Jabberwocky
Frumious Bandersnatch
So this combo apparently reduces both tolerance and withdrawal symptoms from morphine in rats.
Very interesting.
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N&PD Moderators: Skorpio
Amitriptyline and magnesium sulfate reduces both opiate tolerance and withdrawal
- Thread starter Jabberwocky
- Start date
So this combo apparently reduces both tolerance and withdrawal symptoms from morphine in rats.
Very interesting. 
Xorkoth
Bluelight Crew
Very interesting indeed. It would be good to have a non-addictive method of making opiate withdrawal easier to get through. Also I wonder if tolerance reduction applies to the perma-tolerance that you get after abusing opiates heavily? Even when I took a 5 year break of absolutely no opiates, when I relapsed, my baseline tolerance was still way higher than it ever was before the abuse.
4meSM
Bluelighter
Yeah that's kinda what I thought. Plus they're giving them magnesium sulfate via injection (intraperitoneal). I don't think this translates very well to humans, but I could be wrong.
I'd rather take a more bioavailable form of magnesium though (like magnesium glycinate).
plumbus-nine
Bluelighter
Does magnesium work as a NMDA antagonist in humans too if you just take enough? So there should be a dose window where you'd get intoxicated/dissociated before hitting real toxicity? Any hints of this dose window? (Don't worry, I don't intend to try it anytime soon, atm memantine is good enough
but I never got any results from magnesium..)
Interesting, but nothing new about amitriptyline. Even fluoxetine can potentiate morphine analgesia and possibly delay tolerance a bit (need to find the source again). Venlafaxine strongly interacts with opioids as I had to find out the hard way, one indeed feels less withdrawal from them but somehow taking opioid + venlafaxine together for some time reinforces dependency on the latter..
