I'd say a huge portion of the drug users on here (which is a huge portion of the people on here) would say this is true.
I get anxious when thinking about my next fix. My nose starts to drip, I can taste it in the back of my throat, I imagine each step until my mind won't allow me to continue to taunt myself and I cave and get messed up (again and again). I almost feel more high before I get high. After? Nothing at all, seemingly.