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amph-saline crystals?

Doctor Abalaba

Bluelighter
Joined
Aug 24, 2008
Messages
46
It is very common in research labs to use amphetamine in 0.9% saline in order to administer to rodents. If the solution is left out, the liquid evaporates and crystal-residue accumulates. It drastically increases in weight (for example: 0.25g->5.0g at 2.5mg/ml). What is going on? Is the residue still amph? What is the behavior of the solution?
 
I did figure I was the salt (salt water + amph = amph salt). I apologize for being vague but I was interested in a) Would it be orally active or is the another, more effective route for the salt (smoking would be effect, correct), and b) Is the drastic increase in weight (.25g->5g) not odd? and lastly c) How can this be undone?
Sorry but I'm not proficient in chemistry, and although I understand some, I'm learning as I need to. So if you guys could humor me a bit, it would be very helpful to my ignorant ass.
Thanks.
 
It'd taste salty, but it'll get you high! All it is is table salt and amphetamine mixed together. You could mix it in water and plug it if you don't wanna eat all that sodium, but I'm not sure what's so confusing about this. The extra .25 grams is sodium chloride - table salt.

Second Hammilton on the lawl.
 
A twenty-fold increase in mass? You'd need to evaporate 422 mL of .9% saline solution to get 4.75 g NaCl.

But if the amphetamine concentration in the saline is 2.5mg/mL, 422 mL would contain 1055 mg of amphetamine, not 250. So then either the residue is not anhydrous or the numbers you put up are wrong.
 
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So the simple answer is the observed 20 fold increase in weight is normal. It is literally table salt and amph.
You guys would make good teachers, laughing at students really helps convey their stupidity. Cheers!
 
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