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Amitriptyline/endep

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misk

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Joined
Jan 6, 2011
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i posted this in the Amitriptyline thread in Other Drugs, but got no response and from what i've heard this is pretty common in aus...

i was given this to help with my depression and anxiety as the doctor thinks my nerve/muscle pain in my legs is due a mental condition rather than accepting its not my head playing tricks on me.
the doctor claims that depression is making me feel the pain in my legs upto 3 times more than if i was happy...
i think hes full of shit to be honest, i've had the same pain even when i was happy and fine mentally for months on end.

he insisted it would help with my anxiety and depression so i wouldn't feel my pain as much and also mentioned it would help me sleep like nothing else.

i asked if the sedation was due to an antihistamine effect a few times and he clearly said no everytime.

so im curious, what causes the sedative effect in this drug?

it would be good to hear others thoughts of other prescribed this in the past...
does it actually help with anxiety and depression at doses of 25-50mg?
how long will it take for any effects of the drug to become noticeable?
 
Yes your doctor is telling the truth on many counts. I've been on this drug and is moderately sedating at the doses you are taking and can also help with nerve pain if that is what you are experiencing. I would ask to be put on nortriptyline if you notice any side effects though because nortriptyline is the active metabolity of amitriptyline and generally has less pronounced side effects. Tricyclic antidepressants generally work quicker than SSRI's and you should feel the effects after a week of using.

Misk no offence mate but you seem to have your mind pretty closed to new ideas. From what I gather (from posts in over the forums) you seem to have the idea that you need strong opiates or similar to help your situation and unless you get them you will be helpless, jobless and in pain. I high recommend you open yourself up to the advice your doctors give you and the treatment they trial. You won't appreciate any of the potential benefits from these treatments if you shut your mind off to them. Please don't take this as criticism, I'm just trying to help.
 
sorry if it comes across that way, after trying random medications time after time its hard to believe a doctor telling me that being happy will reduce the amount of pain i feel.

i dont want opiates, i dont want any of this shit, but at the moment i am jobless, in pain and everytime i leave a Drs appointment i do feel helpless.

if this is some wonder drug that helps me on all accounts, then great!
i'll give it a go like all the others and see what happens.
 
Regarding the histamine receptors; it does have binding affinity for the H1 receptors, atccording to Wikipedia, and for various other sites in the brain that could contribute to it's sedating effects. I don't have access to the full articles, but I might be able to look it up on eMIMS later.
 
ahh i missed the lil H1 on the wiki site lol
which other receptors would cause the sedative effect?
i'm only curious cause i get barely any sedation on a 50mg dose.
 
^ It's sodium, potassium and calcium channel blocking effects; these are all known to cause fatigue at varying rates. It also acts as a muscarinic receptor antagonist which can cause drowsiness.

Some people get the sedation worse then others though; my brother was prescribed this for headaches, and it would knock him out and leave him drooling all over himself in his sleep. Whereas his friend would sometimes take them with codeine at the same dose and be sedated but not to that level.
 
my dog was on this medication to calm him at dog school and it did NOTHING and he was on 100mg ...

Thats my 2 cents :p
 
misk said:
i was given this to help with my depression and anxiety as the doctor thinks my nerve/muscle pain in my legs is due a mental condition rather than accepting its not my head playing tricks on me.
the doctor claims that depression is making me feel the pain in my legs upto 3 times more than if i was happy...
i think hes full of shit to be honest, i've had the same pain even when i was happy and fine mentally for months on end.

he insisted it would help with my anxiety and depression so i wouldn't feel my pain as much and also mentioned it would help me sleep like nothing else.
Click to expand...

There is much evidence that mood has a role modulating pain, he's right there. It's unlikely to be the main reason that a tricyclic like amitriptyline would help though... perhaps it's neuropathic pain.
 
