for the majority including myself; oddly delay or buy you some time in opiate withdrawal, and even seem to almost eliminate most of the mental symptoms as well as physical dysphoria. I could go on, but you get the point. Also the first 2 hours of dexamp,and methamp I find my pupils are constricted, and I don't doubt that it plays some part in the addiction as well as initial euphoria and mood lift accompanied with the DA and NE release, but it doesn't feel like an opiate due to the "speed" effects, so the more you dose the more the NE will cancel the endorphin buzz, its just simply not an opiate lol. But once more of that lovely motivating DA(dopamine!) gets converted to NE, I find my pupils fully dilate, and I feel speedier.
Another point that's interesting to me, that supports this claim is, has anyone noticed how much lower your opiate tolerance is if you drop a few oxy or hydro's while still high even on the downslide of amps? Without any amps in my system it takes me about 40 mg of hydro to get that great comfort, but with amps i feel the effects of 30 mg much more drastically and intense. A roxi 30 has me feeling right, and i can normally do about 1 and a half to feel absolutly great, but not too much where i'm sick. But 3 hours after 40mg dex-amp the other day, with no change up in opiate use, i did a roxi and a half and was high to the point of nausea, like I did 2 30's. Ive noticed this for awhile, but never got the chance to ask/. this seems like a good thread to ask

PS: When I was little about 9 or 10 I was on adderall sense 5(FUCK THAT WHO GIVES DEX AMP to A 5 YEAR OLD???) by 3rd grade I always complained of side effects so they kept me on like 10mg xr adderall which sometimes had the paradoxical effect of making me fall asleep uncontrollable some days, randomly b/c the dose was so low or something, even at 15mg xr it did that. I do know that stimulants generally even in high doses make me much calmer for the first 2 hours esp high end therapeautic like 30mg dex, and I feel almost so calm I'm tired I dont fidget , and my mind doesnt race and do stupid impulsive stuff. This phenomenon is experienced by many of us with "ADHD" stims at the right dose calm you down, but allow you to be alert enough to maintain focus. You may be experiencing the paradoxical idiosyncratic effect from to small of a dose due to tolerance and maybe abuse? idk you, but thats more likely than the endogenous opiate release taking over, the day you read the study, just saying it may make alot more sense, considering the factor that its not a placebo already. Update me back,take care.

 

[Treefa]

Idk man I've used an adderall/xanax combo to make it to work during opuoid withdrawal and it did provide some relief.

I do notice that opiates tend to wire me up and on amphrtamine I get the 1000 yard stare as with opiates.

Whrn, big when, I experience euphoria from amps it doesn't feel all that different from opiates except it seems to be the opposite as far as psychology effects and more energy.
But the physical feeling itself is not completley different

Ive slept on amps in class also lol

 

[MrSpeedyG]

My bad forgot about this thread!

som3dankbuzz, wish I could answer about why the opiate tolerance seems to be lowered on amphetamine and my only guess would be that amphetamine is defintly affecting the opiate system in some way, possibly that endogenous opiates account for the 10 or so mg that makes the 30mg whilst on amphetamine feel like its 40? I'm not too sure but I am curious to know myself lol

The fact the amphetamine helps opiate withdrawal only reinforces the fact that it does affect the opiate system, however mild it may do so. Have also, as you mentioned Treefa, that the euphoria of amphetamine is similiar to opiate euphoria in the feeling but obviously one stimulated and one not. Have never done opiates and don't plan too for that reason lol.