Alprazolam and Itraconazole synergy

[thoughts_of_a_teen...]

Can I combine Alprazolam with Itraconazole to increase the duration of effect?

 

[shreddedlettuce]

Pasting this from Martindale "Martindale-The-Complete-Drug-Reference-36th-Edition" regarding your query.

Itraconazole (BAN, USAN, rINN) Itraconazol; Itraconazolum; Itrakonatsoli; Itrakonazol; Itrakonazolas; Oriconazole; R-51211. (±)-2-sec-Butyl-4-[4-(4-{4-[(2R*,4S*)2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-ylmethoxy]phenyl}-piperazin-1-yl)phenyl]-2,4-dihydro1,2,4-triazol-3-one. Итраконазол C35H38Cl2N8O4 = 705.6. CAS — 84625-61-6. ATC — J02AC02. ATC Vet — QJ02AC02

Interactions
Enzyme-inducing drugs such as carbamazepine, isoni
azid, nevirapine, phenobarbital, phenytoin, rifabutin,
or rifampicin may decrease plasma concentrations of
itraconazole sufficiently to reduce its effectiveness.
Conversely, enzyme inhibitors such as clarithromycin,
erythromycin, HIV-protease inhibitors, including
ritonavir-boosted HIV-protease inhibitors, may in
crease plasma concentrations of itraconazole. Use of
drugs that reduce stomach acidity, such as antimus
carinics, antacids, proton pump inhibitors, and hista
mine H2-receptor antagonists, may reduce the absorp
tion of itraconazole. Like other triazole antifungals,
itraconazole is a potent inhibitor of the cytochrome
P450 isoenzyme CYP3A4, and may increase plasma
concentrations of other drugs reliant upon it for their
metabolism. This increases the risk of adverse effects
and such combinations should be given with caution
and careful monitoring, if at all. Drugs so affected may
include:
• antiarrhythmics such as dofetilide and quinidine
• antiepileptics such as carbamazepine (which in turn
decreases the concentration of the antifungal, see
above)
• antihistamines such as astemizole and terfenadine
• the antimycobacterial rifabutin (which again also
decreases antifungal concentrations)
• antineoplastics such as busulfan, docetaxel, and the
vinca alkaloids
• antipsychotics such as pimozide and sertindole
• anxiolytics and sedatives such as buspirone
• benzodiazepines such as alprazolam, diazepam, mi
dazolam, and triazolam
• calcium channel blockers such as verapamil, and the
dihydropyridines felodipine, nifedipine, and nisol
dipine (see also below)
• cardiac glycosides such as digoxin
•some corticosteroids such as budesonide, dexameth
asone, fluticasone and methylprednisolone
• the coumarin anticoagulant warfarin
• ergot alkaloids such as dihydroergotamine, er
gometrine, ergotamine, and methylergometrine
• the gastrointestinal prokinetic cisapride
• HIV-protease inhibitors such as indinavir, ritonavir,
and saquinavir (concentrations of the antifungal may
be increased in turn by indinavir, ritonavir, or co-for
mulated lopinavir-ritonavir, but not by saquinavir)
• immunosuppressants such as ciclosporin, sirolimus,
and tacrolimus
• opioids such as alfentanil and levacetylmethadol
•some oral hypoglycaemics
• the phosphodiesterase inhibitors sildenafil and var
denafil
• statins (HMG Co-A reductase inhibitors) such as
atorvastatin, lovastatin, and simvastatin