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Agonist + antagonist in new formulations of pain meds

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Endprohibition

Greenlighter
Joined
Aug 24, 2015
Messages
17
I saw a post from way back in 08 suggesting that this may happen soon in the states. My PM advised me around that time that they were ending oxycodone and wanted me to take a long term med and consider switching to a different short term med. I was in the office when a rep from Purdue came in and was telling him that he had to write pain scripts differently. After that I noticed that my scripts would have Capitol letters in some parts or the drug name but not all. And only for the pain meds. Not the other scripts he gave me. When questioned he always changed the subject real fast. I was on a heavy dose of 6 30's a day and two 80's extended OC. It was after three back to back surgeries. I was in another world and decided to go cold turkey. That wasn't a option after a couple weeks, I started back on like a couple 15's a day. It worked up, then I would take myself down to 10's. Never had he told me he had to do such. It was always my own doing. After him telling me this about the oxy's ending and me seeing the script change, I noticed that they didn't do anything but put me to a place I have only heard discribed by meth users. Couldn't sleep, amped, with lil to no pain control. I have been seeing this same dr for about 10 years. During that time I have noticed several things that just are not right. Would take forever to explain. I always wondered if it had something to do with the long term meds. I have tried them all. Recently with the fentanyl patch for the second time. It would burn my skin like a chem burn and I would go thru what I suggest was severe withdraws. When mention this he would say impossible. I am now back on 60's of MS Contin along with 140 this month but had been 180 of k8's. Always when switching I can feel a lil something for a couple maybe three days. I can take 6 - 8 even 10 30's of oxy or Dillys and feel nothing. My thought was that he was correct and that they were adding naloxone or something similar to one or both meds. I wondered why I haven't seen any recent post since about the time of the change. Wondered if they were being sensored in some fashion. Anyway, after much digging I found some info that I can only say from a non pro standpoint, that I was correct. I have no other explanation as to why the sudden change and everything else I had seen and heard. I am going to confront him hopefully this am. If not by my next appt. i also was on 6 30's and 2 80's a day recently after I had that convo. They were not working well and I would feel nothing. I had found a old 15 from who knows when in my truck. I took it, and wow, it hit hard. Hard as blowing a old 30. Anyone here that could explain this or help in any way??? I can go more into detail if need be but this seems way too long already. Thanks in advance.
 
Damn newbies. I just noticed I posted this in the wrong area. Please move to correct area or let me know where it should move to and the best way to do so. Thanks again.
 
I'm on the oxy 20s ir and I don't see any difference IMO. I know they fucked around with the er formula and a lot of people can't metabolize them correctly so they don't work for some people. I have no explanation as to why ur not feeling your k8s though, that's strange...
Eventually they will make everything tamper proof probably but they will always need ir meds so idk. Hope this helps a little anyways.
 
I'm now on 60 er MS Contin and 5 k8's. As I say, I can take a handful and feel nothing. After doing some research I have found that in Ausi they have been doing this and my only outcome is that my pm being a anyisteoligist that I know formulates meds is doing something as such. I have found quite a few things suggeting that this is not rare. Was wanting to know if anyone else has had this problem.
 
I have read that naloxone and such things binds to your receptors like a key broke off in a lock. My only explanation to what I am dealing with.
 
Well no one will feel the morphine orally, lol. I can't explain the k8s though. Maybe someone else is having a similiar problem. I thought at one time that my pills were bunk too but when anyone else took a pill of mine they got zootes I just chalked it up to my tolerance and being on the same dosage for 7yrs...
 
Last month after having such a terrible time with the patch, he said I was experiencing hypoallegisia? I know what that is. Just know I spelled it wrong. I told him it was the patch. After the switch I had none of the issues I was having and had pain relief. As I said b4, for a couple days I could even feel I took something. Then it tapers. When doing a search for agonist + antagonist in extended release, low and behold, pics appear. With the m boxed 60 MS Contin that my pharm that is a hospital supplies. I have to go there do to my wife working there and insurance. All meds have been free since this change by the way. Which also makes me wonder in a huge way. They will only give three options for long term meds. OP's this Morhine sulphate and the patch. All of which has put me in the hospital for different reason. Migraines, stomach issues and with the patch, severe withdraws. I'm at my witts end and ready to go to H. Something at 46 that I have avoided thanks to my real father showing me what it's like on his end. Have always promised myself I would never or do needles. Although I am starting to thing that any RO is a RO, I do know that shooting can get very ugly and a road I don't want to start. Although living in bed or the bath, is no life at all. My mother took her life for this same reason and deff why I have not done so myself. I couldn't put my kids thru that again. I am thinking maybe of stopping PM and going to a methadone clinic and doing H by other routes then needles at this point. And I know I don't want that. But again, this is no way to live for 5 years or so. Thanks again for the help.
 
