theukscientist
Greenlighter
- Joined
- Feb 10, 2015
- Messages
- 8
After experiencing the remarkable sedative actions of chloral hydrate (2,2,2-Trichloroacetaldehyde), alpha-chloralose, alpha-bromalose and Chloretone, I was thinking this:
If chlorinated derivatives of acetaldehyde, ethanol, and 2-methyl-2-propanol are more potent and effective CNS depressants than their non-halogenated parent compounds, and the brominated derivative of alpha-chloralose (called alpha-bromalose) is more potent than it's chlorinated parent compound, then why has nobody picked up on the structural-activity relationships of substituting halogens with other halogens? Would the brominated derivative of Chloral Hydrate be more potent than its parent compound, and if so, could it have a use in modern times? I suspect the reason none of these compounds are investigated is because they're related to the 'old-school' sedatives which are no longer prescribed, but why shouldn't we dig up an old molecule, alter it and see what it does? :D Not only could brominated derivatives of Chloral Hydrate, Chloretone, trichloroethanol etc. be tested but maybe science will one day produce analogues of these compounds where pseudohalogens are substituted for chlorine or hydrogen atoms, some very weird and probably dangerous compounds could then be produced imo! Please give your thoughts, comments, questions etc. :D
If chlorinated derivatives of acetaldehyde, ethanol, and 2-methyl-2-propanol are more potent and effective CNS depressants than their non-halogenated parent compounds, and the brominated derivative of alpha-chloralose (called alpha-bromalose) is more potent than it's chlorinated parent compound, then why has nobody picked up on the structural-activity relationships of substituting halogens with other halogens? Would the brominated derivative of Chloral Hydrate be more potent than its parent compound, and if so, could it have a use in modern times? I suspect the reason none of these compounds are investigated is because they're related to the 'old-school' sedatives which are no longer prescribed, but why shouldn't we dig up an old molecule, alter it and see what it does? :D Not only could brominated derivatives of Chloral Hydrate, Chloretone, trichloroethanol etc. be tested but maybe science will one day produce analogues of these compounds where pseudohalogens are substituted for chlorine or hydrogen atoms, some very weird and probably dangerous compounds could then be produced imo! Please give your thoughts, comments, questions etc. :D
