Amisulpride and Psychedelics/empathogens

[Mitchi]

Hi

Will a dose of 50 mg. pr. day of Amisulpride have an effect on the drugs, Mescaline and MDMA? Will it null the effects of these two drugs, or could it function?

Links to the pharmacology of Amisulpride: http://en.wikipedia.org/wiki/Amisulpride#Pharmacology and http://www.biopsychiatry.com/amisulpride.html

Thanks in advance people

 

[Thorns Have Roses]

APs are generally gonna have an effect on your trip, that being a dampening of desirable effects. 50mg seems to be on the low end for this one, so hopefully this won't happen and you'll be able to work around it.

 

[alovesupreme]

consuming antipsychotics and/or benzodiazepines prior to taking a psychedelic drug will most certainly null out the effects of the psychedelic almost completely. that said, if you are being prescribed antipsychotic medication, i'm not sure that you should really be taking hallucinogens...

 

[Dmytry]

shouldnt have too much of an effect on the mescaline, because amisulpride is a dopamine antagonist and mescaline works on serotonin. but it will destroy your attempt to roll as mdma releases quite a bit of dopamine. either way, if you have to take an antipsychotic you shouldnt be messing with psychedelic drugs in the first place

 

[Mitchi]

It sounds like the psychedelics will work. The person who took truffles with Amisulpride, also took a very low dose of truffles, only 10 grams which is equal to something like 1 gram of cubes (if the truffles were fresh, that is. Id better send the guy a PM
I'm still curious about the MDMA. As long as it's only dopamine that are affected, it might work out. I mean, it's serotonin that gives you the empathy, off course there will be a lack of "something" (maybe just the jaw tension?)

I guess the most important thing is that there is no health risks, or physical risks, at least

 

[Survived Abortion]

^It doesn't really work like that. The interactions between the various neurotransmitter systems are inextricable. It's not just gonna be a lack of jaw tension, the entire experience will be affected such that it won't even feel like the same drug.

You have to remember, it's not just the primary actions of the drug molecule which elicit the experience, it's the biofeedback which you engage in which makes it what it is. A drug experience is something you are doing/being, rather than something that just happens to you via molecules bouncing off receptors in your brain. So for example, if you can't activate your own reward system in response to various processes which happen as a result of the experience, you are missing out on a huge chunk of what it's about.

Why are you taking that stuff? It's horrible and very harmful to your precious brain. Don't listen to the "if you're taking antipsychotics you shouldn't be messing with psychedelics" crap which always gets doled out every time someone asks this question. Antipsychotics are pure garbage drugs handed out by idiot quacks who care about nothing but $$$ and the rulebook, and just who are they to decide what is mentally "ill" or "healthy" and what drugs you should and should not take. Go ahead and take your psychedelics. But please consider chucking that antipsychotic trash in the bin and treating your so-called "mental illness" not as an illness but as a spiritual crisis, and follow it through as such.