First ever post on this site for me.
I am on 50mg endep at night to help me with nerve pain and to sleep and it works quite well to elevate mood slightly and it's not so potent as to be noticeable as an 'artificial' mood changing chemical imo.
Misk: It's interesting that you say the doctor puts your bicep pain down as being the result of an emotional state of anxiety because I distinctly remember as an angst ridden youth getting these strange pains down the fronts of my legs when in a stressed out, tumultuous emotional state. I'd have to agree with your doctor (in relation to my condition, anyway).
Your doctor must be quite perceptive and astute. Keep one like that!
Formerly, I was taking 3x25mg endep a day and that seemed to alleviate my mood quite well although I now have tropuble sleeping without it and if I take my night time dose and stay up for too long it's like I 'missed the boat' and can no longer get off to sleep very well.
I hope this is useful to you.
 
the only reason i was a bit suss is because they tried me on dothep and it seems like this endep is very similar.
i understand they are different but i noticed nothing on dothep after a month

i'll give it a go for a month or so and see what happens.
 
has anyone experienced any restlessness when taking this medication?
my RLS was extreme last night when trying to sleep
 
I took Endep before.
But in low dose, 10mg twice a day.
My GP explains that, it inhibits reuptake of Serotonin and NA, has antihistaminic action, anticholinergic, it also alpha adrenoceptor which prolongs QT interval in heart.

I do some reading in Medline, that the pain relieving effect isn't bcoz of its inhibitory of catecholamines reuptake. It's something else.

But many GP co prescribe opiates with Endep to potentiate the analgesic effect.
(Just make sure the opiate isn't codeine or Tramadol,as Endep blocks the transformation into the active metabolites.
Both codeine and tramadol are pro drug. ).

Prothiaden( Dothiepin) is a thio-analogue of Amitrityline. It has more anxiolytic effect.
 
thanks for the reply guys, i'm a bit shitty my Dr didn't take the time to discuss dosage size and times with me as i have no idea which would suit me best.

antihistamines have little to no effect on me, and from what i've read the analgesic properties are only relevant at 10mg doses.
so i'm not sure if i should be taking a higher dose to help with depression, or a lower dose to try and help with sleep and pain.

i'll have a chat with him and see what he says.
 
Have you tried Mersyndol?
(Not Mersyndol Daystrength).
It has analgesic and calmative action, for moderate to severe pain. I find it very useful.
It has
450mg Paracetamol
9.6mg Codeine
5mg Doxylamine

If this is too sedating, then try Fiorinal Dental which contains only 2mg of Doxylamine as calmative. With this I can take 2tabs with good effect,feeling calm,with painkilling effect.

As for me, even 2tabs of Restavit/Dozile ( Doxylamine) 50mg still keeps me awake. So Mersyndol only calms me down, useful for tension headache and general pain.
 
Just be sure not to take larger doses to achieve more effects, tricyclics are very dangerous drugs to overdose on - they are known to cause fatal arrythmias and likely responsible for a large percentage of succesfull suicide attempts via intentional overdose.
 
fuck this shit is horrible for me!
on a 50mg dose (started on 25mg and was no different) have had side effects like increased heart rate and blood pressure, trouble staying asleep (more than usual), extreme dry mouth, increased anxiety, frequent muscle twitches...

did nothing to help with the pain, anxiety or depression.
i'll try half a 25mg tablet and see if anything changes.
the Dr had nothing to say other than 'keep trying', i brought up the different effects at different doses and he didn't seem to know what i was on about.

edit - how quickly can i lower the dose?
i kind of feel like i get withdrawals from it by about 4pm as i dose the night before, feels like shit, so i want to try and avoid withdrawals if possible.
 
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Just be aware that amitriptyline combined with morphine is the assisted suicide combination recommended and prescribed by a semi-infamous Dr in Cairns (now deregistered).

I don't know how the combination works, but the Dr hinted to this friend of a friend who was in a car accident many years ago & has multiple health problems, that if he were to accidentally take too much of that combination that he would die a peaceful death.

I know amitriptyline will cause a heart attack if you take too many, so I wonder if it's as simple as that. amitriptyline causes the heart attack, & the morphine dulls the pain..

EDIT. Sabotka has already addressed this point.

err. my mistake. I thought endep was a brand of morphine. boy is my face red.
 
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