Amphetamine addiction

[Seppi]

I think asking this question outside of wikipedia might give me more useful feedback, and it's right on topic for this subforum, so here it is:

Does anyone think it would be worthwhile/helpful for me to recreate a graphic like the bottom pathway in this KEGG diagram link to explain the signaling cascade in amph addiction and how the different components (e.g., NMDA receptors and delta FosB) relate in that section of the amphetamine article? Or, is that a bit too technical, too much info, etc? It's not mentioned in the section, but delta FosB is downstream from the NMDA receptor in the addiction pathway.

I'd appreciate any thoughts/comments on this, since it takes me 10-20 hours to make (IMO) decent looking neuron schematics/diagrams. I'd rather not spend that kind of time to create a diagram no one finds useful.

 

[Captain.Heroin]

I would find it useful.

 

[BallsStapledToLeg]

Depending on how technical you want to go, perhaps detailing some of the transcriptional changes would be a good way to branch off. I know that delta FOSB as well as several epigenetic factors are activated with higher dose amphetamines in primates. In particular, the NMDA-CREB-NOS pathway seems to be pretty relevant. I'll try and post sources when I'm not on my phone.

 

[Seppi]

That would be helpful since I haven't decided what I want to add beyond that diagram yet. The references I have to use for this need to meet a certain minimum standard though. Basically... for any given medical statement in that article (this includes basically everything but the history and chemistry sections, even the diagrams/schematics), at least one of the references for each statement has to satisfy these pubmed search criteria:
http://www.ncbi.nlm.nih.gov/pubmed/?term=Review[ptyp+AND+"last+5+years"[PDat]+AND+Humans[Mesh]+AND if you follow that link, you'll end up with "Review[ptyp AND "last 5 years"[PDat] AND Humans[Mesh] AND" in the search field. Just add any search terms you want to use after that and it'll search with the required filters.

The policy page for medical article citations is pretty lengthy, but this is the link - https://en.wikipedia.org/wiki/Wikipedia:Identifying_reliable_sources_(medicine)

 

[Dresden]

It might be useful if you made sure to define all the acronyms by their full name and give a short synopsis below each diagram in somewhat plain English wherever possible. Chemical diagrams would also be interesting.

 

[AlphaMethylPhenyl]

From what I understand: yes, that would be helpful. Thanks.