Amphetamine and CYP450 metabolism

[Lightning-Nl]

my dexedrine dose has been the same for 15 years but even the half life and elimination is faster and I am really hyper and obnoxious at 15. I got an enzyme test that tests that among a few to have on file in case the DEA gets weird. I get tired, mature and calm from them and everything else is too weak for me and I can't eat between doses... There was a PRN pharmacist at the place I go and she was livid and thought I was a druggie... the other one that knew me said to seek out testing in case. We found genome testing but I had to pay 1,167 dollars for it. I have tried other things but except for adderall, the rest were sugar pills.

You didn't make it clear at all what you were referring in this post. Why did you need an enzyme test? Why was your pharmacist livid? and what's up with your Dexedrine?

On paper, yes, some small amount. But I don't think metabolic breakdown of amphetamine via CYP enzymes is very significant. I seem to recall most of it is metabolised by MAO to phenylacetone.

It's been around 4 months since this post, so I've had a lot of time to read up about the pharmacokinetics of Amphetamine. With that being said, I've yet to find a study that really confirms that with any certainty. I also thought this was common knowledge until I tried to find studies that proved it. Do you know of one? I'd love to add it to the Wikipedia article if you do.

I don't see how MAO couldn't play a part in Amphetamines metabolism, however, I can't seem to find any proof that MAO is the main mechanism behind amphetamine's metabolism. All studies only seem to reference CYP3A4, CYP2D6 and FMO.

 

[THE_REAL_OBLIVION]

I know Tagamet (with my 600mg pills) does something to it's duration in any case.