ah HAAAAAAAAAAA!

[xtcgrrrl]

I just had a brainstorm! For the past 6 months, I have been using my prescription of gabapentin (Neurontin) to get high, by saving it up and then using more than prescribed for one fun day. In between I take very little or none. Then my back started to hurt really bad (I have a slipped disc, and for a while it wasn't hurting so much, but now it's REALLY painful, so I started going back to the doctor) so I got prescribed Tramadol. After I started taking the Tramadol, the gabapentin didn't work so well. I was confused but I didn't really have time to fret about it because I wasn't concerned with getting high anymore, I was running around to doctors getting MRIs and trying to stay off my back and going to physical therapy and having lots of appointments at the spine clinic etc etc. In essence I was busy trying to GET WELL, and pain relief was more important than fun. But I was just browsing on BL tonight and something someone said in a thread somewhere (I lost the page and I'll never find it again but oh well) made me think: could the TRAMADOL be what's causing my Neurontin problem? As in, not being able to get high from it anymore? I remember that the person in the other thread said that Neurontin felt like Ultram to them in terms of the high which is what made me think of it...now if there are any people out there who have a background in science can you please explain to me why (or why not) this might be true?

 

[.:Holy::Toast:.]

From the Wikipedia page for gabapentin, besides working on GABA receptors it gains some of its mechanism of action by acting on NMDA sites

"One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus. This is mediated through its binding to presynaptic NMDA receptors"

Tramadol as well is an NMDA antagonist so it could prevent binding of gabapentin to the NMDA receptors, so this may be the cause of your problem.
But I'm not a pharmacologist so I don't really know

 

[BadassMoFo]

From the Wikipedia page for gabapentin, besides working on GABA receptors it gains some of its mechanism of action by acting on NMDA sites

"One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus. This is mediated through its binding to presynaptic NMDA receptors"

Tramadol as well is an NMDA antagonist so it could prevent binding of gabapentin to the NMDA receptors, so this may be the cause of your problem.
But I'm not a pharmacologist so I don't really know

I was thinking the same thing. They both deal with similar parts of the brain so one may be negating the effects of the other.

 

[tentram]

(I lost the page and I'll never find it again but oh well)

look through your internet history?

tramadol should not interfere with the efficacy of the neurontin; its likely those one day binges which have boosted your tolerance considerably, rendering it almost useless unless in absurdly high doses.

 

[xtcgrrrl]

look through your internet history?

tramadol should not interfere with the efficacy of the neurontin; its likely those one day binges which have boosted your tolerance considerably, rendering it almost useless unless in absurdly high doses.

Finding the PAGE is not the issue. Finding the exact sentence or post that made me think of it in a full page of posts is why I'll never find it...too lazy...oh well!

Would my tolerance go down if I stopped taking it for a really long time?

 

[.:Holy::Toast:.]

Yes that is generally how tolerance works

 

[benzoman12345]

Once you have a tolerance to Tramadol or any Opiods/Opiates from getting high you're fucked for using them for pain, you need to not use them for about a month and let your system forget what they are