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Amdipt, Mdmamt, Mamt,

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hamhurricane

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I have seen some reports on AMDIPT (all of which were written in the 90s) it seems like an interesting substitution and one which was not explored in other obvious analogs (e.g. AMDMT) and I'm guessing due to limited availability it was not tested by many psychonauts. This got me thinking, given the extreme similarity between AMT and amphetamine, is there a reason why AMT was not used by Shulgin and others psychedelic chemists to convert various successful amphetamines into tryptamines? aside from the possibility it might decrease potency a bit. Things that come to mind would be Methylenedioxyalphamethyltryptamine (MDAMT) and MDMAMT, MAMT, 4-fluoro-AMT etc. etc. etc. Is this a chemical impossibility?

EDIT: I just did a search on AMDiPT and Jamshyd referred to it as 'mythological' was this this substance proven to be non-existent at some point?
 
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I guess AMDiPT means alpha-methyl-DiPT?

is there really so much similarity between AMT and amphetamine? are there any similarities in the physiological action, or do simply refer to the structural analogy of the side chain?
 
ungelesene_bettlek said:
I guess AMDiPT means alpha-methyl-DiPT?

is there really so much similarity between AMT and amphetamine? are there any similarities in the physiological action, or do simply refer to the structural analogy of the side chain?
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you know as much as i do about AMDiPT...

AMT: Alpha-methyl-tryptamine
Amphetamine: Alpha-methyl-phenethylamine
physiologically the have distinct differences; amphetamine has a largely dopaminergic activity while AMT seems to have largely serotonergic activity, AMT lasts longer but may require a higher dose? And the most obvious difference...one is psychedelic and the other isent.
 
You can't expect that by created alpha-methyl Tryptamine analogues of PEAs you're going to get anything similar to the original PEAs.

It'd be really interesting to see how they'd fare, though. I mean, AMT is a very benign psychedelic- not prone to horrible anxiety like other tryptamines are.

They could be interesting drugs, but they're not going to be much like the originals you're attempting to re-create.
 
I referred to that erowid report as "mythological" because as far as I know, the author seems to have obtained it out of the blue. Although I never spoke to him personally, everyone seems to agree that this person has an elitist attitude and it is not unlikely that he lied just to seem special. No one in the whole world, not even shulgin (If I'm not mistaken), seems to have ever seen that substance before.

Other than Murple, that is.

As for AMT, I would put it up there with LSD and DPT. Wonderous stuff... it has all MDMA has to offer, and none of the bad effects, and much more icing on the cake!
 
Even alpha,N-DMT is much less active than AMT, and doesn't sound great, see tihkal #8. alpha,N,N-trialkyltryptamines are pretty likely to be inactive i think. Ring substitution of AMT (not 5-MeO) might have a chance of producing a decent psychedelic.

Lycaeum has these trip reports, sounds like probably placebo:

http://leda.lycaeum.org/?ID=356

I wouldn't be suprised if some people had tried it, its one step from DIPT.

Never noticed this before, under AMT:
And there are five possible chain relocation, from the normal 3-position to the 2, the 4, the 5, the 6 or the 7-positions. All five "alpha-methyltryptamine" isomers are known, but only one is known to be active in man as a CNS active material. This is the 5-isomer, 5-(2-aminopropyl)indole or 5-IT, which, at 20 milligrams orally, is a long-lived stimulant producing increased heart-rate, anorexia, diuresis, and slight hyperthermia for about twelve hours.
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Looks like an MDA analog, though i think with MDA the heteroatom is better meta to the isopropylamine. Does anyone have any data on 4-aminoamphetamines? 4-dimethylamino-2-methylamphetamine is apparently an MAOI that acts selectively in monoaminergic neurons:

paper
 
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aMT is like E without the energy or euphoria, I would suspect 5meo/aMMiPT to be better than aMDiPT cuz I dont like anything that has DIPT or DPT in it. I think molecules are better and for some reason less susceptible to MAO when they're uneven like MiPT,MET,MALT... altho no matter what, potency aside I still think nothing tops DMT tho, altho it looses it's magic if u do it too much which I think alot of synthetics dont do on the otherhand
 
yeah, i found it boring,weak, and made me feel wierd or off, not great like miprocin. ethycin was interesting but still lacked the magic that I've only seen in 4-ho-mipt/met/dmt
 
You didn't take very much did you? At 50-100mg it's absolutely incredible. Better than any psychedelic I've ever had.

