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am i one of those unlucky people ? and could it actually do any harm ?

flyhighk

flyhighk

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Apr 26, 2013
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I took ~100mg of codeine on an emply stomach, and waited. 20 minutes later, i felt warm, nauseous and slightly euphoric. So i just laid in bed. My scalp was quite itchy. And the nausea would come and go. But the effects were quite pleasant. An hour and a half later most of the effects were gone, but the nausea and itchiness. Those lasted a few hours.
6 days later, i took 180mg of codeine right after waking up, with 50mg of hydroxyzine and diet soda. I expected effects much more intense then last time. When it kicked in 30 minutes later, i felt happy, but no as much as last time. And i was sedated so an hour and a half later i fell asleep. This time, no nausea or itching. But milder euphoria. It was barely noticeable.
I had expected much better effects, especially because of the hydroxyzine.
Did i build tolerance that quickly, or am i a poor metabolizer ? Could the diet soda have something to do with it ?
These were my first times experimenting with opiates/opioids. I used sulfate the first time, and sulfate hemihydrate the second time. But i guess that doesnt mean shit. And are poor metabolizers harmed by codeine ?
Thanks
 
I pulled this off another thread. Hope it helps

The body converts codeine into morphine (~10 by using the so called P450 cytochrome pathway, especially cytochrome 2d6 (cyp2d6). Unfortunately, cyp2d6 is missing in about 7% of the white population, and its manifestation is quite variable in the rest. Individuals who inherited a cyp2d6 deficiency will get many of the adverse effects associated with codeine but little euphoria. If codeine just doesn't work for you, this may be why.
Some drugs also interfere with cyp2d6. Prime among these are the SSRIs, with the exception of Zoloft (if I remember correctly). The most potent inhibitor is paroxetine (paxil), followed by fluoxetine (prozac). If you are taking an SSRI, you will probably experience a markedly decreased euphoria when using codeine. (Paxil has a half life of only 24hrs, so not taking it for a few days will do miracles; the half life of prozac is 7 days.)
Finally, codeine itself is a cyp2d6 inhibitor. This means that taking the whole dose as quickly as possible will probably give you the biggest high (ie. its a waste to redose in 30 mins).
 
Could be anything stomach content, caffiene, diet, poor metabolizer. I dont think you will be hurting yourself as long as you keep the dosage reasonable
 
What comes to my mind is you didn't give yourself enough of a break between doses.
Next time wait a day or two to get the desired effects.
 
How come no one said "it's because you took hydroxyzine, an ANTIHISTAMINE"

I mean, cmon, it's very obvious. It should have been obvious to you too OP.

and to T. Calderone, he said 6 days...
 
SDforever420 said:
I pulled this off another thread. Hope it helps

The body converts codeine into morphine (~10 by using the so called P450 cytochrome pathway, especially cytochrome 2d6 (cyp2d6). Unfortunately, cyp2d6 is missing in about 7% of the white population, and its manifestation is quite variable in the rest. Individuals who inherited a cyp2d6 deficiency will get many of the adverse effects associated with codeine but little euphoria. If codeine just doesn't work for you, this may be why.
Some drugs also interfere with cyp2d6. Prime among these are the SSRIs, with the exception of Zoloft (if I remember correctly). The most potent inhibitor is paroxetine (paxil), followed by fluoxetine (prozac). If you are taking an SSRI, you will probably experience a markedly decreased euphoria when using codeine. (Paxil has a half life of only 24hrs, so not taking it for a few days will do miracles; the half life of prozac is 7 days.)
Finally, codeine itself is a cyp2d6 inhibitor. This means that taking the whole dose as quickly as possible will probably give you the biggest high (ie. its a waste to redose in 30 mins).
Click to expand...

I had already read the same thread, but thanks
 
bloodshed344 said:
How come no one said "it's because you took hydroxyzine, an ANTIHISTAMINE"

I mean, cmon, it's very obvious. It should have been obvious to you too OP.
Click to expand...

From what I've read, hydroxyzine potentiates opiates. IK it made the nausea and itching disappear, but it should've increased other effects.
 
Antihistamines make you sleepy, man. That's why the effects felt markedly different to you, the addition of another drug completely changed the effects profile. Make sense to you?
 
Well next time I'll do it without the hydroxyzine and I'll see if the euphoria is better. But I'll have to be itchy and nauseous all the time.
And even if I was sleepy/sedated, shouldn't I be able to feel the euphoria ?
Thanks again
 
Codeine does almost nothing to me except give me unpleasant side effects, so it is possible for it to cause you adverse effects even if you're not getting high off it. It might even be possible to OD or do organ damage without getting very high. However, I'm thinking for you it's more likely that it just didn't work well for you that one time (most likely culprit being that you took it with hydroxyzine) since you said it worked before, so I would not jack up your dose next time just because you didn't feel much this time. I'd try it without the hydroxyzine next time. Hydroxyzine does not potentiate ALL opioids, it can lessen the effects of codeine.

EDIT: To explain further, codeine is changed into morphine by the enzyme CYP2D6. Hydroxyzine inhibits CYP2D6, meaning it lessens the activity of CYP2D6, which can make less of the codeine convert to morphine.
 
Last edited:
hydroxyzine is a cyp2d6 inhibitor AFAIK, and as such will prevent the conversion of codeine to morphine, likely explaining why you had different effects. Hydroxyzine will potentiate opiates that aren't pro drugs really well though. If you want to use an anti histamine just try diphenhydramine as it's not a serious cyp2d6 inhibitor, i'm not sure how much stronger hydroxyzine is as one but i know it's killed a lot of different highs for me so i don't mix it with most drugs.
 
To explain further, codeine is changed into morphine by the enzyme CYP2D6. Hydroxyzine inhibits CYP2D6, meaning it lessens the activity of CYP2D6, which can make less of the codeine convert to morphine.
Click to expand...
hydroxyzine is a cyp2d6 inhibitor AFAIK, and as such will prevent the conversion of codeine to morphine, likely explaining why you had different effects.
Click to expand...

I wasn't aware of this, now it all makes sense.
 
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