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  • BDD Moderators: Keif’ Richards

Alcohol derivative of valproic acid

Neuroprotection

Bluelighter
Joined
Apr 18, 2015
Messages
1,265
The anticonvulsant valproic acid is widely used as treatment for epilepsy and in some cases for bipolar dissorder.
I have a question and hope someone with a knowledge of chemistary could help me find the answer.
Since valproic acid is a carboxilic acid (C8H16O2), what product would be obtained by reducing it to the alcohol? I guess it would be some isomer of octanol but I am not sure.
What pharmacological properties if any, do you think this alcohol would have?
 
Oh man am I rusty in naming compounds... Pretty sure it would be something like 2-propylpentanol (you name by the longest hydrocarbon chain since thats 5 its "pentane") however, removing the acid will remove its ability to form salts. I am pretty sure long chain hydrocarbons with an alcohol functional group are at least slightly better for the body because they have a metabolic point in the alcohol group but my guess is it will just get you "drunk maybe" but have a lot of ill effects.

Normally I would close something like this because of synthesis question but this is a bit different. The aldehyde derivative has been studied as a prodrug apparently: http://www.ncbi.nlm.nih.gov/pubmed/2573494
 
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