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  • BDD Moderators: Keif’ Richards

Amphetamine (Adderall) and dexmethylphenidate (focalin) question

MeSKAline

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Mar 21, 2012
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Well long story short: This past week i used various stimulants this past week. I already had a large tolerance to stims from this summer in Amsterdam where I would use very pure mdma and speed when I went raving each weekend and heavy cocaine use (around 5 to 6g a week). Now that I have moved to colorado I have kind of calmed down, but I have developed a very strong liking for adderall due to it being cheaper and having a better high than coke (IMHO and I have had some good ass coke). The problem is that recently I used it a few times too often in a row plus at high doses to catch a buzz (usually 70-120) and also used MDA twice (had to test out ghe batch). Two nights ago I tried to use 120mg it as a semi therapeutic tool (I use it sometimes as a creative aid I find it helps my hip hop rhymes) but felt no euphoria at all so half an hour later I took 120 more mg to no extra effect, my heart wasn't even racing. Now of course I know this is due to the fact that I need to take a break. But since my job sometimes requires me to be fully functional in the middle of the night (red eye shift) I need some kind of ergogenic aid so to speak just for when I am super tired.

I tried 100mg of dexmethylphenidate (focalin xr) orally yesterday evening and even though in my benzo induced ragetardation I forgot to crush up the beads I felt thesome stimulation and mood lift, obviously having to rail a few ritalins every now and then to amp it a bit up ( which had a moderate effect although it could have also been psychosomatic) then took two xanax bars then two more which did still not put me to sleep :/

Pretty much my two questions are: 1) do methylphenidate and dexmethylphenidate have a significant cross tolerance with amphetamine? 2) if used responsibly can their effects replace those of amphetamines as needed until my amp tolerance goes down?

Some info bout myself:
19 years old, 145lbs 5'8 lean muscular build, possibly bipolar and tried many many drugs so I will just list the stims: adderall, vyvanse, mda, Ritalin , focalin, cocaine, more cocaine, prophlhexedrine and recently I have heavily abused xanax for sleep reasons (and cos I enjoy being barred out) used a lot of opiates the week before. I have severe depression and possible bipolar.
 
1. Following chronic exposure to d-amphetamine, you will show tolerance to most stimulants including methylphenidate. All three drugs are DRIs, so cross-tolerance does exist and is pretty significant because of how pharmacologically similar they are.

2. More than likely, switching to methylphenidate will allow your tolerance to amphetamine drop a little bit, but since there's such significant cross-tolerance, don't expect it to drop much. If you're using them for ADHD, they won't replace the effects, but they will help. Amphetamine is also a monoamine transporter reverser as well as a DRI which causes a flood of dopamine to enter the synapse, yet methylphenidate is just a DRI, so you might get some efficacy back with a VERY long break from amphetamine.

If you really want to lower your tolerance and don't need them to function, just don't take any stimulants for 2-3 months.
 
What defines chronic exposure though? As i didnt think that only 5 days of indulging (whilst eating n sleeping correctly) would drastically change the way I reacted to amphetamines and analogous compounds for such a long period :/

Also I am not using them for ADHD even though I am pretty sure I have it (never been diagnosed and costs too much without insurance) but i use them exclusively for extra energy/staying awake/creative endeavors. Recreationally I used to prefer amps over even the best coke but I stopped that as well since they didn't work the last time I tried (as previously stated).

Am I doomed to not be able to do double shifts, write my raps and etc for a couple months then? Cos honestly that extra energy is the only cure I have found for my crippling depression...
 
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At least try to cut back on your doses, those are extremely high doses. Taking doses that high even for just a week can really raise your tolerance. Also have you been sleeping and eating properly?
 
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