That said, at more 'normal' doses (18-30mg), for most people it's not very visual, but it produces a headstate that's really conducive to psychotherapy or other self-exploration. It makes meditation orgasmic.

If you're looking for a psychedelic that's visually pretty, or a party-psychedelic, you're definitely not going to like it.

I don't take psychedelics for that purpose though. I take them to help me work out various problems, give clarity, and to enhance my daily meditation.

EDIT: I should add that I had a friend take 150mg over an hour or so and had the most incredible night of his life. He had always been a bit of an LSD and Mescaline-only elitist; though he used mushrooms, DMT and a few other R/C psychedelics, LSD and Mescaline (as peyote, I should state) were the only psychedelics he continued to use over the years, the rc's were one-time things but shrooms and DMT were fairly regular until the 90s. Where was I going with this? Oh yeah, he's got more psychedelic experiences than me about 70x over, that's it.

Anyway, since that trip, it's the only psychedelic he uses.
 
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damn, 100mg! I cant even imagin taking that much miprocin. I'm def a party psychedelic person. There isn't a single narcotic out there that I like unless it's to add to my psychedelic mix
 
Well, this is Iprocin, but it's a very high dose. Surprisingly, I've never felt any sort of hangover or physical side effect. It seems extremely benign; though the dose-response curve is quite steep, after the 50mg mark, it seems to level off a bit.

As I'm sure you're aware, it's primarily a mental psychedelic, not a pretty visual one, but it doesn't seem prone to inducing anxiety and freak-outs.
 
be careful with 4-ho-dipt doses above the 50mg mark. I spent an extremely unpleasant several hours from too much stupidity (among other things) and 4-aco-dipt. I know they are not the same substance (after comparing 4-ho tryps with their acetyl counterparts, I dont really buy the in-vitro 4-ho > 4-aco hypothesis)

Trip report>http://www.erowid.org/experiences/exp.php?ID=60403
 
toxide said:
yeah, i found it boring,weak, and made me feel wierd or off, not great like miprocin. ethycin was interesting but still lacked the magic that I've only seen in 4-ho-mipt/met/dmt
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4-hydroxy-N,N-diethyltryptamine had a special talent for bringing my anxieties into the spotlight (but then the only tryptamines I get on with are the non-ring substituted ones (AMT, DMT, DPT etc) - possibly due to some horrendus liberty cap abuse in my 20's, anything remotely psilocybin like carries too much self imposed psychological baggage for me these days
 
This thread got seriously derailed! Do any other knowledgeable people have anything to say about AMDiPT, the more i think about it the more AMDMT seems impossible (alphamethyl-dimethyltryptamine?)

Ham-milton said:
You can't expect that by created alpha-methyl Tryptamine analogues of PEAs you're going to get anything similar to the original PEAs.

It'd be really interesting to see how they'd fare, though. I mean, AMT is a very benign psychedelic- not prone to horrible anxiety like other tryptamines are.

They could be interesting drugs, but they're not going to be much like the originals you're attempting to re-create.
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yes yes yes that the whole point, i think they would yield interesting new substances!
can anyone speculate about their activity?
 
The molecule isn't impossible, it's just that it;s so 'cluttered' around the side chain that it's too big to fit in the receptor (steric hinderance).

Everyone here could speculate about activity, but whether that was correct or not is a different matter!
 
^ when it comes to sterics is it better for the groups to be in the equatorial position than axial for certain receptors, or is that only when chair conformations are present? (im not one for pharmacology)
 
i believe this was asked before in another thread but with no final answer, but what about 3,4,5-thrimethoxytryptamine? i guess it seems as if these phen to trypt switches wont have any activity although Tihkal reports on some MDO tryptamines that sound fascinating!
 
dorothyperkins said:
Equatorial/axial only applies to rings
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i know, sorry my question was sorta off topic. i was just curious how either position affects receptor affinity, and if equatorial usually 'fits' better into certain receptors because of less steric hindrance...
 
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