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Alcohol and Nausea

Tsukasa

Tsukasa

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Joined
Sep 21, 2007
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So last night I had a little too much to drink and ended up vomiting like always and still have nausea today. It may be just because I have a weak stomach, but I was wondering about the mechanism of alcohol's nausea inducing effect. Could it possibly be via 5-HT3? maybe nicotinic acetylcholine receptors or dopamine? Would it be safe to try combining Zofran with alcohol as a preventative measure? I had a couple hits of sour diesel that night but it just makes me dizzy and worsens the nausea. So cannabis doesn't seem to be very helpful. Other anti-emetics would increase the drowsiness and make me pass out too fast so that's also out. Any suggestions?
 
I smoked one al capone cigarillo that night, and yea I'm still on tramadol. Taking much more than my usual dose, since I recently took a break from kratom. I also ate a bag of habenero doritos which might have contributed, and also gave me flaming vomit xD but at least i wasn't drinking on an empty stomache. Though now I just remembered that I was drinking ale and shots of liquor (with cream soda as chaser) simultaneously. Is "liquor before beer, you're in the clear. beer before liquor you'll just get sicker" true or just a myth?
 
tramadol and alcohol always gave me terrible nausea and tobacco made it far worse. i haven't been sick on alcohol in years and i no longer smoke but can drink huge amounts- there is definitely a connection

"Nicotine stimulates the nicotinic acetylcholine receptors and from this you get a cascade down to the dopaminergic system via the noradrenergic. Not as direct as say amphetamine, but in the end, receptors of the acetylcholine system sensitive to nicotine eventually lead to the release of dopamine where it lights up the brain's reward system.

The only thing is, using this system as the target for drugs also sees dopamine released in places most people would rather not have it go, like the CTZ, which controls vomiting; nicotine also causes a rise in dopamine levels there, which is why people usually get nauseous after their 1st cigarette.

I think the designation of the receptor that nicotine acts at is something like a3b4 "

the above in quotes is a post by fast and bulbous from the nicotine stimulant thread in add


as for it being the order in which you had your drinks my answer is nahhhh its the combo of tram alcohol and nicotine as i have done it before and never felt so sick all night and all the next day- it was shatpank

also of note trams on their own (opiates as a rule) never make me sick
 
pofacedhoe said:
tramadol and alcohol always gave me terrible nausea and tobacco made it far worse. i haven't been sick on alcohol in years and i no longer smoke but can drink huge amounts- there is definitely a connection

"Nicotine stimulates the nicotinic acetylcholine receptors and from this you get a cascade down to the dopaminergic system via the noradrenergic. Not as direct as say amphetamine, but in the end, receptors of the acetylcholine system sensitive to nicotine eventually lead to the release of dopamine where it lights up the brain's reward system.

The only thing is, using this system as the target for drugs also sees dopamine released in places most people would rather not have it go, like the CTZ, which controls vomiting; nicotine also causes a rise in dopamine levels there, which is why people usually get nauseous after their 1st cigarette.

I think the designation of the receptor that nicotine acts at is something like a3b4 "

the above in quotes is a post by fast and bulbous from the nicotine stimulant thread in add


as for it being the order in which you had your drinks my answer is nahhhh its the combo of tram alcohol and nicotine as i have done it before and never felt so sick all night and all the next day- it was shatpank

also of note trams on their own (opiates as a rule) never make me sick
Click to expand...

I see. So you're saying it was just a bad interaction? I should note I have tolerance for tobacco, but absolutely none for alcohol. Thing is, I don't know what my limits are. I rarely drink, so I don't know how much I can handle and I guess I'm mentally adjusted to drinking as much as I could a few years ago, when I drank more frequently. In my case the alcohol and my weak stomach might be the main culprit.

I know what fastandbulbous means. When I was just starting to experiment with tobacco, I would get sick and vomit after smoking only a quarter (sometimes less) of an ultra-light cigarette. I know nicotine poisoning all too well. But one of my drinking buddies who smokes ONLY when he's drinking chainsmoked through nearly an entire pack in like 30 minutes tops. It could be he just has a natural resistance to nausea (or tobacco) because I've never seen him vomit and I've known him for years.

Me on the other hand have a natural proclivity to nausea. Whenever I'm hungover nausea is my main symptom. Others I know only get a headache but no queeziness whatsoever. I seem to have resistance to headaches, it's extremely rare that I get one. One time I went through a phase where almost anything I consumed made me nauseas. I don't remember my exact circumstances clearly, but I'm sure I wasn't obviously sick. So I wonder what's the deal with my neuro-chemistry (def not genetics) that makes me so prone to nausea. Perhaps I'll save it for another thread.

As for tramadol, I was afraid I would have a bad interaction. For one, mixing alcohol and opioids increase respiratory depression. Second, tramadol increases stimulation of 5-HT3, which is further potentiated by alcohol. And third, the dopamine... though not sure if it's released in a bad place like the nicotine would do.
 
trams and alcohol alone make me sick the nicotine just makes overload

funny though alcohol and poppy pods doesnt really seem that much different to me than alcohol alone, it must be the serotonin action
 
Alcohol is somewhat unique among GABAnergics in changing the density in the fluid of your inner ear, often inducing nausea, as felt acceleration fails to match visual input. Clearly, other nauseating agents will synergize with this effect.

ebola
 
ebola? said:
Alcohol is somewhat unique among GABAnergics in changing the density in the fluid of your inner ear, often inducing nausea, as felt acceleration fails to match visual input.
Click to expand...

very interesting. 1st I've heard of this. Apparently you also do not need to be moving for the changing density to have an impact because there is a pressure gradient outside and inside the labyrinth. Alcoholic blood is less dense than normal blood, so the lymph inside the labyrinth is relatively dense. Then as alcohol diffuses into the labyrinth it is cleared less slowly than the alcohol in the blood. So you'll have alcoholic lymph, which is less dense normal lymph. Amazingly the whole process will make you feel like you're spinning in one direction then gradually in the opposite direction.
 
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