Dr wanted to switch me back to oxy's last month before taking away 40 but writing for a 28 day supply. If I knew they worked like back in the day or like the 15 I had found, I would t need 6 a day or the long term med at all. I know that they will just be like the ones I had before that I had the meth like feeling from. Never doing meth myself either, again, just what I have heard it was like. I have read that they have been adding naloxone to oxy as well. Can't find anything deff to say that they are in the states, but my experiences above plus others tells me that this is the case. I did enjoy the Buzz, but way more important was the pain releif. Would give the buzz part up in a min if I could get the same pain relief. I see people saying that your haut associating the buzz feeling with pain relief. Which leads me to believe again that this is true and that those kind of posts are not from someone I would take advice from. I think probably someone like a pharmacy rep ect.
 
If it were tolerance, then double, triple, 4x's the dose would take care of that. Another thing is that my PM says that they will only send records to certain drs. And I can't see them myself. They really screwed things up here in FL years ago. It was bad, but now it's horrible in the opposite direction.
 
Fuck man in sorry ur in this predicament! I too was getting inadequate relief fromy Oxys so I did move on to heroin. Just sniffing if but it is a world of difference for me. Round the clock relief but sometimes u get some garbage and that really sucks along with the inevitable legal issues. I'm not recommending this course of action by any means I just wanted u to know that I totally understand where ur coming from, I've been in the exact same mind space and have thought of the same solutions that u have. I gotta say that I'm spending way less money now that I'm not buying blues all the time. It's a double edges sword I guess. I just couldn't suffer anymore just because my dr is afraid of the dea like he says or whatever the real reasons are.
It's a damn shame that we have to even think about going this route because of the government. It really upsets me to no end. Wtf so they expect us to do, suffer? Well fuck that shit man we do what we gotta do to keep sane and somewhat active. We have to make a living right? I know I can't even think about going to work in intractable pain and I don't think I should have too.
 
Dammit man! Had this wrote and my browser closed. Sure I won't remember it all but here's a shot! Very sorry to hear that you or anyone has delt or has to deal with the same. And to hear that you did have to go that route. Not that I think bad of it, it's that the way society has put the stigma on it. If I knew somewhere to get some, I would have tried it long ago. My real father would be of help here but is far from local. He still shoots H as well as his Dillys that he uses in a week or less and has to go back to H. I see that or checking out as my only options soon if something don't change but been saying that for years now. Again, if I knew where to get some I would be there. Although I would have to scrap and hide cause I can't work and if the wife found out, I would be hungry, single and homeless fast. I am sure that I would work again and be able to enjoy life again if I could just get some kind of relief. Living in bed, or the tub is not a life. I was able to get a lil CO and that helped tremendously. At least with my frame of mind and being able to not complain. Nothing for major pain relief but again, I had a hard time even feeling that in huge doses which also lead me to believe that there's some sort of blocker. Dr gave me the synthetic stuff cause I went from 198 to 118 lbs in about 6 months. Dropping 50 lbs a months several times, then going up a lil only to wind up at 118. I had the CO at that time and what is what I contribute my gain to 145 presently to. Now that that's gone, I hate life again. I am only bringing my wife down and realize that every min of every day. She is a professional that is well looked up to. Even going out a couple few times a year ends up real bad and makes us both look very bad when I have to leave a few mins in to the eve. She gets so embarrassed as do I. So I stooped trying and let her do her thing. Thanks for the ear and help. I wish you the best my brother! (At least I think brother per your name).
 
Oh, one thing I just remembered that I wrote and forgot to write again when it closed on me. I know you shouldn't talk prices of meds ect, but is it ok to tell me in some sort of way, what I or you would be spending a day, week or month after switching. As I said, I can't and haven't been able to work in years. So money is a real thing. If it were to help, I would work again in a second. As I say feel like a man again. The only good part about these pills are that they are free through the hospital and insurance we have thru it. Thanks again.
 
Sry endpro I had to go to work and I just got home. I was spending about 2k a mth on blues now I'm spending 1k a month on h. Idk how to send a pm, if u could figure it out shoot me a message. I haven't been on bl in about a yr and I forgot how to do a bunch of shit here.
 
Thanks Cliffy, I was out cold. Catching up on much needed sleep. I will try to figure it out a lil later and send ya a message. I tried to send one last night and didn't see how when I clicked on someone's profile but stopped there. 1k is deff outta the question. No return call from the pm again. Life's not good. Hope it's better there. Have a good one my friend.
 
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