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Alkalinzing Agents and Amphetamine

oh god so advanced...

yes, amphetamine breaks down quickly in acids. neutralizing the acid will increase bioavailability.
 
Tomer said:
UTFSE. This has been discussed a million times.
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Not to be annoying, but I tried to use the search engine and didn't find anything. For future reference, could you give me an example of what to type in the search engine to find what I'm looking for about acidity, and the thread? Thanks :)
Also, sorry if this wasn't very advanced, mods you can move this somewhere else.
 
something alone the lines of, "Potentiating Adderall, or, Enhancing Adderall Effects". Anything along those lines will give you pages filled with ways of maximizing your Adderall use. Which of course include alkalizing agents, tums, rolaids, baking soda, etc. GL
 
No need to flame the guy...

I think the bioavailability is increased because a larger amount of the substance is transformed into the free base, which is taken up into the blood stream by diffusion through the gastrointestinal mucosa...

No personal experience on my side. I prefer the intranasal route...

- Murphy
 
MurphyClox said:
No need to flame the guy...
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+1
I think the bioavailability is increased because a larger amount of the substance is transformed into the free base, which is taken up into the blood stream by diffusion through the gastrointestinal mucosa...
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isn't it because it results in slightly higher blood pH which hinders renal elimination?
No personal experience on my side. I prefer the intranasal route...
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same here
 
^If a higher blood pH hinders renal elimination, shouldn't it increase bioavailability then?
 
Yes.
However yes increased alkalinity will decrease renal elimination, no matter what route you used the amphetamine in (intranasal, say). Most people think of bioavaliability as when the drug is first absorbed, so to use it in a more general sense can be confusing - or from what i'm seeing here anyway.
I'm not certain that stomach alkalinity (or decreased acidity, anyway) has a significant effect in increasing the fraction or rate of oral amphetamine absorption & bioavailability, though it does seem plausible I guess.
 
Wouldn't calcium antacids actually increase amphetamine tolerance? More calcium than magnesium in channels = toxic to neurons?
 
I don't think the freebasing in vivo theory is plausible, at least not without taking absolutely huge doses of antacids, after all, it IS a bag of HCl more or less, in there.
 
Yes, that would work, though you will be ingesting a whole heap of sodium (ions) if you do that.
 
SpunkySkunk347 said:
Wouldn't calcium antacids actually increase amphetamine tolerance? More calcium than magnesium in channels = toxic to neurons?
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what kind of channel do you mean? i guess it's the nmda receptor. if so then more ca2+ shouldn't have effects on that. it's a calcium (+natrium +potassium) channel after all. when opened the calcium will flow from outside the cell into the cell. it's just that magnesium will stick to the channel and hinder the flow of ions thus modulating its activity.
 
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